Poloxamer 407
ANTIHYPERLIPIDEMIC AND ANTIOXIDANT ACTIVITY OF AERIAL PARTS OF SWERTIA CHIRATA (BUCH-HAM) IN POLOXAMER 407 INDUCED HYPERLIPIDEMIC RATS
... Hyperlipidemia is the major risk factors for the premature development of cardiovascular disease like atherosclerosis, hypertension, coronary heart disease etc. It is also an important risk factor in the initiation and ...
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Effect of Poloxamer 407 as a carrier vehicle on rotator cuff healing in a rat model
... of Poloxamer 407 as a carrier vehicle may be useful for promoting the early stages of the healing process and for maintaining the initial biomechanical properties of repaired rotator cuff ...with ...
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PRECLINICAL PHARMACOKINETIC EVALUATION OF EFAVIRENZ βCD POLOXAMER 407 PVP K30 INCLUSION COMPLEXES
... Pharmacokinetic evaluation was done on (i) Efavirenz; (ii) Efavirenz - βCD (1:2), (iii) Efavirenz – βCD (1:2) – Poloxamer 407(2%) and (iv) Efavirenz - βCD (1:2) - PVP K30 (2%) solid inclusion complexes in ...
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ENHANCEMENT OF DISSOLUTION RATE OF EFAVIRENZ EMPLOYING β -CYCLODEXTRIN, POLOXAMER 407 AND PVP K 30: A FACTORIAL STUDY
... Efavirenz was a gift sample from M/s. Eisai Pharmatechnology and Manufacturing Pvt. Ltd., Visakhapatham. β Cyclodextrin was gift sample from M/s. Cerestar Inc., USA. Methanol (Qualigens), poly vinyl pyrrolidone (PVP K30) ...
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DEVELOPMENT OF THERMOGELLING HYDROGELS BASED ON A POLOXAMER 407 / CHITOSAN MIXTURE FOR SKIN APPLICATION
... The objective of this study was to develop Poloxamer 407 / Chitosan mixtures. Thiolated or not for the treatment of certain skin ulcers like Buruli Ulcer after having synthesized 2- Iminothiolane or ...
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Poloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer
... and TPGS (23 mg) were dissolved in 3 mL acetonitrile in a round bottom flask. The solvent was evaporated by rotary evaporation at 40 ° C for 1 hour to obtain a solid GA/copolymer matrix. Residual acetonitrile remaining in ...
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DESIGN, DEVELOPMENT AND DISSOLUTION ENHANCEMENT OF SIMVASTATIN WITH POLOXAMER 407 BY KNEADING METHOD
... surfactants Poloxamer 407 at different concentrations and nine formulations were prepared kneaded for 30 minutes and characterized for percentage yield, drug content, solubility of solid dispersions in ...
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Influence of poloxamer 407 on fractional and subfractional composition of serum lipoproteins of mice
... Poloxamer 407 has been used in several fields of medi- cine as a nano-carrier for different drugs for the treat- ment of several inflammatory diseases and tumors ...of poloxamer 407 in the ...
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Pharmacokinetics and enhanced oral bioavailability in beagle dogs of cyclosporine A encapsulated in glyceryl monooleate/poloxamer 407 cubic nanoparticles
... During the sonication procedure, the cubic phase gel was efficiently disrupted. Particle size analysis gave a mean diameter of 200 - 300 nm and a wide particle size distribution ranging from 30 nm to 1000 nm (Figure 2A). ...
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“Formulation and Evaluation of Solid Dispersion Tablets of Poorly Water Soluble Drug Candesartan Cilexetil Using Poloxamer 407” by A. Seetha Devi, Divya Peddinti, Archana Pinnika, India.
... using Poloxamer 407 as a hydrophilic carrier in different ratios (1:1, 1:2, 1:3) by means of kneading method, solvent evaporation method and melting ...
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Early-stage atherosclerosis in poloxamer 407-induced hyperlipidemic mice: pathological features and changes in the lipid composition of serum lipoprotein fractions and subfractions
... Male CBA mice having a body mass of 25–30 g were used and obtained from the breeding station of the Institute of Physiology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. Poloxamer ...
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The Influence of Sam Chil Geun (Panax Notoginseng) on the Serum Lipid Levels and Inflammations of Rats with Hyperlipidemia Induced by Poloxamer 407
... groups, poloxamer-407 was ad- ministered at 3 day intervals, from the first day of the ex- periment until the 21st ...administration, poloxamer-407 was dissolved in saline and was kept refri- ...
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FORMULATION, EVALUATION AND CYTOTOXIC POTENTIAL OF METRONIDAZOLE LOADED POLOXAMER 407 HYDROGEL IN SCC 29 CELL LINES
... The cytotoxic activity of metronidazole (Flagyl) and imidazole (MISO) was conducted on hypoxic Chinese hamster ovary cells, and considerable cytotoxic activity was reported 7 . In another reported article it was ...
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Thermo-sensitive composite hydrogels based on poloxamer 407 and alginate and their therapeutic effect in embolization in rabbit VX2 liver tumors
... the poloxamer 407 ...the poloxamer 407 micelles form a close three-dimensional hydrophilic polymer networks, leading to a sol-to-gel phase ...packed poloxamer 407 ...
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A FACTORIAL STUDY ON FORMULATION DEVELOPMENT OF EFAVIRENZ TABLETS EMPLOYING Β CYCLODEXTRIN POLOXAMER 407 PVP K30
... complex (ab); EF – PVP K30 (2%) binary mixture (c); EF - βCD (1:2) – PVP K30 (2%) ternary complex (ac); EF – Poloxamer 407 (2%) - PVP K30 (2%) ternary complex (bc); EF - βCD (1:2)- Poloxamer ...
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Effects of temporary vascular occluder poloxamer 407 Gel on the endothelium
... P 407 group (Figure ...by Poloxamer 407 gel may not give rise to restenosis because in our experiment, ...by Poloxamer 407 gel, so the integrity of the endothelium was pre- ...P ...
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PERFORMANCE OF POLOXAMER 188 AND POLOXAMER 407 AS HYDROPHILIC CARRIER ON THE BINARY MIXTURES OF MESALAZINE
... A solid dispersion (SD) approach has been performed to enhance the dissolution rate of insoluble drugs by improving their aqueous solubility. An insoluble drug, Mesalazine was chosen as a model drug, non-steroidal anti- ...
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Development of Fast Dissolving Tablets of Nisoldipine by Solid Dispersion Technology using Poloxamer 407 and Poloxamer 188
... with poloxamer 188 and poloxamer 407 with aim of enhanced dis- solution ...nisoldipine poloxamer SD in the ratio of 1:5 prepared by solvent evaporation meth- ...
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Formulation Development and Characterization of Aceclofenac Gel Using Poloxamer 407
... The consistency reflects the capacity of the gel, to get ejected in uniform and desired quantity when the tube is squeezed. Consistency in terms of distance travel by cone was 8mm of all developed batches as compared to ...
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Budesonide-Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Poloxamer 407 and Poloxamer 407/403Systems: A Structural Study by Small Angle X-Ray Scattering (SAXS)
... β-CD), Poloxamer 403 (Pluronic® P-123) and Poloxamer 407 (Pluronic® F-127) were purchased from Sigma-Aldrich ...PL 407 (18 or 20 % m/v) isolated or in association with PL403 (at 2 % m/v), in ...
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