PML-D
NPM1 Mutant Mediated PML Delocalization and Stabilization Enhances Autophagy and Cell Survival in Leukemic Cells
... of PML has been intensively investigated in the context of suppression in ...of PML in NPM1-mutated leukemic ...that PML knockdown led to cell proliferation suppression and colony formation ability ...
16
The Human Cytomegalovirus IE1 Protein Antagonizes PML Nuclear Body-Mediated Intrinsic Immunity via the Inhibition of PML De Novo SUMOylation
... prevents PML de novo SUMOylation in ...of PML and inhibition of PML de novo ...on PML SUMOylation, we selected an induction time of 24 h for further experiments ...inhibits PML de novo ...
17
The Promyelocytic Leukemia Protein Does Not Mediate Foamy Virus Latency In Vitro
... Endogenous PML does not colocalize with Tas or ...overexpressed PML and FV Tas has been ob- served in cells that support lytic replication ...endogenous PML with the PML-binding region of Tas ...
7
Effects of Promyelocytic Leukemia Protein on Virus-Host Balance
... the PML effects described here and with high doses exhausting the adap- tive immune response capacity, thereby eliminating immuno- ...to PML expression) become critical ...the PML- deficient immune ...
9
Murine Gammaherpesvirus 68 Open Reading Frame 75c Tegument Protein Induces the Degradation of PML and Is Essential for Production of Infectious Virus
... out cells. In addition, previous results indicated that ORF75c might be expressed during the later phases of infection, con- sistent with its being a structural protein (4, 21, 39). Therefore, it may not play a ...
13
Directed evolution of a genetically encoded immobilized lipase for the efficient production of biodiesel from waste cooking oil
... that PML would be suitable for Cry3Aa fusion, since it expresses well in ...of PML, Dieselzyme 4 (DLZM4), with high MeOH tolerance had been identified by directed evolution of PML in its soluble ...
14
Use of Diffusion Weighted Imaging to Evaluate the Initial Response of Progressive Multifocal Leukoencephalopathy to Highly Active Antiretroviral Therapy: Early Experience
... of PML-associated IRIS on overall mortality is controversial, with some studies suggesting rates of mortality similar to those of non-IRIS patients; the condition is often associated with temporary and sometimes ...
5
Herpesvirus Saimiri Antagonizes Nuclear Domain 10-Instituted Intrinsic Immunity via an ORF3-Mediated Selective Degradation of Cellular Protein Sp100
... of PML either via acting as a SUMO-targeted ubiquitin ligase or via SUMO- independent ubiquitination ...of PML degradation, since an identical alteration of the Sp100 isoform expression could be detected in ...
13
An Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies
... targets PML-NBs and recruits its components in the absence of any other viral ...with PML-NBs of Ad genome complexes up to 4 hpi, it is unlikely that early viral gene expression is a major contributor to ...
11
Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection
... that PML does not control infection by Salmonella Typhi- murium, even though this pathogen was also shown to induce a decrease in the Ubc9 level ...putative PML-regulated genes induced during Salmonella ...
16
What is the risk of progressive multifocal leukoencephalopathy in patients with ulcerative colitis or Crohn’s Disease treated with vedolizumab?
... with PML development as the primary outcome measure and with sufficient power to demonstrate equivalence between vedolizumab-treated patients and those receiving ...of PML associated with vedolizumab, we ...
32
Role of the Promyelocytic Leukemia Protein PML in the Interferon Sensitivity of Lymphocytic Choriomeningitis Virus
... of PML, which is proapoptotic and antiproliferative (1). PML dysfunction leads to proliferation of undifferentiated myeloid cells, which is a hallmark of acute myelocytic leukemia ...(21). PML ...
5
Characteristics of progressive multifocal leukoencephalopathy clarified through internet-assisted laboratory surveillance in Japan
... of PML, the collec- tion and analysis of large amounts of clinical data are ...as PML develops in patients with various underlying disorders sporadically and infre- quently, a comprehensive surveillance of ...
9
Promyelocytic Leukemia Protein Is a Cell-Intrinsic Factor Inhibiting Parvovirus DNA Replication
... whether PML could also inhibit the production of wild-type AAV by producing wild-type AAV2 from an infectious clone, with or without PMLII overexpression, and assaying the levels of virus ...that PML also ...
12
Epstein-Barr Virus Nuclear Antigen 1 Hijacks the Host Kinase CK2 To Disrupt PML Nuclear Bodies
... of PML disruption by EBNA1 in which an EBNA1 protein associates with PML NBs by a mech- anism that is independent of its interaction with USP7 or ...single PML isoform that appears to be PML ...
11
A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics
... causes PML de-SUMOylation which abolishes the suppressor ac- tivity of PML on STAT3 ...the PML-NBs[110]. SENP2 co-localizes with PML-NBs and PML en- hances its ...from PML in ...
17
CD62L is not a reliable biomarker for predicting PML risk in natalizumab-treated R-MS patients
... of PML in a case-control ...pre-PML/ PML samples (figure 3). Each PML case (filled circles) was matched for age, sex, and number of infusions with samples from 3 to 5 natalizumab- treated ...
9
The role of PML ubiquitination in human malignancies
... (CK2)-dependent PML ubiquitination Besides CDK1/2, other kinases can also influence on PML ubiquitination and proteasomal ...phosphorylates PML at mul- tiple sites. Among them, S517 (S565 in ...
7
A higher order perfectly matched layer formulation for finite-difference time-domain seismic wave modeling
... order PML, it is important that the potential absorption benefit justifies the increase in com- putational ...(01–02) PML in which all model edges except those subject to a large percentage of evanescent ...
16
Rhesus Macaque Rhadinovirus Encodes a Viral Interferon Regulatory Factor To Disrupt Promyelocytic Leukemia Nuclear Bodies and Antagonize Type I Interferon Signaling
... to PML-NBs, including cell cycle regulation, antiviral defense, as sites where proteins are SUMO modified, and transcriptional regulation ...of PML-NBs have been shown to restrict herpesvirus infections. ...
21