Polo-like kinase
Impact of Polo-like kinase 1 inhibitors on human adipose tissue- derived mesenchymal stem cells
... Polo-like kinase 1 (Plk1) has been established as one of the most promising targets for molecular anticancer ...Plk1 kinase domain inhibitors, and with Poloxin, the regulatory Polo-box ...
15
Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma
... of Polo-like kinase 1 (PLK-1) reduced the viability of ACC cell lines: Given that PLK-1 is a negative regulator of p53, inhibition of PLK-1 should reduce viability of the ACC cell ...
14
Immunohistochemical detection of Polo like kinase 1 (PLK1) in primary breast cancer is associated with TP53mutation and poor clinical outcome
... Introduction: Polo-like kinase-1 (PLK1) is a crucial driver of cell cycle progression and its down-regulation plays an important checkpoint role in response to DNA ...
11
Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy
... Polo-like kinase 1, a pivotal regulator of mitosis and cytokinesis, is highly expressed in a broad spectrum of tumors and its expression correlates often with poor prognosis, suggesting its potential ...
14
Original Article Polo-like kinase 1 controls cell proliferation regulated by miR-296-5p in ovarian cancer
... Abstract: Polo-like kinase 1 (PLK1) is overexpressed in various human cancers. However, the biological functions of PLK1 regulated by microRNAs in ovarian cancer are still unknown. The study is to ...
8
Mumps Virus Nucleoprotein Enhances Phosphorylation of the Phosphoprotein by Polo-Like Kinase 1
... The P proteins of paramyxoviruses are highly phosphorylated, and phosphorylation of these proteins has been shown to play critical roles in regulating viral mRNA synthesis (2–7). Phosphor- ylation of residues within the ...
11
Polo-like kinase 4 at the nexus of epigenetic modifications and the DNA damage signaling network
... with Polo-like kinase 4 Nucleophosmin/B23 (NPM/NPM1), also called numatrin or NO38, is a ubiquitous nucleolar phosphoprotein from the NPM family of proteins which also include NPM2 and NPM3 ...
217
Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1)
... in CML cells [4]. Here we used RNAi screening to look for sensitizers to the candidate cancer drug GSK461364A, a potent inhibitor of polo-like kinase 1 (PLK1) [5]. PLK1 is expressed during the G2/M ...
11
The activity regulation of the mitotic centromere-associated kinesin by Polo-like kinase 1
... The mitotic centromere-associated kinesin (MCAK), a potent microtubule depolymerase, is involved in regulating microtubule dynamics. The activity and subcellular localization of MCAK are tightly regulated by key mitotic ...
15
Polo-Like Kinase Guides Cytokinesis in Trypanosoma brucei through an Indirect Means
... Aurora kinase B and Polo-like kinase 1 (PLK1) are among the major protein kinases playing multiple roles in regulating both mitosis and ...
12
Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication
... human Polo-like kinase 1 (Plk1) was cloned in 1994, and its expression has been correlated with cell prolifera- tion ...a kinase domain on the amino-terminal region and a polo-box ...
7
Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors
... Aurora kinase A (AURKA)-Polo-like kinase 1 (PLK1)-FOXM1 axis is associated with the outcome of Imatinib (IM) resistance in an experimental model (K562 cell line) and bone marrow hematopoietic ...
11
<p>Polo-like kinase 1 inhibition in NSCLC: mechanism of action and emerging predictive biomarkers</p>
... tyrosine kinase inhibitors ...corresponding kinase inhibitors. In recent years, the Polo-like kinase (PLK) family has emerged as a key regulator in mitotic ...
14
Exploration of Mutation and DNA Methylation of Polo Like Kinase 1 (PLK1) in Colorectal Cancer
... Polo-like kinase is a serine/threonine kinase that promotes mitotic entry during cell division [1]. The overexpression of PLK1 is associated with poorer prognosis in many cancers [2], ...
13
Polo-Like Kinase 1 Is Involved in Hepatitis C Virus Replication by Hyperphosphorylating NS5A
... (human kinase and phosphatase genes) subset of VSV-G pseudotyped lentiviruses expressing distinct shRNA was employed for ...investigation. Polo-like kinase 1 (Plk1), a serine/ threonine ...
11
Henipavirus V Protein Association with Polo-Like Kinase Reveals Functional Overlap with STAT1 Binding and Interferon Evasion
... identified polo-like kinase 1 (PLK1) as being a Henipavirus P, V, and W protein-interacting ...phosphopeptide polo box domain (PBD) binding motifs with overlapping functions for both PLK1 and ...
13
A TAT-conjugated peptide inhibitor of polo-like kinase 1 for in vivo tumor imaging
... Gao X, Cui Y, Levenson RM, Chung LW, Nie S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol. 2004;22:969 – 76. Garcia-Alvarez B, de Carcer G, Ibanez S, Bragado-Nilsson E, Montoya G. ...
8
Habedanck, Robert (2006): The Human Polo-like Kinase 4 is a Regulator of Centrosome Duplication. Dissertation, LMU München: Fakultät für Biologie
... the polo-like kinase family is structurally similar to both Plk1 and 2 (Figure 5), and was originally identified as a fibroblast growth factor-inducible early response gene in NIH-3T3 cells (Donohue ...
124
Loss of p21 Cip1/CDKN1A renders cancer cells susceptible to Polo-like kinase 1 inhibition
... of Polo-like kinase 1 inhibitors, especially Poloxin, a specific inhibitor of the unique Polo-box ...with Polo-like kinase 1 inhibitors, p21 is increased in the cytoplasm, ...
16
Efficacy of the polo-like kinase inhibitor rigosertib, alone or in combination with Abelson tyrosine kinase inhibitors, against break point cluster region-c-Abelson-positive leukemia cells
... tyrosine kinase inhibitors (TKIs) against chronic myeloid leukemia (CML) has been ...a polo-like kinase (PLK) and phosphoinositide 3-kinase (PI3K) inhibitor, and ABL ...
10