Platelet-derived growth factor receptor alpha
Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial- mesenchymal transition
... Recently platelet derived growth factor receptor-alpha (PDGFRα) was recognized as a potential target to treat aggressive papillary thyroid cancer given its strong association ...
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Function and regulation of Platelet-Derived Growth Factor Receptor Alpha during development
... Active PDGF is composed of dimers of A and B chains. All three dimeric isoforms of PDGF (AA, AB, BB) can bind to and activate PDGFRa in vitro. It is generally thought that, of these, PDGF-AA is the major ligand for PD G ...
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Structural analysis of platelet-derived growth factor receptor alpha by protein homology modeling
... Elling, C., Erben, P., Walz, C., Frickenhaus, M., Schemionek, M., Stehling, M., Serve, H., Cross, N. C. P., Hochhaus, A., Hofmann, W.-K., Berdel, W. E., Müller-Tidow, C., Reiter, A. and Koschmieder, S. (2011). Novel ...
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Olaratumab: a platelet-derived growth factor receptor-α-blocking antibody for the treatment of soft tissue sarcoma
... the platelet-derived growth factor receptor-α (PDGFRα)-blocking antibody, olaratumab, dem- onstrated a significant difference in median overall survival in favor of the olaratumab ...
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Olaratumab in soft tissue sarcoma - Current status and future perspectives.
... against platelet-derived growth factor receptor-alpha (PDGFR a ), was combined with standard doxorubicin chemotherapy in anthracycline-naı¨ve advanced STS ...
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Molecular structure and transcriptional regulation of the gene for the platelet derived growth factor alpha receptor in cultured vascular smooth muscle cells
... PDGF has been shown to contribute to hypertrophy in vascular smooth muscle cells (VSMC). PDGF-AA differentially promotes protein synthesis in VSMC from spontaneously hypertensive rats (SHR) but not in those from ...
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Regional expression of the platelet derived growth factor and its receptors in a primate graft model of vessel wall assembly
... PDGF receptor beta-subunit mRNA and protein were easily detectable in the neointima and graft ...PDGF receptor alpha-subunit mRNA was also observed in the graft matrix and at lower levels in the ...
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Immunolocalization of platelet‐derived growth factor receptor‐β (PDGFR‐β) and pericytes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
... Formalin-fixed paraffin-embedded post mortem brain tissue from the frontal lobe, Brodmann Area 9, was serially cut into 10-μm thickness sections and immunostained with various antibodies, including PDGFR- β antibody ...
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Inhibition of the platelet-derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines
... receptors, alpha and beta, have been described [3,4]. The two receptor subtypes show different affinities for the dimeric PDGF ...PDGF-alpha receptor binds with high affinity all three forms ...
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Chrysotile asbestos upregulates gene expression and production of alpha receptors for platelet derived growth factor (PDGF AA) on rat lung fibroblasts
... PDGF receptor mRNA expression, PDGF binding, and mitogenic activity of PDGF ...PDGF- receptor alpha subtype (PDGF-R alpha) on RLF was upregulated after a 24-h exposure to asbestos in culture ...
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Platelet-rich plasma stimulates angiogenesis in mice which may promote hair growth
... The alpha granules of platelet began to secrete growth factors immediately once activated, and secreted almost all growth factors within an hour [18, ...
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Platelet derived growth factor inhibits bone regeneration induced by osteogenin, a bone morphogenetic protein, in rat craniotomy defects
... Platelet-derived growth factor (PDGF) is a potent moderator of soft tissue repair through induction of the inflammatory phase of repair and subsequent enhanced collagen ...
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Anti-VEGF agents in metastatic colorectal cancer (mCRC): are they all alike?
... important unanswered questions remain, including how to determine which patients and which tumors are the best candidates for these therapies; clearly, identifying antian- giogenesis biomarkers will be an essential ...
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Original Article The overexpression of PDGF-BB and its receptor is correlated with lymphatic metastasis in patients with non-small cell lung cancer
... Non-small cell lung cancer (NSCLC), one of the most common types of lung cancer among Chinese patients, is the leading cause of can- cer-related death, and only 15% of lung cancer patients live more than 5 years [1]. ...
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Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential
... bone-marrow derived MSCs contribute to tissue remodeling after injury ...EVs derived from ASCs that may represent a suitable source of adult stem cells for regenerative medi- ...angiogenic growth ...
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Excessive activation of the TLR9/TGF β1/PDGF B pathway in the peripheral blood of patients with systemic lupus erythematosus
... Results: Compared to healthy controls NControl = 56, levels of Toll-like receptor TLR9, transforming growth factor TGF-β1, and platelet-derived growth factor B PDGF-B were increased sign[r] ...
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Rationale for targeting VEGF, FGF, and PDGF for the treatment of NSCLC
... giogenic therapy currently approved for NSCLC, there are several other compounds currently in clinical development, including monoclonal antibodies to VEGF and inhibitors of the intracellular tyrosine kinase domain of ...
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Tyrphostin AG1296, a platelet-derived growth factor receptor inhibitor, induces apoptosis, and reduces viability and migration of PLX4032-resistant melanoma cells
... of tyrphostin AG1296, a PDGFR inhibitor, in melanoma, especially PLX4032-resistant melanoma both in vitro and in vivo. We found that tyrphostin AG1296 could effectively suppress viability of both PLX4032-sensitive and ...
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Growth factor levels in leukocyte-poor platelet-rich plasma and correlations with donor age, gender, and platelets in the Japanese population
... in platelet α-granules and GFs and glycoproteins (adhesion factors) contained in the plasma, while maintaining an equilibrium in vivo (Alsousou et ...and platelet counts in ...and platelet counts in ...
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Evaluation of effectiveness of concentrated growth factor on osseointegration
... many growth factors such as bone morphogenetic protein (BMP), platelet-derived growth factor (PDGF), insulin-like growth factor (IGF), vascular endothelial growth ...
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