plasminogen activator inhibitor type-1
Interaction between plasminogen activator inhibitor type 1 (PAI 1) bound to fibrin and either tissue type plasminogen activator (t PA) or urokinase type plasminogen activator (u PA) Binding of t PA/PAI 1 complexes to fibrin mediated by both the finger and the kringle 2 domain of t PA
... urokinase-type plasminogen activator ...by plasminogen activator inhibitor type 1 (PAI-1) that is either present in plasma or bound to fibrin, present in a ...
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Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity
... for plasminogen activator inhibitor type 1 Indirect ELISA was used for the recombinant mouse PAI-1 protein ...(diluted 1:1 in 50 mmol/l carbonate buffer, pH ...
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Expression of plasminogen activator inhibitor type 1 by human prostate carcinoma cells inhibits primary tumor growth, tumor associated angiogenesis, and metastasis to lung and liver in an athymic mouse model
... carcinoma further defines the role of the uPA/PAI-1/plasmin system in primary growth and metastasis. A marked increase in PAI-1 expression was induced in clones of the aggressive human prostate carcinoma ...
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Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin
... in plasminogen-defi- cient mice (2), in mice overexpressing PAI-1 (47), and in sev- eral models of tumor metastasis (43, 48, 49) are recent verifica- tions of this long-held ...
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Behçet’s disease: new insight into the relationship between procoagulant state, endothelial activation/damage and disease activity
... minogen activator (t-PA) (TriniLIZE tPA antigen ELISA kit) and plasminogen activator inhibitor type 1 (PAI-1) (TriniLIZE PAI-1 antigen ELISA kit); all kits were ac- ...
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Association of dietary soy with expression of various pro-inflammatory genes in porcine phagocytes
... urokinase-plasminogen activator (u-PA), u-PA receptor (u- PAR), plasminogen activator inhibitor type 1 and 2 (PAI-1, PAI-2), intercellular adhesion molecule ...
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Angiotensin II regulates the expression of plasminogen activator inhibitor 1 in cultured endothelial cells A potential link between the renin angiotensin system and thrombosis
... fibrinolysis, serving as the primary inhibitor of tissue-type plasminogen activator. Elevated levels of PAI-1 are a risk factor for recurrent myocardial infarction, and locally ...
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Targeted expression of plasminogen activator inhibitor(PAI)-1 to the stomach inhibits gut-brain signalling by the satiety hormone cholecystokinin (CCK)
... second type aims to increase physical activity and lipid oxidation via catecholaminergic systems within the CNS and ...final type aims to reduce the absorption of lipids from the diet via lipase inhibition ...
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High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA Study
... predict type 2 diabetes in long-time follow up of population samples, although adjusting for measurements of obesity attenu- ates the relationship ...of plasminogen activator ...
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Recombinant plasminogen activator inhibitor 1 reverses the bleeding tendency associated with the combined administration of tissue type plasminogen activator and aspirin in rabbits
... The major side effect of thrombolytic therapy is bleeding; however, the pathogenesis of this potential complication is not well understood. Accordingly, we examined the effects of aspirin and recombinant human ...
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Bleeding diathesis due to decreased functional activity of type 1 plasminogen activator inhibitor
... Serum plasminogen (40%, normal 72-128%) and alpha 2-antiplasmin (55%, normal 70-145%) activities were ...tissue-plasminogen activator (t-PA) levels in serum were normal ...fibrinolytic ...
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Association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects
... Plasminogen activator inhibitor-1 (PAI-1) is the pri- mary physiological inhibitor of endogenous fibrinolysis that acts via inhibition of the tissue plasminogen activa- ...
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Effects of pitavastatin on plasminogen activator inhibitor-1 in hyperlipidemic patients
... had type 2 diabetes (Table 1); of these 36, eleven were under treatment with sulfonylureas, 10 with α -glucosidase inhibitors, and seven with insulin ...
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Plasminogen activator inhibitor-1 and cardiovascular risk
... The aim of this study was to test the above observations in vivo, using AMI as the acute phase stimulant. The hypothesis tested in vivo, was that subjects homozygous for the 4G allele have an exaggerated response to ...
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Tissue-Type Plasminogen Activator, Plasminogen Activator Inhibitor, and Histidine-Rich Glycoproteins in Stressed Human Newborns
... Tissue-type plasminogen activator antigen was determined by an enzyme-linked immuno- sorbent assay (ELISA) method using a commercial kit (Imubind-5- tPA, American Diagnostica).4’9 Plasmi[r] ...
6
Regulation of urokinase plasminogen activator and plasminogen activator inhibitor-1 in murine breast cancer cells
... More than a century ago, Armand Trousseau first described an association between cancer and the coagulation system 1,2 . Later it was discovered that tumor cells release procoagulant microvesicles (often referred to as ...
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Index Catalog // Carolina Digital Repository
... wild type MDA- MB-231 and pLKO cells, the PAI-1 knockdown cells exhibited no decrease in Ki67 staining (Figure ...wild type MDA-MB-231 cells and pLKO cells (8% and 9%, respectively) (Figure ...
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Detection and partial characterization of an inhibitor of plasminogen activator in human platelets
... dependent manner. In both cases, the amount of inhibition increased when the releasates were preincubated with the purified activators, indicating a direct interaction between the activators and an inhibitor(s). ...
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Thrombin induction of plasminogen activator inhibitor in cultured human endothelial cells
... of plasminogen activator (PA) and plasminogen activator-inhibitor (PA-I) in medium conditioned by primary cultures of human umbilical vein endothelial ...
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A study on factors influencing the Outcome of Thrombolysis in Acute Myocardial Infarction
... This single chain glycoprotein directly inhibits plasmin. It is synthesised and secreted from hepatocytes. It is also stored in platelet α granules. Alpha 2 plasmin inhibitor rapidly neutralizes free plasmin in ...
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