PKB/Akt
Activated Notch1 Inhibits p53-Induced Apoptosis and Sustains Transformation by Human Papillomavirus Type 16 E6 and E7 Oncogenes through a PI3K-PKB/Akt-Dependent Pathway
... by PKB/Akt leads to nuclear ...phosphorylated PKB/Akt, possibly due to low levels of phos- phorylated PKB/Akt in these ...
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Original Article Periostin inhibits hypoxia-induced apoptosisin human periodontal ligament fibroblasts via the Akt/PKB signaling pathway
... and Akt/ PKB inhibitor decreased pAkt Ser473 level; while Akt/PKB inhibitor overturned the positive effect of periostin on pAkt Ser473 expression under hypoxic ...of Akt/PKB ...
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Different effects of the inhibition of Src activity on Akt/PKB in melanoma cells with wild BRAF and mutated BRAF V600E
... of Akt/PKB at Ser473 and Thr308 in SK-MEL-5 cells that were treated with rapamycin or ...of Akt/PKB at Ser473 and Thr308 was examined using the specific anti-phospho Ser473-Akt antibody ...
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Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes
... with Akt/PKB at its pleckstrin homology domain, prevent- ing interaction with phosphatidylinositol 3,4,5-trisphosphate, and therefore reducing Akt/PKB membrane translocation and ...
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Role of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in AKT/PKB-Mediated Inhibition of Hepatitis B Virus Biosynthesis
... Hepatitis B virus (HBV) transcription and replication are essentially restricted to hepatocytes because liver-enriched transcription factors govern viral RNA synthesis. The level of transcription from the HBV promoters ...
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Acute modulation of endothelial Akt/PKB activity alters nitric oxide–dependent vasomotor activity in vivo
... kinase Akt, also referred to as protein kinase B (PKB), is a multifunctional regula- tor of glycogen synthesis, growth, and survival at a cellu- lar level ...of Akt occurs through the binding of the ...
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Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation
... Colorectal cancer (CRC) is the second most common cause of cancer-related death, encouraging the search for novel therapeutic targets affecting tumor cell proliferation and migration. These cellular processes are under ...
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Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models
... Until recently, the only available loss-of-function model for IGF1 and IGF1 receptor was a dominant-negative, kinase-inactive form of the b-subunit of IGF1 receptor driven by a muscle-specific promoter (MKR mice) [59]. ...
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Hepatitis C virus E2 protein involve in insulin resistance through an impairment of Akt/PKB and GSK3β signaling in hepatocytes
... and Akt phos- phorylation that lead to insulin resistance ...of Akt at Ser473 appears to precede phosphorylation by PDK1 at Thr308, both sites are separated by 165 amino acids ...of Akt has been ...
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High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury
... baseline PKB/Akt (evaluation of activation during reper- fusion was not ...basal PKB/Akt and GSK- 3β ...and PKB/ Akt were similar in the three groups studied [Lochner A, Genade ...
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Investigating roles for the deubiquitylating enzymes in the PtdIns3-K/PKB pathway in cancer
... The project employed a DUB siRNA library to perform a series of RNAi screens using two complementary approaches. In the first approach, the effects of DUB depletion on the protein level of nine PtdIns3-K pathway ...
255
Akt1/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization
... of Akt may be necessary to main- tain the viability of polyploid ...promoted Akt-dependent VSMC polyploidiza- ...of Akt signaling, fail to induce VSMC polyploidization may be related to the ability ...
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The role of death-associated protein 3 in apoptosis, anoikis and human cancer
... characterised the activation of caspase 8 to be a late event in anoikis, which was not likely to be the initiator of the cascade [86]. However, more recent studies in lymphocytes, oesophageal squamous cell and breast ...
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PDGF-BB regulates the pulmonary vascular tone: impact of prostaglandins, calcium, MAPK- and PI3K/AKT/mTOR signalling and actin polymerisation in pulmonary veins of guinea pigs
... The PI3K/AKT/mTOR pathway highly contributes to mediate the proliferative aspects of PDGFR [3, 101]. Here both, PI3K-α which is expressed ubiquitously [106] and PI3K-γ which is expressed in the cardiovascular sys- ...
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Clarification of the molecular pathway of Taiwan local pomegranate fruit juice underlying the inhibition of urinary bladder urothelial carcinoma cell by proteomics strategy
... 2; Akt/PKB: protein kinase B; BAG2: BCL2-associated athanogene 2; BCL 10: B-cell lymphoma/leukemia 10; CAPZA1: F-actin-capping protein subunit alpha-1; CFL1: C ofilin; DUT: dUTP pyrophosphatase; eIF5A: ...
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Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca2+]i,ICa, and Ca2+ transients in HL-1 cardiomyocytes
... These findings also have implications for our under- standing of the role of PI3K/Akt-PKB signaling in dis- ease. As noted above, we have reported that sepsis results in decreased activation of the ...
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Flavonoids in modulation of cell survival signalling pathways
... in the pathogenesis of various diseases (Williams et al. 2004). Evidences are mounting to show that flavonoids and their metabolites may exert modulatory actions in cells through actions on protein kinase and lipid ...
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GLUT CLASSIFICATION (SLC2A, SLC5A)
... The entry of glucose across the cell membrane may be insulin dependent, as the case of the membrane translocate of GLUT4 by Akt activation PKB in the signaling pathway of the A Monthly D[r] ...
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Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism
... sequence contexts, and reflect the independent operation of several different protein kinases (40, 42, 44 – 49, 57). The initial modification involves the multiple phosphorylation of a cluster of (Ser/Thr) Pro sites, ...
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Akt Inhibitor Akt-IV Blocks Virus Replication through an Akt-Independent Mechanism
... in Akt phosphorylation following the addition of Akt-IV was unexpected based on data in previous reports (19) and led us to question whether Akt-IV’s stimulation of Akt Thr308 and Akt ...
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