Platelet-Derived Growth Factor alpha Receptor
Molecular structure and transcriptional regulation of the gene for the platelet derived growth factor alpha receptor in cultured vascular smooth muscle cells
... PDGF has been shown to contribute to hypertrophy in vascular smooth muscle cells (VSMC). PDGF-AA differentially promotes protein synthesis in VSMC from spontaneously hypertensive rats (SHR) but not in those from ...
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Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial- mesenchymal transition
... Growth factor-reduced Matrigel (BD, Cambridge, MA), 130 μl was spread as a thick layer on 8-well chamber slides, and polymerized at 37 °C for 15 ...appropriate growth media containing with 2% ...
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Olaratumab: a platelet-derived growth factor receptor-α-blocking antibody for the treatment of soft tissue sarcoma
... the platelet-derived growth factor receptor-α (PDGFRα)-blocking antibody, olaratumab, dem- onstrated a significant difference in median overall survival in favor of the olaratumab ...
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Structural analysis of platelet-derived growth factor receptor alpha by protein homology modeling
... Corless, C. L., Schroeder, A., Griffith, D., Town, A., Mcgreevey, L., Harrell, P., Shiraga, S., Bainbridge, T., Morich, J. and Heinrich, M. C. (2005). PDGFRA Mutations in Gastrointestinal Stromal Tumors: Frequency, ...
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Immunolocalization of platelet‐derived growth factor receptor‐β (PDGFR‐β) and pericytes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
... Formalin-fixed paraffin-embedded post mortem brain tissue from the frontal lobe, Brodmann Area 9, was serially cut into 10-μm thickness sections and immunostained with various antibodies, including PDGFR- β antibody ...
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Inhibition of the platelet derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines
... receptors, alpha and beta, have been described [3,4]. The two receptor subtypes show different affinities for the dimeric PDGF ...PDGF-alpha receptor binds with high affinity all three forms ...
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Olaratumab in soft tissue sarcoma - Current status and future perspectives.
... against platelet-derived growth factor receptor-alpha (PDGFR a ), was combined with standard doxorubicin chemotherapy in anthracycline-naı¨ve advanced STS ...
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Type H blood vessels in bone modeling and remodeling
... its receptor on ECs to stimulate blood vessel ...secreted growth factors to promote osteoprogenitor survival and ...PDGF-BB, platelet-derived growth factor-type BB; SLIT3, slit ...
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Chrysotile asbestos upregulates gene expression and production of alpha receptors for platelet derived growth factor (PDGF AA) on rat lung fibroblasts
... PDGF-R alpha, blocked the PDGF binding sites that were upregulated by fiber ...PDGF-R alpha population on RLF without significant change in PDGF-R ...
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Regional expression of the platelet derived growth factor and its receptors in a primate graft model of vessel wall assembly
... PDGF receptor beta-subunit mRNA and protein were easily detectable in the neointima and graft ...PDGF receptor alpha-subunit mRNA was also observed in the graft matrix and at lower levels in the ...
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Inhibition of the platelet-derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines
... receptors, alpha and beta, have been described [3,4]. The two receptor subtypes show different affinities for the dimeric PDGF ...PDGF-alpha receptor binds with high affinity all three forms ...
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Function and regulation of Platelet-Derived Growth Factor Receptor Alpha during development
... Active PDGF is composed of dimers of A and B chains. All three dimeric isoforms of PDGF (AA, AB, BB) can bind to and activate PDGFRa in vitro. It is generally thought that, of these, PDGF-AA is the major ligand for PD G ...
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The Bovine Papillomavirus E5 Protein Requires a Juxtamembrane Negative Charge for Activation of the Platelet-Derived Growth Factor β Receptor and Transformation of C127 Cells
... endogenous platelet-derived growth factor (PDGF) b receptor through transmembrane and juxtamembrane interactions, leading to sustained receptor ...b receptor and indicated ...
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Evaluation of effectiveness of concentrated growth factor on osseointegration
... 32. Aghaloo TL, Moy PK, Freymiller EG. Investigation of platelet-rich plasma in rabbit cranial defects: a pilot study. J Oral Maxillofac Surg. 2002;60(10):1176 – 81. 33. Choukroun J, Diss A, Simonpieri A, Girard ...
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Effect of tyrosine kinase inhibitors, imatinib and nilotinib, in murine lipopolysaccharide induced acute lung injury during neutropenia recovery
... Methods: Mice were rendered neutropenic with cyclophosphamide prior to the intratracheal instillation of LPS. Imatinib or nilotinib was administrated by oral gavage during neutropenia recovery. In order to study the ...
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Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRβ Aptamer
... chemokine receptor type 4 (CXCR4) ...transforming growth factor β (TGF-β) and interleukin 17B [13]; CXCL10 and placental growth factor ...that platelet-derived ...
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Growth factor levels in leukocyte-poor platelet-rich plasma and correlations with donor age, gender, and platelets in the Japanese population
... in platelet α-granules and GFs and glycoproteins (adhesion factors) contained in the plasma, while maintaining an equilibrium in vivo (Alsousou et ...and platelet counts in ...and platelet counts in ...
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Rationale for targeting VEGF, FGF, and PDGF for the treatment of NSCLC
... giogenic therapy currently approved for NSCLC, there are several other compounds currently in clinical development, including monoclonal antibodies to VEGF and inhibitors of the intracellular tyrosine kinase domain of ...
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B cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle like cells in the skin
... noteworthy since PDGF and transforming growth factor beta are considered master regulators of the fibrotic process. An animal model with mutations in PDGFR a leading to excessive kinase activity was created ...
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Neovascular age-related macular degeneration: intraocular inflammatory cytokines in the poor responder to ranibizumab treatment
... Patients and methods: This is an observational, prospective study. Thirty-two eyes from 30 patients were included in the study: 11 patients who responded poorly to ranibizumab and were switched to aflibercept (AF group), ...
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