Platelet derived growth factor:
Platelet derived growth factor in idiopathic pulmonary fibrosis
... several growth factors including platelet-derived growth factor ...tissues derived from five patients with idiopathic pulmonary fibrosis (IPF) and from four control individuals ...
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Chemotaxis of monocytes and neutrophils to platelet derived growth factor
... The platelet-derived growth factor (PDGF) is shown to be chemotactic for monocytes and ...epidermal growth factor shows no chemotactic activity for inflammatory cells at ...
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The role of platelet derived growth factor in the development of mouse molars
... Int J De, MiDI 39 939 945 (1995) 939 Original Arlie/I' The role of platelet derived growth factor in the development of mouse molars JAN CoCo HU", CHUHUA ZHANG' and HAROLD C SLAVKIN2 IDepartment of Pe[.] ...
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Origin of platelet derived growth factor in megakaryocytes in guinea pigs
... Growth factor activity, as determined by the stimulation of [3H]thymidine incorporation into the DNA of quiescent 3T3 cells in culture, was found in lysates of guinea pig platelets and ...significant ...
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Interactions of insulin, insulinlike growth factor II, and platelet derived growth factor in erythropoietic culture
... Furthermore, when added to cultures with electrophoretically pure platelet-derived growth factor, their respective activities were synergistic. We conclude that insulin and IGF-II potentiate ...
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Platelet isoforms of platelet derived growth factor stimulate fibroblasts to contract collagen matrices
... of growth factors that are thought to initiate and sustain the ...the platelet and monocyte isoforms of platelet-derived growth factor (PDGF; AB and BB) but not PDGF-AA, can ...
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Platelet derived growth factor activity and mRNA expression in healing vascular grafts in baboons Association in vivo of platelet derived growth factor mRNA and protein with cellular proliferation
... an antibody to human platelet-derived growth factor (PDGF). In addition, Northern analysis of total RNA demonstrated higher expression of PDGF-A chain mRNA in the graft intima compared t[r] ...
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Targeting platelet-derived growth factor as a therapeutic approach in pulmonary fibrosis
... Keywords : idiopathic pulmonary fibrosis, platelet-derived growth factor, tyrosine kinase, fibroblast Received for publication July 2, 2013 ; accepted August 26, 2013. Address correspondence ...
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Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB
... So far, a few human studies have been published investigating changes in circulating hepcidin levels during hypobaric hypoxia. 28–30 These studies provide interesting insights into hypoxia mediated changes of iron ...
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Clinical Significance of Platelet Derived Growth Factor C Expression in Colorectal Cancer
... ABSTRACT Platelet-derived growth factors (PDGFs) are known to be associated with tumor growth and angiogenesis through their activation of the receptor tyrosine kinases, PDGF receptors alpha ...
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Platelet derived growth factor promotes proliferation of erythropoietic progenitor cells in vitro
... to platelet-derived growth factor ...with platelet-poor plasma-derived serum (PDS) form fewer erythroid colonies than do cells cultured with human whole blood serum or fetal calf ...
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Platelet-derived growth factor-C functions as a growth factor in mouse embryonic stem cells and human fibrosarcoma cells
... 33. Ehnman M, Missiaglia E, Folestad E, Selfe J, Strell C, Thway K, Brodin B, Pietras K, Shipley J, Östman A, Eriksson U. Distinct effects of ligand-induced PDGFR α and PDGFR β signaling in the human rhabdomyosarcoma ...
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Structural analysis of platelet-derived growth factor receptor alpha by protein homology modeling
... v ABSTRACT Constitutive phosphorylation activity by receptor tyrosine kinases due to activating mutations have been linked to human malignancies. Substitution mutation of tyrosine 849 to serine residue led to the ...
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Role of platelet-derived growth factor receptor-α and -β in pulmonary fibrosis in mice
... Abstract Platelet-derived growth factor (PDGF) has been implicated in the pathogenesis of pulmo- nary ...the growth of lung fibroblasts were examined using the 3 H-thymidine ...
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Stimulation of granulation tissue formation by platelet derived growth factor in normal and diabetic rats
... J Clin Invest. 1985;76(6):2323-2329. https://doi.org/10.1172/JCI112243. Subcutaneous implantation of Hunt-Schilling wound chambers in rats induces a wound repair response causing the chamber first to fill with fluid and ...
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Platelet derived growth factor enhances in vitro erythropoiesis via stimulation of mesenchymal cells
... The growth of erythroid colonies (from erythroid colony-forming cells) and erythroid bursts (from burst-forming cells [BFU-E]) is enhanced in the presence of serum as compared with ...enhanced growth is due ...
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Platelet derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization
... https://doi.org/10.1172/JCI113671. Platelet-derived growth factor (PDGF) mRNA, and mRNA for its receptor, have been localized to specific cell types within the human atherosclerotic plaque, ...
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Effects of Alendronate on Human Alveolar Osteoblastic Cells: Interactions with Platelet- Derived Growth Factor
... Although chronic use of BPs has been associated with side effects such as atypical femoral fractures and osteonecrosis of the jaw, these drugs are still widely used because of their generally positive therapeutic effects ...
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Platelet-derived growth factor predicts prolonged relapse-free period in multiple sclerosis
... different growth fac- tors involved in neuronal and oligodendroglial cell sur- vival [7, ...the platelet-derived growth factor (PDGF) is recently emerging as a key molecule possibly ...
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<p>Vitreous and Serum Concentrations of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor in Proliferative Diabetic Retinopathy</p>
... Another growth factor found to contribute to the pathol- ogy of PDR is platelet-derived growth factor ...autocrine growth stimulator in the RPE cells, which participates ...
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