Platelet-derived growth factor receptor
Immunolocalization of platelet‐derived growth factor receptor‐β (PDGFR‐β) and pericytes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
... the platelet-derived growth factor receptor- β (PDGFR- β ) (for pericytes) and microvascular markers in the frontal cortex and white ...
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Tyrphostin AG1296, a platelet-derived growth factor receptor inhibitor, induces apoptosis, and reduces viability and migration of PLX4032-resistant melanoma cells
... melanoma growth and ...of receptor tyrosine kinases, including the platelet-derived growth factor receptor (PDGFR), has been identified to be the underlying mechanism for ...
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Olaratumab: a platelet-derived growth factor receptor-α-blocking antibody for the treatment of soft tissue sarcoma
... the platelet-derived growth factor receptor-α (PDGFRα)-blocking antibody, olaratumab, dem- onstrated a significant difference in median overall survival in favor of the olaratumab ...
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Inhibition of the platelet-derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines
... Malignant pleural mesothelioma (MPM) is a cancer of the pleural cavity resistant to chemotherapy. The identification of novel therapeutic targets is needed to improve its poor prognosis. Following a review of literature ...
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Inhibition of the platelet derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines
... Malignant pleural mesothelioma (MPM) is a cancer of the pleural cavity resistant to chemotherapy. The identification of novel therapeutic targets is needed to improve its poor prognosis. Following a review of literature ...
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Function and regulation of Platelet-Derived Growth Factor Receptor Alpha during development
... Active PDGF is composed of dimers of A and B chains. All three dimeric isoforms of PDGF (AA, AB, BB) can bind to and activate PDGFRa in vitro. It is generally thought that, of these, PDGF-AA is the major ligand for PD G ...
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Structural analysis of platelet-derived growth factor receptor alpha by protein homology modeling
... Human receptor tyrosine kinases (RTKs) and their ligands are important regulators of intracellular signal transduction pathways mediating various processes at cellular ...cell growth and migration (Lemmon ...
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CP-673451, a platelet-derived growth-factor receptor inhibitor, suppresses lung cancer cell proliferation and migration
... Here, we investigated the potential anticancer activi- ties of CP-673451, a PDGF-specific inhibitor, in NSCLC therapy. Our studies show that CP-673451 could efficiently suppress NSCLC cell viability, induce cell ...
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Medical approach to the treatment of feline injection site sarcoma with masitinib: a case report
... no clinical trials with masitinib have been published for feline patients. This compound has an interesting inhibitory profile to address FISS, selectively and potently inhibiting the tyrosine kinase receptors c-Kit, ...
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B cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle like cells in the skin
... fibrosis. Platelet-derived growth factor (PDGF) is a pivotal mediator of fibrosis; it has stimulatory effects on scleroderma fibroblasts by enhancing their proliferation and increasing ...
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Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRβ Aptamer
... chemokine receptor type 4 (CXCR4) ...transforming growth factor β (TGF-β) and interleukin 17B [13]; CXCL10 and placental growth factor ...that platelet-derived ...
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Genetic alteration and mutation profiling of circulating cell-free tumor DNA (cfDNA) for diagnosis and targeted therapy of gastrointestinal stromal tumors
... the growth of GISTs is critical for improving the efficacy of cancer therapy by match- ing targeted drugs to specific ...either platelet-derived growth factor receptor A (PDGFRA) ...
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Case Report Myxoid epithelioid gastrointestinal stromal tumor harboring an unreported PDGFRA mutation: report of a case and review of the literature
... of platelet-derived growth factor receptor α (PDGFRA) are detected in a significant proportion of gastrointestinal stromal tumors (GISTs), in addition to the more frequent mutation in ...
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Original Article The overexpression of PDGF-BB and its receptor is correlated with lymphatic metastasis in patients with non-small cell lung cancer
... prognostic factor for human ...multiple growth factors. Platelet-derived growth factor-BB (PDGF-BB) and platelet-derived growth factor ...
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PDGF/PDGFR effects in osteosarcoma and the “add-on” strategy
... The platelet-derived growth factor (PDGF)/platelet-derived growth factor receptor (PDGFR) pathway plays an important role in the development and metastasis ...
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Molecular mechanisms underlying therapeutic potential of pericytes
... 1): platelet-derived growth factor receptor β (PDGFRβ): re- ceptor with tyrosin kinase activity, involved in pericytes proliferation and recruitment [11]; nerve-glial antigen-2 (NG2): ...
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Effect of tyrosine kinase inhibitors, imatinib and nilotinib, in murine lipopolysaccharide induced acute lung injury during neutropenia recovery
... cell factor receptor; LPS: lipopolysaccharide; MPO: myeloperoxidase; PBS: phosphate- buffered saline; PCR: polymerase chain reaction;PDGF: platelet-derived growth factor; PDGFR: ...
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Reducing lung function decline in patients with idiopathic pulmonary fibrosis: potential of nintedanib
... kinase receptor antagonist which inhibits a number of key receptors, including those for platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF), ...
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Regional expression of the platelet derived growth factor and its receptors in a primate graft model of vessel wall assembly
... PDGF receptor beta-subunit mRNA and protein were easily detectable in the neointima and graft ...PDGF receptor alpha-subunit mRNA was also observed in the graft matrix and at lower levels in the ...and ...
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The Bovine Papillomavirus E5 Protein Requires a Juxtamembrane Negative Charge for Activation of the Platelet-Derived Growth Factor β Receptor and Transformation of C127 Cells
... b receptor interacted with glutamic acid 36 in the transformation-competent E5 mutants without a negative charge at position ...the receptor with only a modest change in the configuration of the E5 ...
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