Platelet-derived growth factor receptor B
Tyrphostin AG1296, a platelet-derived growth factor receptor inhibitor, induces apoptosis, and reduces viability and migration of PLX4032-resistant melanoma cells
... examined tyrphostin AG1296-induced apoptosis in A375R cells. Figure 2A and B shows that the fraction of cells with a subG1 DNA content increased significantly after treatment with tyrphostin AG1296 (P,0.01). We ...
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Tissue localization of beta receptors for platelet derived growth factor and platelet derived growth factor B chain during wound repair in humans
... epidermis and of the superficial dermis. In wounds, infiltrating mononuclear cells also stained for PDGF-AB/BB. To identify cell types expressing PDGF AB/BB and PDGF beta receptors, respectively, we performed double ...
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Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease
... Tyrosine receptor kinases and PKA activate the Src/Ras/ Raf/MEK/ERK ...cyst growth in nonorthologous models and Pkd1 heterozygous mice (127, 131), and a phase II clinical trial is currently ongoing ...
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Regional expression of the platelet derived growth factor and its receptors in a primate graft model of vessel wall assembly
... PDGF receptor beta-subunit mRNA and protein were easily detectable in the neointima and graft ...PDGF receptor alpha-subunit mRNA was also observed in the graft matrix and at lower levels in the ...and ...
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Inhibition of the platelet derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines
... two receptor subtypes show different affinities for the dimeric PDGF ...PDGF-alpha receptor binds with high affinity all three forms ...PDGF B-chain mRNA and little or no PDGF beta- receptor ...
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The Bovine Papillomavirus E5 Protein Requires a Juxtamembrane Negative Charge for Activation of the Platelet-Derived Growth Factor β Receptor and Transformation of C127 Cells
... endogenous platelet-derived growth factor (PDGF) b receptor through transmembrane and juxtamembrane interactions, leading to sustained receptor ...PDGF b ...
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B cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle like cells in the skin
... depletes B cells but it is not known how this drug may mediate its beneficial effect on ...fibrosis. Platelet-derived growth factor (PDGF) is a pivotal mediator of fibrosis; it has ...
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Function and regulation of Platelet-Derived Growth Factor Receptor Alpha during development
... Active PDGF is composed of dimers of A and B chains. All three dimeric isoforms of PDGF (AA, AB, BB) can bind to and activate PDGFRa in vitro. It is generally thought that, of these, PDGF-AA is the major ligand ...
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Inhibition of the platelet-derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines
... two receptor subtypes show different affinities for the dimeric PDGF ...PDGF-alpha receptor binds with high affinity all three forms ...PDGF B-chain mRNA and little or no PDGF beta- receptor ...
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Structural analysis of platelet-derived growth factor receptor alpha by protein homology modeling
... Verhaak, R. G. W., Hoadley, K. A., Purdom, E., Wang, V., Qi, Y., Wilkerson, M. D., Miller, C. R., Ding, L., Golub, T., Mesirov, J. P., Alexe, G., Lawrence, M., O'kelly, M., Tamayo, P., Weir, B. A., Gabriel, S., ...
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Evaluation of effectiveness of concentrated growth factor on osseointegration
... many growth factors such as bone morphogenetic protein (BMP), platelet-derived growth factor (PDGF), insulin-like growth factor (IGF), vascular endothelial growth ...
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Growth factor levels in leukocyte-poor platelet-rich plasma and correlations with donor age, gender, and platelets in the Japanese population
... in platelet α-granules and GFs and glycoproteins (adhesion factors) contained in the plasma, while maintaining an equilibrium in vivo (Alsousou et ...and platelet counts in ...and platelet counts in ...
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Rationale for targeting VEGF, FGF, and PDGF for the treatment of NSCLC
... epidermal growth factor receptor and vascular endothelial growth factor (VEGF) signaling ...tumor growth and metastasis, antiangiogenic treatments might be expected to have ...
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Growth factor induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model
... polypeptide growth factors in promoting wound healing and in directing the specificity and sequence of responses of different tissues in wounds are little ...four growth factors on the rates of healing of a ...
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Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers
... cell growth, proliferation, survival, and motility, and also regulate the epithelial – mesenchymal transi- tion (EMT) with a strong impact on the development of metas- ...
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Mesenchymal stem cells induce endothelial cell quiescence and promote capillary formation
... activation and was used as a predictor of mouse specific endothelial activation. At the end of the three-week experimental period the expression was higher for mono-cultured ECs, which correlated with the largest ...
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Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms
... a receptor tyrosine kinase protein array to determine if not only PDGFR-β, but also other similar receptors, might be regulated at the protein ...2, B and ...
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Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRβ Aptamer
... show limited specificity and modest efficacy whereas no antibodies have entered the clinic. This study reports, for the first time, an innovative therapeutic tool, an anti-PDGFRβ aptamer [19, 20] able to prevent BM-MSC ...
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Growth factor expression in aorta of normotensive and hypertensive rats
... of platelet-derived growth factor (PDGF) B chain and PDGF A chain, insulin-like growth factor (IGF)-I and IGF-II, endothelial cell growth factor (ECGF), ...
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An NMR study into the structure and interactions of the transmembrane domains of Neu and PDGFβ receptor tyrosine kinases
... signal transduction, where cytoplasmic factor(s) may induce transmembrane rota- tions in reverse direction to those of ‘outside-in’ signalling (Maruyama, 2015). Mutations in RTKs and other biological processes ...
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