polygenic risk score
Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis
... a polygenic contribution to schizophrenia ...quantitative polygenic risk score was ...this polygenic risk score between cases and controls in two independent schizophrenia ...
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Polygenic risk score for predicting weight loss after bariatric surgery
... of polygenic risk scores on postsurgery weight loss was a multivariable linear mixed model that returned a more comprehensive value of the actual genetic effect on ...between polygenic risk ...
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Polygenic risk score: use in migraine research
... comparing risk allele frequen- cies in cases against healthy controls ...the Polygenic Risk Score (PRS) is one way to assess the additive effect of several (associ- ated) ...
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Polygenic risk score in postmortem diagnosed sporadic early onset Alzheimer’s disease
... affect risk of LOAD (Lambert et ...AD risk genes not previously identified, including the TRIP4, SPPL2A genes (Ruiz et ...affect risk of AD previously not identified in GWAS (Giri et ...further ...
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Schizophrenia polygenic risk score: zooming-in on early, non-psychotic developmental expressions of vulnerability
... familial risk of schizo- phrenia carried an increased burden of trait-associated alleles using s-PRS, as well as the extent to which s-PRS was associated with gyral folding in the frontal and tem- poral ...milial ...
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Addition of a 161-SNP polygenic risk score to family history-based risk prediction: impact on clinical management in non-BRCA1/2 breast cancer families
... 3 Michailidou K, Hall P, gonzalez-neira a, ghoussaini M, Dennis J, Milne rl, Schmidt MK, chang-claude J, Bojesen Se, Bolla MK, Wang Q, Dicks e, lee a, turnbull c, rahman n, Fletcher O, Peto J, gibson l, dos Santos Silva ...
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Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk
... Adjusted percent density (PD) and dense area (DA) measures were positively associated with breast cancer across all studies (Additional file 1: Table S3). For ad- justed PD, there was a 1.45-fold increased risk ...
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Migraine polygenic risk score associates with efficacy of migraine-specific drugs
... We interviewed 2,219 unrelated patients at the Danish Headache Center using a semistructured interview to diagnose migraine and assess acute and prophylactic drug response. All patients were genotyped. A PRS was ...
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Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels
... This study was performed using samples from individuals with European ancestry from two PD datasets: the Parkinson’s Progression Markers Initiative (PPMI) and the Washington University in Saint Louis (WUSTL) Movement ...
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Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia
... and polygenic risk score analysis in a Greek sample collection (GOMAP) comprising three patient groups: SCZ only (n = 924), T2D only (n = 822), comorbid SCZ and T2D (n = 505); samples from two ...
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Zhao_unc_0153D_19397.pdf
... cross-trait polygenic risk score (PRS) method, which has gained popularity for assessing genetic correlation of complex traits using summary statistics from biobank-scale ...
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Genetic susceptibility to radiation-induced breast cancer after Hodgkin lymphoma.
... In the current study, we used a two-step design to investigate whether there are subgroups of women exposed to chest RT which are genetically more susceptible to radiation-induced breast cancer. We first used a case-only ...
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Assessing the incremental contribution of common genomic variants to melanoma risk prediction in two population-based studies
... environmental) risk factors overlap in their prediction of melanoma ...traditional risk factors, using data from two population-based case-control studies from Australia (n ¼ 1,035) and the United Kingdom ...
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Potential use of clinical polygenic risk scores in psychiatry – ethical implications and communicating high polygenic risk
... predict risk. Psychiatric disorders are highly heritable, but also polygenic, with genetic risk conferred by interactions between thousands of variants of small effect that can be summarized in a ...
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Polygenic risk scores in imaging genetics: Usefulness and applications
... increased risk for both ...or polygenic architecture of psychiatric disorders as the amount of phenotypic variation explained by each GWAS-supported SNP is small whereas the number of SNPs/regions ...
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A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder
... increased risk for both ...a polygenic risk score (PGRS) for each ...the polygenic architecture of psychotic disorders is not regionally confined but impacts on the task-dependent ...
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Large-scale Analysis Demonstrates Familial Testicular Cancer to have Polygenic Aetiology.
... eightfold risk to male relatives of TGCT ...present polygenic risk score analysis of 37 TGCT susceptibility single-nucleotide polymorphisms in 236 familial and 3931 sporadic TGCT cases, and 12 ...
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The relationship between common genetic markers of breast cancer risk and chemotherapy-induced toxicity: A case-control study
... cancer polygenic risk score was created from the 94 breast cancer risk variants, all of which were genotyped or successfully imputed in ...between polygenic risk score and ...
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Are genetic risk factors for psychosis also associated with dimension specific psychotic experiences in adolescence?
... Findings from twin studies suggest that heritabilities of psychotic disorders are higher than for adolescent psychotic experiences. Estimates of heritability of both schizophrenia and bipolar disorder have been shown to ...
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Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence?
... Findings from twin studies suggest that heritabilities of psychotic disorders are higher than for adolescent psychotic experiences. Estimates of heritability of both schizophrenia and bipolar disorder have been shown to ...
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