pneumococcal Surface Protein A
Correlation between In Vitro Complement Deposition and Passive Mouse Protection of Anti-Pneumococcal Surface Protein A Monoclonal Antibodies
... several surface-associated proteins have been demon- strated to be involved in pneumococcal virulence, and one such protein is pneumococcal surface protein A (PspA) ...the ...
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Mucosal immunization with PspA (Pneumococcal surface protein A) adsorbed nanoparticles targeting the lungs for protection against pneumococcal infection
... for pneumococcal polysaccharide vac- cines and a promising candidate is Pneumococcal surface protein A ...in pneumococcal challenge models of lethal infection and pneumonia ...lethal ...
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Maternal Antibodies to Pneumolysin but Not to Pneumococcal Surface Protein A Delay Early Pneumococcal Carriage in High-Risk Papua New Guinean Infants
... and pneumococcal surface protein A (PspA) are two conserved proteins that are expressed by vir- tually all ...wall-associated protein that plays a role in inhibiting complement-mediated ...
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A longitudinal study of natural antibody development to pneumococcal surface protein A families 1 and 2 in Papua New Guinean Highland children: a cohort study
... USA) pneumococcal conjugate vaccines (PCVs) are effective in reducing URT carriage and preventing inva- sive disease caused by vaccine serotypes, but result to some extent in replacement carriage with non-vaccine ...
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Impaired Function of Antibodies to Pneumococcal Surface Protein A but Not to Capsular Polysaccharide in Mexican American Adults with Type 2 Diabetes Mellitus
... after pneumococcal vaccination indicated that antibody titers in individuals with and individuals without diabetes were comparable in magnitude (27); however, patients with diabetes showed a delayed response to ...
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Modified Opsonization, Phagocytosis, and Killing Assays To Measure Potentially Protective Antibodies against Pneumococcal Surface Protein A
... to pneumococcal capsular polysaccharide was modified to permit an evaluation of the protection-mediating antibodies to pneumococcal surface protein A ...not pneumococcal surface ...
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Cloning, expression, purification and in silico analysis of n terminal domain of pneumococcal surface protein a from all six clades
... by pneumococcal strains, vaccination represents the most effective strategy for preventing pneumococcal ...the pneumococcal infection. Pneumococcal vaccines that are currently available are ...
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Conjugation of Polysaccharide 6B from Streptococcus pneumoniae with Pneumococcal Surface Protein A: PspA Conformation and Its Effect on the Immune Response
... carrier protein for PS6B and whether the conjugation would disrupt rPspA1’s structure, affecting its immu- ...that surface PspA1, contrary to rPspA1, interacts with other pneumococcal surface ...
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A Bivalent Vaccine Based on a Replication-Incompetent Influenza Virus Protects against Streptococcus pneumoniae and Influenza Virus Infection
... choline-binding protein A and pneumococcal surface adhesin A, are considered attractive anti- gens for a new vaccine (1, 2, 9, ...them, pneumococcal surface protein A (PspA) is ...
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Anti-protein immunoglobulin M responses to pneumococcus are not associated with aging
... the pneumococcal surface protein A (PspA) and an unencapsulated pneumococcal strain in serum isolated from hospital patients aged < 60 and ≥ 60, with and without lower respiratory tract ...
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Characterization of Protective Mucosal and Systemic Immune Responses Elicited by Pneumococcal Surface Protein PspA and PspC Nasal Vaccines against a Respiratory Pneumococcal Challenge in Mice
... Pneumococcal surface protein A (PspA) and PspC are virulence factors that are involved in the adhesion of Streptococcus pneumoniae to epithelial cells and/or evasion from the immune ...with ...
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Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection
... the pneumococcal proteins pneumolysin (Ply), choline binding protein A (CbpA), or pneumococcal surface protein A (PspA) elicits protective responses against invasive pneumococcal ...
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Genetic antigen diversity and gene flux among meningitic and bacteraemia-associated pneumococci from Malawi
... facilitating pneumococcal colonisation [132, ...choline-binding protein E (CbpE) [122, 139], pneumococcal adhesion and virulence A (pavA) [122, 124], pneumococcal surface protein ...
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The immunological mechanisms that control pneumococcal carriage
... In a study using a 23F type human challenge model, increased baseline antibody levels against pneumococcal surface protein A (PspA) were found in individuals protected against acquisitio[r] ...
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C-reactive protein is essential for innate resistance to pneumococcal infection
... Furthermore, pneumococcal surface protein A, the choline-binding bac- terial protein which is a major pneumococcal virulence factor, competes with CRP for binding to bacterial phos- ...
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STUDY EFFECT OF HUMAN SERUM PROTEIN ON BIOFILM FORM BY STAPHYLOCOCCUS EPIDERMIDIS
... to pneumococcal surface protein A as a result of colonization; individuals who did not become colonized after inoculation had preexisting antibodies to this protein, in sessile cells, SesC are ...
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Age-Specific Immunoglobulin G (IgG) and IgA to Pneumococcal Protein Antigens in a Population in Coastal Kenya
... conserved pneumococcal proteins—pneumolysin, pneumococcal sur- face adhesin A (PsaA), and pneumococcal surface protein A (PspA)—are currently being investigated as vac- cine ...Such ...
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Invasive and Noninvasive Streptococcus pneumoniae Capsule and Surface Protein Diversity following the Use of a Conjugate Vaccine
... 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in the United States in 2010 for the prevention of invasive pneumococcal disease (IPD) and otitis ...and surface protein genes ...
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Immunization with Pneumococcal Surface Protein K of Nonencapsulated Streptococcus pneumoniae Provides Protection in a Mouse Model of Colonization
... licensed pneumococcal vaccines (3). Pneumococcal vaccines target specific pneumococcal polysaccharide serotypes, 23 in Pneumovax (Pneumovax 23 [PPSV23]; Merck, Whitehouse Station, NJ, USA) and 13 in ...
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Multilocus Sequence Types, Serotypes, and Variants of the Surface Antigen PspA in Streptococcus pneumoniae Isolates from Meningitis Patients in Poland
... of pneumococcal capsular polysaccharides (17), the currently available antipneumococcal vaccines based on these compounds provide protection against only a limited number of ...of pneumococcal ...
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