pneumococcal protective protein A
Modified Opsonization, Phagocytosis, and Killing Assays To Measure Potentially Protective Antibodies against Pneumococcal Surface Protein A
... to pneumococcal capsular polysaccharide was modified to permit an evaluation of the protection-mediating antibodies to pneumococcal surface protein A ...the protective activity was readily ...
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PsrP, a Protective Pneumococcal Antigen, Is Highly Prevalent in Children with Pneumonia and Is Strongly Associated with Clonal Type
... multivalent protein vaccine that eschews the capsular polysaccharide ...which pneumococcal protein(s) should be included in any revised vaccine ...various pneumococcal determinants in invasive ...
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Characterization of Protective Mucosal and Systemic Immune Responses Elicited by Pneumococcal Surface Protein PspA and PspC Nasal Vaccines against a Respiratory Pneumococcal Challenge in Mice
... as protein stability in each environment, favoring ...different pneumococcal challenge models (7, 12, ...PspC protein-based vaccines maybe explained by the fact that we have removed residual ...
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Mucosal immunization with PspA (Pneumococcal surface protein A) adsorbed nanoparticles targeting the lungs for protection against pneumococcal infection
... for pneumococcal polysaccharide vac- cines and a promising candidate is Pneumococcal surface protein A ...be protective in pneumococcal challenge models of lethal infection and ...
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Maternal Antibodies to Pneumolysin but Not to Pneumococcal Surface Protein A Delay Early Pneumococcal Carriage in High-Risk Papua New Guinean Infants
... and pneumococcal surface protein A (PspA) are two conserved proteins that are expressed by vir- tually all ...wall-associated protein that plays a role in inhibiting complement-mediated opsonization ...
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Anti-protein immunoglobulin M responses to pneumococcus are not associated with aging
... to pneumococcal proteins have protective potential, the impact of age on levels of IgM antibodies to pneumo- coccal proteins in humans has not been ...against pneumococcal proteins in relation to ...
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Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection
... not protective when given alone, but when each was combined with YLN, the level of pro- tection increased significantly relative to that with YLN alone, indicating that the strongest protection is achieved by the ...
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C-reactive protein is essential for innate resistance to pneumococcal infection
... not protective. 24 Furthermore, pneumococcal surface protein A, the choline-binding bac- terial protein which is a major pneumococcal virulence factor, competes with CRP for binding to ...
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STUDY EFFECT OF HUMAN SERUM PROTEIN ON BIOFILM FORM BY STAPHYLOCOCCUS EPIDERMIDIS
... to pneumococcal surface protein A as a result of colonization; individuals who did not become colonized after inoculation had preexisting antibodies to this protein, in sessile cells, SesC are a ...
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A Bivalent Vaccine Based on a Replication-Incompetent Influenza Virus Protects against Streptococcus pneumoniae and Influenza Virus Infection
... Streptococcus pneumoniae is a major causative pathogen in community-acquired pneumonia; together with influenza virus, it represents an important public health burden. Although vaccination is the most effective ...
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Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany
... that pneumococcal men- ingitis caused by non-PCV7 serotypes was associated with a lower lethality than PCV7 serotypes, while the incidence of neurological deficits was the same in both groups ...by ...
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Neuraminidase activity in bacterial meningitis
... The relation of neuraminidase to morbidity and mortality was examined in patients with Haemophilus influenzae, meningococcal, and pneumococcal meningitis. Ten strains of H. influenzae and eight strains of ...
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Rapid Detection of Penicillin Resistant Streptococcus pneumoniae in Cerebrospinal Fluid by a Seminested PCR Strategy
... Streptococcus pneumoniae (the pneumococcus) is the most common cause of acute community-acquired bacterial pneu- monia and accounts for 30 to 40% of lower respiratory tract infections (35). It is the second most common ...
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Evolution of Streptococcus pneumoniaeSerotypes and Antibiotic Resistance in Spain: Update (1990 to 1996)
... The surveillance in Spain of Streptococcus pneumoniae iso- lated in hospitals from different regions of the country was initiated in our laboratory in 1979. In that year we found that 6% of the pneumococci isolated from ...
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Muscle protein waste in tumor bearing rats is effectively antagonized by a beta 2 adrenergic agonist (clenbuterol) Role of the ATP ubiquitin dependent proteolytic pathway
... Tissue protein hypercatabolism (TPH) is a most important feature in cancer cachexia, particularly with regard to the skeletal muscle. The rat ascites hepatoma Yoshida AH-130 is a very suitable model system for ...
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Evaluation of protective efficacy using a nonstructural protein NS1 in DNA vaccine–loaded microspheres against dengue 2 virus
... the protein in its native ...denatured protein from the microsphere may result in an unwanted immune ...NS1 protein achieved through the presentation of NS1 protein inside PLGA/PEG 2:1 ...NS1 ...
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Role of pneumococcal vaccination in prevention of pneumococcal disease among adults in Singapore
... adult pneumococcal disease ...regarding pneumococcal disease and improved vaccine availability may contribute to a reduction in pneumococcal disease through increased vaccination ...reducing ...
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Recurrent severe invasive pneumococcal disease in an adult with previously unknown hyposplenia
... Table 2 Recommended immunizations against invasive pneumococcal disease using the 13-valent pneumococcal conjugate vaccine PCV13 and the 23-valent pneumococcal polysaccharide vaccine PPV[r] ...
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Cost effectiveness analysis of pneumococcal conjugate vaccine 13 valent in older adults in Colombia
... A main strength of this study is that it has local informa- tion, which helps determine the epidemiological parameters for diseases of interest in Colombia [31]. Also, medical costs of treatments are based on local data ...
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Serologic response to pneumococcal vaccination in children experiencing recurrent invasive pneumococcal disease
... From this registry all children aged 0–15 years with laboratory-confirmed IPD from January 1980 through June 2013 were identified and children with recurrent IPD (rIPD) in the period were included in the study (Fig. 1), ...
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