Platelet factor 4
Modulation of heparin cofactor II activity by histidine rich glycoprotein and platelet factor 4
... Heparin cofactor II is a plasma protein that inhibits thrombin rapidly in the presence of either heparin or dermatan sulfate. We have determined the effects of two glycosaminoglycan- binding proteins, i.e., ...
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Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection
... transcription factor expression, which is driven by positive and negative cytokine and chemokine stimuli at the time of T cell ...chemokine platelet factor 4 (PF4) is a negative regulator of ...
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Platelet Factor 4 Is Highly Upregulated in Dendritic Cells after Severe Trauma
... that platelet factor 4 (PF4) is significantly upregulated in DCs in patients after multiple ...d 4 after trauma in patients compared with ...
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Capability of Platelet Factor 4 to Induce Apoptosis in the Cancerous Cell Lines in Vitro
... Platelet is one of the most important elements in the hemostasis and maintenance of vascular integrity [1]. In addition to different surface receptors interacting with coagulation cascade and endothelial cells, it ...
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Thrombin generation and secretion of platelet Factor 4 during blood clotting
... of platelet Factor 4 secretion occurs. Release of platelet Factor 4, like fibrin formation, occurs in the last step of in vitro ...
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Clinical and laboratory characteristics associated with a high optical density anti-platelet factor 4 ELISA test
... Purpose: Diagnosing heparin-induced thrombocytopenia, a potentially catastrophic immune- mediated disorder, continues to pose significant challenges for clinicians, as both clinical and laboratory tools lack specificity. ...
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Platelet factor 4 impairs the anticoagulant activity of activated protein C
... Platelet factor 4 (PF4) is an abundant platelet ␣ -granule che- mokine released following platelet ...recombinant factor Va variants FVa-R506Q/ R679Q and FVa-R306Q/R679Q, PF4 was ...
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Relationship between Secretion of Platelet Factor 4 and Thrombin Generation during In Vitro Blood Clotting
... prostaglandin E 1 and N 6 O 2¢ -dibutyryl cyclic AMP was added, secretion of platelet Factor 4 was inhibited 85-95%. We were unable to detect any inhibition of initiation of prothrombin activation or ...
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Immunocytochemical localization of fibrinogen, platelet factor 4, and beta thromboglobulin in thin frozen sections of human blood platelets
... of platelet factor 4 and beta ...for platelet factor 4, beta thromboglobulin, and fibrinogen localized exclusively over alpha-granules of washed ...
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Platelet factor 4 modulates the mitogenic activity of basic fibroblast growth factor
... growth factor (bFGF) has been shown to stimulate cell proliferation after vascular ...of platelet factor 4 (PF 4) and other platelet heparin-binding proteins to modulate ...
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Stimulation of histamine release from human basophils by human platelet factor 4
... Human basophils were stimulated to release histamine noncytotoxically by purified human platelet factor 4 (PF4) and the synthetic substituent peptide PF4(59-70). Histamine release was augmented ...
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CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration
... CXCL Platelet Factor Deposition of CXCL onto the vascular endothelium is involved in atherosclerosis facilitating monocyte arrest and recruitment by an as yet unidenti ed receptor Here we demonstrate that ...
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Inhibition of human megakaryocytopoiesis in vitro by platelet factor 4 (PF4) and a synthetic COOH terminal PF4 peptide
... approximately 58% in cultures containing recombinant human IL 3 and granulocyte- macrophage colony-stimulating factor. Because PF4 (25 micrograms/ml) had no effect on either myeloid or erythroid colony formation ...
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Platelet Factor 4 And Von Willebrand Factor Form An Immunogenic, Prothrombotic Complex In Heparin-Induced Thrombocytopenia
... Chapter 4 and Chapter 5 summarize our understandings of how vascular and intravasular cells and proteins contribute to the pathogenesis of ...Chapter 4 summarizes our finding that VWF released from injured ...
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The effect of phospholipase C on human blood platelets
... Total platelet factor 3 releasable by freezing and thawing was ...releasable platelet factor 4 and the efflux of serotonin showed that no release reaction was triggered even when up to ...
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Contribution of blood platelets to vascular pathology in Alzheimer's disease
... AD. Platelet activation and consequent degranulation can result in the secretion of numerous biological mediators that are mainly stored in platelet α granules (Table ...(CTAP-III), platelet ...
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Chemokine and inflammatory cytokine changes during chronic wound healing
... Wound fluids extracted from dressings showed high levels of platelet factor-4 and interferon-y-inducible protein, with a trend toward increases in the ratio of the sums of the angiogenic[r] ...
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Apixaban for treatment of confirmed heparin-induced thrombocytopenia: a case report and review of literature
... Background: Heparin‑induced thrombocytopenia (HIT) is a life and limb‑threatening condition caused by the binding of platelet‑activating antibodies (IgG) to multimolecular platelet factor 4 ...
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Platelet Rich Plasma Intra Articular Injection for Chronic Synovitis Treatment in Patients with Haemophilia One Year Follow Up
... [5]. Platelet-rich plasma (PRP) is used to stimulate healing of the joint and provide symptomatic relief ...[9,10]. Platelet derived growth factor (PDGF), transforming growth factor β1 ...
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Platelet alpha granule fibrinogen, albumin, and immunoglobulin G are not synthesized by rat and mouse megakaryocytes
... the platelet precursor cell, the bone marrow megakaryocyte, is the major source of platelet alpha-granule ...synthesize platelet factor 4, a protein relatively specific for platelets, ...
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