Poly(A)-binding protein
The poly(A) binding protein partner Paip2a controls translation during late spermiogenesis in mice
... spermiogenesis. Poly(A)-binding protein (Pabp) plays an important role in mRNA stabilization and translation. Three Pabp-interacting proteins, Paip1, Paip2a, and Paip2b, have been described. Paip2a ...
13
Poly(A)-Binding Protein Facilitates Translation of an Uncapped/Nonpolyadenylated Viral RNA by Binding to the 3′ Untranslated Region
... 3= poly(A) tail in their genomic ...the poly(A)-binding protein (PABP) as one of the key players in the 3=CITE-mediated translation of RCNMV ...3= poly(A) tail and the 5= cap of ...
14
Cleavage of Poly(A)-Binding Protein by Enterovirus Proteases Concurrent with Inhibition of Translation In Vitro
... cell protein synthesis during infection, a process referred to as host cell ...stimulatory protein, poly(A)-binding protein ...the poly(A) tail on mRNAs and has been proposed to ...
10
Efficient Cleavage of Ribosome-Associated Poly(A)-Binding Protein by Enterovirus 3C Protease
... cap-dependent protein synthesis during infection while preferentially allowing cap-independent translation of its own genomic RNA via an internal ribosome entry site ...and poly(A)-binding ...
13
Cleavage of Poly(A)-Binding Protein by Coxsackievirus 2A Protease In Vitro and In Vivo: Another Mechanism for Host Protein Synthesis Shutoff?
... 39-terminal poly(A) tract. Some of the known functions of the poly(A) tract include nucleocytoplasmic transport of mRNA (28), stabilization of cytoplasmic mRNA (12), and enhancement of mRNA transla- tion ...
9
Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs
... It is well known that polyadenylation efficiency discriminates stable, functional transcripts from rapidly degraded aberrant RNAs (37, 38). This predicts effects of PABPN1 and PAP deple- tion on RNA turnover. Indeed, ...
13
Translational Control of the Abundance of Cytoplasmic Poly(A) Binding Protein in Human Cytomegalovirus-Infected Cells
... cap-binding protein eIF4E, eIF4G, and the RNA heli- case eIF4A into the active, cap-binding, multisubunit transla- tion initiation factor eIF4F represents a key step regulating translation (reviewed ...
9
Hepatitis C Virus Internal Ribosome Entry Site-Dependent Translation in Saccharomyces cerevisiae Is Independent of Polypyrimidine Tract-Binding Protein, Poly(rC)-Binding Protein 2, and La Protein
... cap- binding protein eIF4E and the 5 ⬘ -cap structure of the ...internal binding of the 40S ribosomal subunit to an internal ribosome entry site (IRES) ...La protein (3), polypyrimidine ...
12
Cellular Protein Modification by Poliovirus: the Two Faces of Poly(rC)-Binding Protein
... cellular protein poly(rC)-binding protein (PCBP) was identified as a primary candidate for regulating such a ...functional protein-protein and RNA-protein complexes with ...
14
Presence of a Poly(A) Binding Protein and Two Proteins with Cell Cycle-Dependent Phosphorylation in Crithidia fasciculata mRNA Cycling Sequence Binding Protein II
... recombinant protein by using the wild-type RNA probe ...multiple binding of the protein molecules to the probe. Very little binding was observed with the mutant probe (containing 6⫻ CAUAGcAG), ...
13
Rubella Virus Capsid Protein Interacts with Poly(A)-Binding Protein and Inhibits Translation
... We next investigated whether PABP upregulation occurred in cells that are infected with other RNA viruses. As men- tioned above, it is well documented that PABP is an important FIG. 1. (A) COS cells were transiently ...
11
Functional Characterization of Three Leishmania Poly(A) Binding Protein Homologues with Distinct Binding Properties to RNA and Protein Partners
... RNA binding protein that binds to AU-rich sequences in the 3 ⬘ UTRs of mRNAs, which are selectively destabilized in the trypomastigote stage of the parasite ...PABP2 protein does not shuttle to the ...
11
Rotavirus NSP3 Is a Translational Surrogate of the Poly(A) Binding Protein-Poly(A) Complex
... eIF4G, poly(A) binding protein (PABP) facilitates the translation of 5=-capped and 3=-poly(A)-tailed ...viral protein NSP3, which competes with PABP for eIF4G ...host ...
10
Poly(C)-Binding Protein 1, a Novel Npro-Interacting Protein Involved in Classical Swine Fever Virus Growth
... specific binding to both RNA and ...DNA-binding protein that participates in neu- ronal -opioid receptor gene expression at the transcriptional level (21) and has been shown to be expressed ...
9
Specific nuclear binding of adenosine 3',5' monophosphate binding protein complex with subsequent poly(A) RNA synthesis in embryonic chick cartilage
... AMP binding proteins were further purified by DNA-cellulose ...stimulated poly(A) RNA synthesis in isolated ...AMP-binding protein was the predominant one that bound to the ...AMP-dependent ...
12
Nuclear Localization of Cytoplasmic Poly(A)-Binding Protein upon Rotavirus Infection Involves the Interaction of NSP3 with eIF4G and RoXaN
... FIG. 5. Fine mapping of the NSP3 RoXaN interaction domain in NSP3. (A) Fine mapping of the NSP3 RoXaN interaction domain in NSP3 by yeast two-hybrid assay. A schematic representation of NSP3 structural and functional ...
11
Interactions of Viral Protein 3CD and Poly(rC) Binding Protein with the 5′ Untranslated Region of the Poliovirus Genome
... in the presence of cellular proteins the cloverleaf and stem- loop IV RNA structures do not interact with each other. In- terestingly, the cloverleaf RNA was a poor competitor for the interaction of PCBP with stem-loop ...
8
Utilization of Poly(A)-Binding Protein in Monitoring the Formation of mRNP Granules in Toxoplasma gondii
... scaffold protein that binds to specific sequences of mRNA and interacts with other proteins to modulate the fate of mRNA and therefore regulate gene expression (Goss and Kleiman, 2013; Eliseeva et ...the ...
98
Site-Specific Cleavage of the Host Poly(A) Binding Protein by the Encephalomyocarditis Virus 3C Proteinase Stimulates Viral Replication
... eIF4E-binding protein 1 (4E-BP1), was also analyzed throughout the course of EMCV ...by binding to the cap-binding protein ...eIF4G binding to eIF4E and precludes the formation ...
9
Interplay between the Poly(A) Tail, Poly(A)-Binding Protein, and Coronavirus Nucleocapsid Protein Regulates Gene Expression of Coronavirus and the Host Cell
... fluorescent protein (EGFP); the construct was designated ...65-nt poly(A) tail was first incubated with various amounts of N protein ...the binding of N protein to the 65-nt ...
20