Pokeweed mitogen
Proliferative signals for suppressor T cells Helper cells stimulated with pokeweed mitogen in vitro produce a suppressor cell growth factor
... To define molecular signals elaborated by inducer populations supporting growth or differentiation of T8+ cells, we collected supernatants of pokeweed mitogen (PWM)- stimulated cultures depleted of T8+ ...
8
Analysis of helper activity on pokeweed mitogen and interleukin 2 driven immunoglobulin synthesis by neoplastic T4+ cells
... The neoplastic T cells of a series of seven patients with chronic T-cell neoplasia were tested for helper activity on pokeweed mitogen (PWM)-induced and interleukin 2 (IL-2)- induced Ig synthesis. The ...
6
Implications for the role of cognate interactions in in vitro human B cell activation by Staphylococcus aureus Cowan I and pokeweed mitogen
... Human B cell-triggering mechanisms were investigated using the polyclonal activators Staphylococcus aureus Cowan I (SAC) and pokeweed mitogen (PWM). When the cultures of B cells, T cells, and monocytes were ...
8
Endotoxin Contamination in Commercially Available Pokeweed Mitogen Contributes to the Activation of Murine Macrophages and Human Dendritic Cell Maturation
... Pokeweed mitogen (PWM), a lectin with mitogenic activities, is obtained as a crude extract from roots of pokeweed, Phytolacca americana. For several decades, PWM has been investigated as a ...
5
Synthesis of immunoglobulin G by pokeweed mitogen or Epstein Barr virus stimulated human B cells in vitro is restricted to the ecto 5' nucleotidase positive subset
... To determine whether this enzyme defines functional subsets of B lymphocytes, human peripheral blood B cells, separated into ecto-5'-NT positive and negative populations by using goat an[r] ...
5
Dysfunctions of Pokeweed Mitogen stimulated T and B Lymphocyte Responses Induced by Gammaglobulin Therapy
... The suppressor activity of to allogeneic total leukocyte cultures did not affect pro- E+ or EAy- leukocytes from yG-treated chilliferations and B cell maturation, the same cell popula- d[r] ...
12
In Vivo and In Vitro Immunomodulatory Effects of Indian Ayurvedic Herbal Formulation Triphala on Experimental Induced Inflammation
... like mitogen such as phytohaemaglutinin (PHA), concanavalin A, pokeweed mitogen etc and enter into cell ...Then mitogen acts first by binding to cell surface receptor which in turn, initiates ...
10
Impaired Lymphocyte Transformation in Hodgkin's Disease EVIDENCE FOR DEPLETION OF CIRCULATING T LYMPHOCYTES
... The kinetics of lymphocyte transformation induced by phytohemagglutinin PHA and pokeweed mitogen PWM were studied daily, with blood lymphocytes from normal individuals and from untreated[r] ...
11
Inhibition of humoral and cell mediated immune responses in man by distinct suppressor cell systems
... subsets. Mitogen-activated suppressor cells were simultaneously assayed for their ability to inhibit (a) pokeweed mitogen-induced generation of plasma cells, (b) blastogenic response of lymphocytes ...
8
Interleukin 2-regulated in vitro antibody production following a single spinal manipulative treatment in normal subjects
... by pokeweed mitogen or human recombinant interleukin-2 stimulation were comparable in all ...of pokeweed mitogen-induced immunoglobulins were observed during the post-treatment period in any ...
8
Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease
... and pokeweed mitogen-stimulated cells over a 7-d period were determined in a solid-phase ...with pokeweed mitogen was markedly reduced in patients with Hodgkin's disease, whereas the mean ...
9
CNS activity of Pokeweed Anti viral Protein (PAP) in mice infected with Lymphocytic Choriomeningitis Virus (LCMV)
... 34. Uckun FM, Haissig S, Ledbetter JA, Fidler P, Myers DE, Kuebelbeck V, Weisdorf D, Gajl-Peczalska K, Kersey JH, Ramsay NK: Develop- mental hierarchy during early human B-cell ontogeny after autologous bone marrow ...
7
Restriction beyond the restriction point: mitogen requirement for G2 passage
... cyclin-associated kinase activities in G 1 that can be modu- lated by the stability of the cyclin subunit, as is the case for CYCLIN D, or by inhibition of the kinase activity, as is the case for CYCLIN E/CDK2. CYCLIN D ...
5
The Pokeweed Antiviral Protein Specifically Inhibits Ty1-Directed +1 Ribosomal Frameshifting and Retrotransposition in Saccharomyces cerevisiae
... codon, then the ribosomal frameshift can become established. The 29-kDa pokeweed antiviral protein (PAP) isolated from Phytolacca americana is a ribosome-inactivating protein (RIP). PAP catalytically removes a ...
7
Mast cell tryptase is a mitogen for cultured fibroblasts
... Mast cells appear to promote fibroblast proliferation, presumably through secretion of growth factors, although the molecular mechanisms underlying this mitogenic potential have not been explained fully by known mast ...
8
English_unc_0153D_14626.pdf
... Mitogen activated protein kinase (MAPK) pathways are dynamic signaling modules present. in all eukaryotic cells[r] ...
141
Release of Prostaglandin by Mitogen and Antigen Stimulated Leukocytes in Culture
... of mitogen- and antigen-stimulated leukocyte cultures was examined by a radioimmunoassay procedure empolying an antiserum reactive with PGB 1 and PGB 2 , the alkaline dehydration products of PGE and ...h, ...
10
Mitogen-Activated Protein Kinase Pathways and Fungal Pathogenesis
... as mitogen-activated protein (MAP) kinases (MAPKs) is involved in the transduction of a variety of extra- cellular signals and the regulation of different developmental ...
14
Studies on the mechanism of action of the potent mitogen Pasteurella multocida toxin
... There has been considerable interest in elucidating the signal transduction pathways involved in linking receptor occupancy and protooncogene induction. There is increasing evidence implicating PKC activation in the ...
219
A role for mitogen-activated protein kinase in epidermal hyperproliferation and inflammation
... Activation of ERK MAPK in suprabasal layers of mouse epidermis Several genes were found to have a moderately different expression between the two mice: the InvEE transgenic had in[r] ...
293