Platelet-activating factor
Platelet activating factor: mediator of the third pathway of platelet aggregation? A study in three patients with deficient platelet activating factor synthesis
... Thrombin, collagen, and Ca2+-ionophore A23187 aggregate platelets in the presence of inhibitors of the first (ADP-mediated) and second (cyclooxygenase-dependent) pathway of platelet activation. This aggregation, ...
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Platelet activating factor mediates acid induced lung injury in genetically engineered mice
... Platelet-activating factor (PAF) is a proinflammatory phospholipid mediator that has various biologic effects, including cell adhesion, endothelial cell activa- tion, and the production of cytokines ...
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Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat
... of platelet activating factor to the same degree as the specific platelet activating factor antagonist WEB 2086 but has no influence on treacheal secretion elicited by ...of ...
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Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells
... Platelet-activating factor (PAF), prostaglandins (PGs), and lysophosphatidic acid (LPA) are the three major phospho- lipid mediators implicated in many different biological pathways in inflammatory ...
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Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage
... using platelet-activating factor (PAF) antagonists have indicated that PAF is involved in neuronal loss fol- lowing human immunodeficiency virus infection [7], in kainic acid-induced epilepsy models ...
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Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin.
... 4628-4635 Copyright X 1994, American Society for Microbiology Platelet-Activating Factor: a Candidate Human Immunodeficiency Virus Type 1-Induced Neurotoxin Received 8 February 1994/Acce[r] ...
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Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet activating factor
... that platelet-activating factor, an inflammatory phospholipid that mediates synaptic plasticity and neurotoxicity and is dramatically elevated in the brain during HAD, promotes dendrite injury ...
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Absence of platelet activating factor receptor protects mice from osteoporosis following ovariectomy
... While platelet-activating factor (PAF) is produced in various diseases associated with bone resorption, its functions in bone metabolism remain ...autocrine factor for osteoclast ...
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Vitamin C blocks inflammatory platelet activating factor mimetics created by cigarette smoking
... by platelet-activating factor (PAF) receptor antagonists, and correlates with the accumulation of PAF-like mediators in the blood of cigarette smoke–exposed ...
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Altered Platelet Activating Factor Metabolism in Insulin Dependent Diabetes Mellitus
... majorcontributing factor in this process is the hyper-reactivity of platelets which can lead to increased platelet adhesion and aggregation 6 .... Platelet activating factor (PAF) is a ...
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Role of platelet activating factor in Chinese hamster ovary cell responses to cholera toxin
... secretion and CHO elongation by platelet-activating factor (PAF) receptor antagonists and secretion of PAF by human intestinal epithelial cells exposed to CT. Herein, we show that PAF is involved ...
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Platelet activating factor mediates hemodynamic changes and lung injury in endotoxin treated rats
... Within 20 min after intraperitoneal injection of Salmonella enteritidis endotoxin in rats, blood platelet-activating factor (PAF) increased from 4.3 +/- 1.3 to 13.7 +/- 2.0 ng/ml (P less than 0.01) ...
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Interleukin 1 stimulates platelet activating factor production in cultured human endothelial cells
... Monocyte-derived interleukin 1 (IL-1) was found to be a potent inducer of platelet-activating factor (PAF) in cultured human vascular endothelial cells (HEC). The product was identified as PAF by its ...
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Exploring the plasmatic platelet-activating factor acetylhydrolase activity in patients with anti-phospholipid antibodies
... Platelet-activating factor acetylhydrolase (PAF-AH) is a family of enzymes, the most abundant of which is the plasma form, also called lipoprotein-associated phospho- lipase A2 (Lp-PLA2) ...important ...
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Synergistic effects of combined platelet-activating factor receptor and epidermal growth factor receptor targeting in ovarian cancer cells
... growth factor (EGF) and transforming growth factor (TGF) can activate ...that platelet- activating factor (PAF) also induced increased EGFR phosphorylation ...
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In vitro anti-inflammatory and anti-coagulant effects of antibiotics towards Platelet Activating Factor and thrombin
... inflammation Platelet Activating Factor (PAF) and the coagulant factor thrombin are ...rabbit Platelet Reach Plasma (rPRP) by evaluating their IC 50 ...
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Platelet-Activating Factor Antagonists Decrease Follicular Dendritic-Cell Stimulation of Human B Lymphocytes
... for platelet activating ...human platelet-activating factor receptor mRNA in human B lymphocytes by polymerase chain reac- tion on reverse transcripts (RT-PCR) [published erratum ...
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Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP
... Stimulation of human neutrophils with chemoattractants FMLP or platelet activating factor (PAF) results in different but overlapping functional responses. We questioned whether these differences ...
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Platelet activating factor mediates interleukin 2 induced lung injury in the rat
... Interleukin-2 was recently shown to cause acute lung injury characterized by microvascular permeability defect, interstitial edema, and leukosequestration. Similar responses can also be produced by platelet ...
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Deficiency of platelet activating factor acetylhydrolase is a severity factor for asthma
... toms. Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl- sn-glycero-3-phosphocholine) has been implicated in the pathophysiology of inflammation in ...
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