Poly(A)polymerase I
Autoantibody to RNA polymerase I in scleroderma sera
... anti-RNA polymerase I antibodies stained the same fibrillar structures in drug-segregated nucleoli as scleroderma ...anti-RNA polymerase I antibodies, and their common identities were ...
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Terminal Riboadenylate Transferase: a Poly A Polymerase in Purified Vaccinia Virus
... BOLLUM Department of Biochemistry, University of Kentucky, Medical Center, Lexington, Kentucky 40506 Received for publication 11 April 1973 The presence of RNA polymerase activity and th[r] ...
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DNA Polymerase in Virions of a Reptilian Type C Virus
... Imnmunological experiments also to assay the partially purified viral DNA polymerase suggested that the viper virus possesses a group- also contained 2 ug of the synthetic template poly [r] ...
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Asthma and poly(ADP-ribose) polymerase inhibition: a new therapeutic approach
... many poly(ADP-ribose) polymerase (PARP) inhibitors have been enrolled in clinical trials as a combination therapy for several types of cancer, and many of these were licensed by the Food and Drug ...
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Update on Poly ADP ribose polymerase inhibition for ovarian cancer treatment
... PARP-1 is recruited and activated by SSBs as a homodimer in a fast reaction and upon binding to a damaged strand; PARP-1 undergoes a conformational change inducing the C-terminal catalytic domain to transfer ADP-ribose ...
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Current status of poly(ADP-ribose) polymerase inhibitors and future directions
... of poly(ADP-ribose) polymerases (PARPs), which play a key role in DNA damage/repair pathways, have been developed as antitumor agents based on the concept of synthetic ...
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DNA Polymerase I-Dependent Mutants of Coliphage Lambda
... But mutants deficient in functions red and gam needed for recombination or for growth on recA- hosts fail to plate on polAl strains 23.. More specifically, a phage must be either reda+ o[r] ...
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CYTOTOXICITY AND IN SILICO STUDIES OF ANETHOLE IN TRIPLE NEGATIVE BREAST CANCER CELLS
... ADP-ribose polymerase) inhibitors, insulin- like growth factors (IGFs), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR) and G-protein coupled receptor (GPCR) are some of the ...
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Poly(A) Polymerase and the Nuclear Poly(A) Binding Protein, PABPN1, Coordinate the Splicing and Degradation of a Subset of Human Pre-mRNAs
... RNA polymerase II (Pol II) and assemble on introns during transcription (2, ...the poly(A) signal, as may be expected, since there is less time for splicing prior to CPA (5, 7, 8, ...
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RNA synthesis in 'Candida albicans'
... RNA polymerase activity eluted from DEAE-sephadex were termed RNA polymerases I, II and III according to the procedure of Roeder and Rutter (311) and Blatti et al (33 ...polymerases I, II and III ...
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RNA Polymerase III Defects Suppress a Conditional-Lethal Poly(A) Polymerase Mutation in Saccharomyces cerevisiae
... The indicated mRNA half-lives were determined from the slopes of these plots (HERRICK et al.. The region of chromosome Wcontaining RETl and nearby coding regions is depicted in [r] ...
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QSAR, Docking and Invitro Antioxidant Activity Study of Novel Chromone Derivatives
... against Poly (ADP-ribose) polymerase ...as Poly (ADP-ribose) polymerase inhibi- tors. This prompted us (i) to gain insight into the structural features related to the antioxidant ...
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Activation of the Poly(ADP-Ribose) Polymerase Pathway in Human Heart Failure
... increased poly(ADP-ribosyl)ation in human failing hearts ...increased poly(ADP-ribosyl)ation in our samples was most probably due to activation of the catalytic function of ...
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An update on PARP inhibitors for the treatment of cancer
... of poly (adenosine diphosphate [ADP]) ribose polymerase (PARP) inhibitors (PARPi) has progressed greatly over the last few years and has shown encouraging results in the BRCA1/2 mutation–related ...
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Sulfur mustard induces expression of metallothionein-1A in human airway epithelial cells
... transcriptase poly- merase chain reaction results, confirmed by quantitative real- time reverse transcriptase polymerase chain reaction, indicate that expression of MT-1A at the mRNA level was significantly ...
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Defective DNA repair mechanisms in prostate cancer: impact of olaparib
... aggressiveness. Poly adenosine diphosphate ribose polymerase (PARP) proteins play a key role in DNA repair mechanisms and represent a valid target for new ...
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Polyoma virus minichromosomes: poly ADP-ribosylation of associated chromatin proteins.
... Specific activities of polyADP-rib polymerase of HeLa cell nucleosomes and polyoma RI and mature chromatin Incorporation into histone fractionb Poly ADP-ribosylationa Source of chromatin[r] ...
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The poly(A) polymerase GLD2 is required for spermatogenesis in Drosophila melanogaster
... DAPI staining indicated that, in addition to the nuclear scattering phenotype, nuclei in elongated spermatocysts of GLD2 knockdown testes were less condensed than those of the wild type (Fig. 4C,D), suggesting a nuclear ...
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Poly(A) Polymerase Activity in Reovirus
... Properties of oligoA producta Percent TreatmentPecn acid soluble Pancreatic DNase 0 Ti + pancreatic RNase 0.3 M NaCl 0.01 M NaCl U2 RNase KOH' 0 51 97 >99 a Virions were incubated for 4 [r] ...
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Poly(A) Polymerase from Vaccinia Virus-Infected Cells I. Partial Purification and Characterization
... In contrast to these results, the enzyme preparation induced in vaccinia virus infected HeLa cells was minimally affected by polyA or polyC, strongly inhibited by polydT and maximally st[r] ...
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