Poliovirus receptor
N glycosylation of the virus binding domain is not essential for function of the human poliovirus receptor.
... It seemed possible that differential glycosylation of hPVR Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest The human poliovirus receptor hPVR is a glycoprotein with thre[r] ...
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Transgenic mice carrying the human poliovirus receptor: new animal models for study of poliovirus neurovirulence.
... 681-688 0022-538X/94/$04.00 + 0 Copyright © 1994, American Society for Microbiology Transgenic Mice Carrying the Human Poliovirus Receptor: New Animal Model for Study of Poliovirus Neuro[r] ...
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Expression of the poliovirus receptor in intestinal epithelial cells is not sufficient to permit poliovirus replication in the mouse gut.
... of poliovirus replication in humans is the intestine, previously isolated transgenic mice which carry the human poliovirus receptor (PVR) gene (TgPVR mice), which develop poliomyelitis after ...
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The Poliovirus Empty Capsid Specifically Recognizes the Poliovirus Receptor and Undergoes Some, but Not All, of the Transitions Associated with Cell Entry
... The immunoprecipitation results, when interpreted in the context of the empty capsid structure, provide hints regarding the mechanism for conversion of the native mature virus to the cell entry intermediate. First, that ...
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The Toll-Like Receptor 3-Mediated Antiviral Response Is Important for Protection against Poliovirus Infection in Poliovirus Receptor Transgenic Mice
... (IL-1) receptor (TIR)-containing adaptor molecule 1, which is also known as TIR domain-containing adaptor induc- ing IFN- (TRIF), and finally results in the activation of IRF3 and IRF7 (13, 34, ...
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Establishment of a Poliovirus Oral Infection System in Human Poliovirus Receptor-Expressing Transgenic Mice That Are Deficient in Alpha/Beta Interferon Receptor
... occurred because hPVR in the liver causes the virus to repli- cate in MPVRTg25/IfnarKO mice. Indeed, we have reported previously that the liver in MPVRTg25 expresses hPVR (43). Moreover, the virus in the bloodstream can ...
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Kinetic Analysis of the Effect of Poliovirus Receptor on Viral Uncoating: the Receptor as a Catalyst
... virus- receptor complex requires a conformational adjustment that can only occur if the drug (or pocket factor) is expelled from the ...with receptor binding at low temperature (4°C) but not at room ...
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Molecular cloning and expression of a murine homolog of the human poliovirus receptor gene.
... A murine cDNA probe containing sequences encoding extracellular domains 2 and 3, the transmembrane region, and the NH2terminal half of the cytoplasmic tail hybridized with 2- and 3-kb mR[r] ...
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Characterization of the New World Monkey Homologues of Human Poliovirus Receptor CD155
... virus-receptor complexes on L-nCD155 cells, whereas virus-re- ceptor complexes were found on NZP-60 cells. This apparent discrepancy could be due to the lack of complexes that wild-type nCD155 can form in marmoset ...
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Excretion of Wild-Type and Vaccine-Derived Poliovirus in the Feces of Poliovirus Receptor-Transgenic Mice
... the poliovirus strains causing VAPP revealed that the attenuating mutations are lost by the accumulation of specific point mutations, either alone or in combination with intertypic recombination between the three ...
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Poliovirus specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor
... The findings demonstrate that Thl cells can mediate a protective immune response against poliovirus infection in vivo through helper activity for humoral immunity and that CD4 § T cells,[r] ...
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Human poliovirus receptor gene expression and poliovirus tissue tropism in transgenic mice.
... Although transgenic mouse kidney tissue expressed poliovirus binding sites and was not a site of poliovirus replication, when cultivated in vitro, kidney cells developed susceptibility t[r] ...
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Down regulation of poliovirus receptor RNA in HeLa cells resistant to poliovirus infection.
... Treatment of SOFIA cells with 5-azacytidine 5-azaC, a potent demethylating agent, resulted in partial restoration of susceptibility to * poliovirus infection, accompanied by increased le[r] ...
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Blockade of the Poliovirus-Induced Cytopathic Effect in Neural Cells by Monoclonal Antibody against Poliovirus or the Human Poliovirus Receptor
... Tolskaya et al. (35) reported that the CPE in human neu- roblastoma cells infected with virulent PV is suppressed by the addition of anti-PV hyperimmune serum shortly after the in- fection. They argued that the ...
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The human poliovirus receptor alpha is a serine phosphoprotein.
... Although we could not detect any inhibition of viral propagation upon treatment of JA-1 cells with the above-mentioned protein kinase inhibitors data not shown, these results obtained wi[r] ...
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Neutralization of Hepatitis A Virus (HAV) by an Immunoadhesin Containing the Cysteine-Rich Region of HAV Cellular Receptor-1
... cellular receptor-1 (havcr-1), a mucin-like type 1 integral-membrane glycoprotein of unknown natural ...the poliovirus receptor (PVR-Fc) and expressed them in CHO ...of poliovirus by PVR-Fc ...
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Allele-specific adaptation of poliovirus VP1 B-C loop variants to mutant cell receptors.
... the poliovirus receptor (Pvr), two in the predicted C * -C ( ridge and one in the D-E loop, abolish binding of the P1/Mahoney ...three receptor defects could be suppressed by a mutation in the VP1 ...
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Poliovirus variants selected on mutant receptor-expressing cells identify capsid residues that expand receptor recognition.
... the poliovirus receptor were previously shown to eliminate poliovirus ...expand receptor recognition, 16 poliovirus suppressor mutants were selected that replicate in three different ...
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Interaction of Poliovirus with Its Purified Receptor and Conformational Alteration in the Virion
... human poliovirus receptor (hPVR) were produced in a baculovirus expression ...of poliovirus type 1 was mixed with the purified PVRs in various ...
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Interaction of Poliovirus with Its Receptor Affords a High Level of Infectivity to the Virion in Poliovirus Infections Mediated by the Fc Receptor
... the poliovirus receptor (PVR), which functions to bind virus and to change its ...of poliovirus infection was ...g receptor molecules were established and used to study poliovirus ...
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