Pluripotent stem cells
Hydrodynamic modulation of pluripotent stem cells
... Controlled expansion and diff erentiation of pluripotent stem cells (PSCs) using reproducible, high-throughput methods could accelerate stem cell research for clinical therapies. Hydrodynamic ...
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Generation of induced pluripotent stem cells from large domestic animals
... Induced pluripotent stem cells; OSKM: Oct4, Sox2, KFL4, and c-Myc; biPSCs: Bovine induced pluripotent stem cells; miPSCs: Mouse induced pluripotent stem ...
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Induced Pluripotent Stem Cells: History, Properties and Potential Applications
... induced pluripotent stem cells (iPSCs) has been met with much enthusiasm and hailed as a breakthrough discovery by the scientific and research communities amidst the divisive and ongoing debates ...
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Induced pluripotent stem cells in infections
... Induced pluripotent stem cellsare generated by the genetic reprogramming of somatic cells by certain factors which are important in producing an embryonic stem cell-like state with similar ...
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Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells
... their pluripotent characteristics, human induced pluripotent stem cells (iPSCs) possess great potential for therapeutic application and for the study of degenerative ...These cells are ...
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Pluripotency of induced pluripotent stem cells
... of pluripotent stem cell via the ectopic expression of only four transcription fac- tors, namely Oct4, Sox2, Klf4 and ...customized pluripotent stem cells termed somatic cell nuclear ...
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Making gametes from pluripotent stem cells – a promising role for very small embryonic-like stem cells
... including pluripotent stem cells (embryonic ES and induced pluripotent iPS stem cells); gonadal stem cells (spermatogonial SSCs, ovarian OSCs stem ...
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Mouse induced pluripotent stem cells
... iPS cells may be to down-regulate p53 and counteract this pro- apoptotic effect of c-Myc (Rowland et ...transforming cells, c-Myc may also play a role in loosening chromatin ...as pluripotent ...
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Induced pluripotent stem cells: An update
... The efficiency of induction is increased by many additional genes which have been identified as members of the Klf family such as Klf1, Klf2, Klf4, and Klf5; the Myc family such as c-myc, L-myc, and N-myc; Nanog, and ...
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Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells
... To test the effect of histamine on human cardiomyo- genesis, we directed hiPSCs to undergo stepwise differ- entiation into cardiomyocytes according to a classical protocol [30]. Briefly, hiPSCs were treated with GSK3-β ...
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3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders
... Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental disorder characterized by smaller brain, particularly affecting cerebral cortex size [41, 42]. Twelve genes have been implicated in MCPH and the ...
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PubMedCentral-PMC5831028.pdf
... Human pluripotent stem cells (hPSCs) and their CNS derivatives present a model system for the study of brain development (Shi et al., 2012) and the generation of cell populations to understand and ...
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Stem cells: a model for screening, discovery and development of drugs
... cancerous stem cells and the recent advances made in isolation and culture of stem cells have rapidly gained attention in the field of drug discovery and regenerative ...using stem ...
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Mesenchymal stem cell-based cell-free strategies: safe and effective treatments for liver injury
... multipotent cells that are able to proliferate, self- renew, and differentiate into various somatic cells in vitro, and they have attracted much attention for re- storing tissue function in vivo with little ...
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A SY Stematic approach towards understanding stem cell biology
... various stem cell research ...how stem cells make ‘ decisions ’ during early development and how stem cells function in the ...embryonic stem cells (ESCs), induced ...
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Stem Cell Sources for Regenerative Medicine and Cartilage Tissue Engineering.
... Stem cells have been studied widely as a potential resource for regenerative medicine as they can proliferate for long-term while maintaining differentiation ...of cells and tissues within body. ...
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Making gametes from alternate sources of stem cells: past, present and future
... um), pluripotent stem cells, obtained by gentle scraping of ovary surface epithelium (OSE), into oocyte-like structures [28, ...epithelial cells smears which on 3 weeks culture, spontaneously ...
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p53 switches off pluripotency on differentiation
... mouse cells and 4 weeks for human ...somatic cells into iPSCs oc- curred at an extremely low rate: approximately ...fibroblast cells were de-differentiated into pluripotent stem ...
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Mesenchymal stem cells repair germinal cells of seminiferous tubules of sterile rats
... Induced pluripotent stem cells (iPSCs) have the ability to differentiate directly into advanced germ cell lineages in vitro such as postmeiotic, spermatid-like cells without genetic ...
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Advances in Regenerative Medicine: From Stem Cells to Organoids
... used stem cells to develop substitute tissue/organs “ex vivo” with various degree of success, which the ultimate goal is to be trans- planted to replace a damaged organ ...various stem cells, ...
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