PLA2, phospholipase A2
Computational investigations of physicochemical, pharmacokinetic, toxicological properties and molecular docking of betulinic acid, a constituent of Corypha taliera (Roxb ) with Phospholipase A2 (PLA2)
... Phospholipase A2 (PLA2) hydrolyzes the membrane glycerophospholipids and releases arachidonic acid even- tually leading to the production of pro-inflammatory mediators such as leukotrienes, ...
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In silico and in vitro study of the bromelain-phytochemical complex inhibition of phospholipase A2 (Pla2)
... Abstract: Phospholipase A2 (Pla2) is an enzyme that induces inflammation, making Pla2 activity an effective approach to reduce ...this Pla2 inhibitory activity has important therapeutic ...
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Venom proteomics and antivenom neutralization for the Chinese eastern Russell’s viper, Daboia siamensis from Guangxi and Taiwan
... siamensis of Taiwan island; KSPI, Kunitz-type serine protease inhibitor; PLA2, phospholipase A2; Snaclec, snake venom C-type lectin/lectin-like protein; SVSP, snake venom serine protease[r] ...
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Influence of obesity and cardiometabolic makers on lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in adolescents: the healthy young cross-sectional study
... Anti-LDL( − ): Autoantibodies against electronegative low density lipoprotein; Apo AI: Apolipoprotein AI; Apo B: Apolipoprotein B; BMI: Body mass index; HDL: High density lipoprotein; HO[r] ...
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Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, platelet-activating factor acetylhydrolase (PAF-AH) in leukocytes and body composition in healthy adults
... In multiple regression models upper and total adiposity measures were positively associated with Lp-PLA 2 activity in men after adjusting for LDL-cholesterol, age, smoking, hs-CRP and p[r] ...
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Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A2 (Lp-PLA2 ): a review
... Aschermann M, Duckers H, Bleie O, Dudek D, Bøtker HE, von Birgelen C, D ’ Amico D, Hutchinson T, Zambanini A, Mastik F, van Es GA, van der Steen AF, Vince DG, Ganz P, Hamm CW, Wijns W, Zalewski A, Integrated Biomarker ...
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Antibacterial properties of chicken intestinal phospholipase A2
... IIA PLA2 is one of the key enzymes in the process of inflammation that regulates the synthesis of arachidonic acid and lyso- phospholipids ...IIA PLA2 is unusual because of the highly cationic nature of the ...
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Interferon gamma induces the synthesis and activation of cytosolic phospholipase A2
... of phospholipase A2 (PLA2) in BALB/c 3T3 fibroblasts and a human neuroblastoma cell ...cytosolic phospholipase A2 (cPLA2) in a human bronchial epithelial cell line (BEAS ...the ...
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In vitro study of the PLA2 inhibition and antioxidant activities of Aloe vera leaf skin extracts
... IIA phospholipase A2 (hG-IIA) and Me-Indoxam were generous gifts from ...IB phospholipase A2 (pG-IB), Egg yolk phosphatidylcholine or lecithin, red phenol and sodium taurodeoxycholate (NaTDC), ...
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Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis
... stress. For example, it is under these conditions that sPLA2 may exert the most profound effects on the activity of cytosolic PLA2 (cPLA2 [32]). The specific involvement of cPLA2 in EAE has also been demonstrated ...
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Subcellular characteristics of phospholipase A2 activity in the rat kidney Enhanced cytosolic, mitochondrial, and microsomal phospholipase A2 enzymatic activity after renal ischemia and reperfusion
... of PLA2 activity, but ischemia and reperfusion resulted in the appearance of a new peak of activity in cytosolic and mitochondrial fractions (Mr approximately 2-3 ...of PLA2 activity, likely representing ...
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Glucocorticoid deficiency increases phospholipase A2 activity in rats
... of PLA2 mRNA, protein, and enzyme activity in adrenalectomized (ADX) rats where glucocorticoid concentrations were below physiological ...II PLA2 were measured by PCR. Group II PLA2 mRNA was ...
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Study of the Activity of Phospholipase A2 in Venom of the Transcaucasian Macrovipera Lebetina Obtusa
... the PLA2 and myotoxins) are neutralized by various compounds, such as antibodies and proteins purified from animal ...have PLA2 inhibitory proteins, called PLIs, in their blood ...against PLA2 ...
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Predicting the mechanism of phospholipidosis
... pase A2 (LYPLA2) has previously been linked with phospholipidosis, however, due to the lack of data in ChEMBL it was not present in the ...and phospholipase A2 (PLA2) were present in the model ...
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Lipoprotein Associated Phospholipase A2 Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome
... Progression to ACS seems to depend most on exaggerated inflammatory changes within atherosclerotic plaques.1-3 In recent studies, lipoprotein-associated phospholipase A2 Lp-PLA2 was foun[r] ...
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A snake venom phospholipase A2 blocks malaria parasite development in the mosquito midgut by inhibiting ookinete association with the midgut surface
... of PLA2, nor did the PLA2 have a significant effect on the total yield of macrogametes/zygotes obtained at the end of the purification (Table ...the PLA2 was added to purified zygotes, which were ...
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IN SILICO VALIDATION OF ANTI-RUSSELL’S VIPER VENOM ACTIVITY IN PHYLLANTHUS EMBLICA L. AND TAMARINDUS INDICA L.
... neutral phospholipase A2 RVV-PFIIc, L-amino acid oxidase, Russell's viper venom serine proteinase, RVV-V, cytotoxin drCT-1, dabocetin alpha subunit and cysteine-rich secretory protein Dr-CRPK using the tool ...
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Phospholipase A2 is involved in galactosylsphingosine induced astrocyte toxicity, neuronal damage and demyelination
... that PLA2 inhibitors rescue the decrease of human astrocyte cell viability induced by psychosine ...of PLA2 (cPLA2), rather than the secretory form (sPLA2), is involved in psy- chosine-induced toxicity in ...
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Unusual stability of messenger RNA in snake venom reveals gene expression dynamics of venom replenishment.
... PCR amplification of a range of venom protein transcripts including snake venom metalloproteinases (SVMP), phospholipase A2 (PLA2), serine protease (SP), C-type lectins (CTL), vascular e[r] ...
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Anti-inflammatory and antioxidant activity of salicylic acid conjugated dihydropyrazoline analogues
... by phospholipase A2 (PLA2) inhibition and in vitro antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl, nitric oxide, hydroxyl radical scavenging assay and ferrous ion chelating assay wherein ...
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