poly(A) binding protein 1
Control of mRNA stability contributes to low levels of nuclear poly(A) binding protein 1 (PABPN1) in skeletal muscle
... Nuclear poly(A) binding protein 1 (PABPN1) mRNA is unstable in muscle tissue but stable in cultured ...coactivator 1 α (PGC1 α ) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a ...
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Original Article Expression of poly(C)-binding protein 1 (PCBP1) in NSCLC as a negative regulator of EMT and its clinical value
... Abstract: Poly (C)-binding Protein 1 (PCBP1) is a 35 kDa protein involved in a number of biological processes. Recently, the research found that PCBP1 might be involved in ...
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Poly(C)-Binding Protein 1, a Novel Npro-Interacting Protein Involved in Classical Swine Fever Virus Growth
... vitro poly(rC)-binding activity of hnRNP-K can be assigned to KHIII, whereas both domains I and III in the PCBPs bind poly(rC) ...critical protein- protein interactions between PCBP1 ...
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RETRACTED ARTICLE: Downregulated Poly-C binding protein-1 is a novel predictor associated with poor prognosis in Acute Myeloid Leukemia
... clinical observations. Mechanistically, PCBP1 silence fa- cilitated androgen receptor (AR) protein expression by binding to the 3’ untranslated region (UTR) of AR mRNA in prostate cancer LNCap cells [34]. ...
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Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs
... intron 1 (Ex1-In1) and intron 2 (In2- Ex3), as well as spliced exons 1 and 2 (Ex1-Ex2) and spliced exons 2 and 3 (Ex2-Ex3) ...a poly(A) site does not support mRNA synthesis, which is con- cordant ...
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Translational Control of the Abundance of Cytoplasmic Poly(A) Binding Protein in Human Cytomegalovirus-Infected Cells
... Additional genetic evidence supporting a role for viral gene expression triggering increased host translation factor abun- dance was obtained using a well-characterized IE1-deficient virus (8). While IE1 is not essential ...
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Interplay between the Poly(A) Tail, Poly(A)-Binding Protein, and Coronavirus Nucleocapsid Protein Regulates Gene Expression of Coronavirus and the Host Cell
... the poly(A) tail and N protein with translation factor eIF4G and coronavirus replicase protein ...the poly(A) tail and N protein in gene regulation, we first determined whether the ...
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Poly(A)-Binding Protein Facilitates Translation of an Uncapped/Nonpolyadenylated Viral RNA by Binding to the 3′ Untranslated Region
... mimic poly(A) tail in 3=CITE-dependent ...of poly(A) tail to the 3= terminus stimulated cap-independent translation in the reporter RNA with the core BTE alone but did not in the reporter RNA with the long ...
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Efficient Cleavage of Ribosome-Associated Poly(A)-Binding Protein by Enterovirus 3C Protease
... on poly(A) RNA is not known; however, the footprint of PABP occupies about 25 nucleotides, and multiple PABP mol- ecules are oligomerized on poly(A) tails longer than 50 nucle- otides [up to eight or nine ...
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Presence of a Poly(A) Binding Protein and Two Proteins with Cell Cycle-Dependent Phosphorylation in Crithidia fasciculata mRNA Cycling Sequence Binding Protein II
... by 1 kb of 5⬘ and 3⬘ UTRs on either end, was obtained from a MluI digest of DNA of a clone that was found to contain the ...Recombinant protein expression and ...
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Utilization of Poly(A)-Binding Protein in Monitoring the Formation of mRNP Granules in Toxoplasma gondii
... scaffold protein that binds to specific sequences of mRNA and interacts with other proteins to modulate the fate of mRNA and therefore regulate gene expression (Goss and Kleiman, 2013; Eliseeva et ...the ...
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Cleavage of Poly(A)-Binding Protein by Enterovirus Proteases Concurrent with Inhibition of Translation In Vitro
... via protein factors binding specifically to these ...the poly(A)-binding protein (PABP) Pab1p, which interacts with the poly(A) tail present on most eukaryotic mRNAs, has been ...
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Interactions of Viral Protein 3CD and Poly(rC) Binding Protein with the 5′ Untranslated Region of the Poliovirus Genome
... abolished binding of PCBP in vitro (7), presumably by altering the structure at the base of loop ...PCBP binding site, we analyzed whether the sequences of loop a and loop b are functionally important for ...
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Rotavirus NSP3 Is a Translational Surrogate of the Poly(A) Binding Protein-Poly(A) Complex
... cellular poly(A) mRNA expres- sion, an MA104 cell line constitutively expressing a destabilized renilla luciferase (24) was ...observed 1 to 2 h after infection, probably due to a transient inhibition of ...
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Rubella Virus Capsid Protein Interacts with Poly(A)-Binding Protein and Inhibits Translation
... We next investigated whether PABP upregulation occurred in cells that are infected with other RNA viruses. As men- tioned above, it is well documented that PABP is an important FIG. 1. (A) COS cells were ...
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Functional Characterization of Three Leishmania Poly(A) Binding Protein Homologues with Distinct Binding Properties to RNA and Protein Partners
... RNA binding protein that binds to AU-rich sequences in the 3 ⬘ UTRs of mRNAs, which are selectively destabilized in the trypomastigote stage of the parasite ...PABP2 protein does not shuttle to the ...
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Cellular Protein Modification by Poliovirus: the Two Faces of Poly(rC)-Binding Protein
... lates during the course of infection. This species is not ob- served in the mock-infected samples. The abundance of full- length PCBP also remained constant in the mock-infected samples. These results support the ...
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Human immunodeficiency virus type 1 Rev is required in vivo for binding of poly(A)-binding protein to Rev-dependent RNAs.
... ARRIGO`* Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425-2230'; Howard Hughes Medical Institute, School of Medicine, Uni[r] ...
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Blastomyces Virulence Adhesin 1 Protein Binding to Glycosaminoglycans Is Enhanced by Protein Disulfide Isomerase
... high-frequency binding of BAD-1 to heparin would be initiated by the Cardin-Weintraub site located at the N-terminal end of the protein ...repeat binding to heparin (Fig. 1B). Enhanced ...
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The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A).
... Our results indicate that the NS1 protein would be expected to inhibit the nuclear export of all polyA-containing cellular and viral mRNAs in infected cells.. Why would this function of [r] ...
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