polymerase inhibitors
Molecular Characterization and Resistance of Hepatitis B Virus to Polymerase Inhibitors in HIV Co-Infected Patients in Abidjan, Côte d’Ivoire, West Africa
... Significant resistance mutations have been observed in the HBV polymerase gene in some virologically failed patients. This allowed us to estimate the prevalence of genotypic mutation in our study at 33.3%. These ...
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Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus
... (HCV) polymerase, including in the palm and thumb ...the polymerase thumb ...binding polymerase inhibitor had a dramatic impact on the number of replicon colonies able to replicate in the presence of ...
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1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus
... RNA polymerase (NS5B) of hepatitis C virus (HCV) is an unusually attractive target for drug discovery since it contains five distinct drugable ...nonnucleoside inhibitors to be active in at least patients ...
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Mutations Conferring Resistance to Viral DNA Polymerase Inhibitors in Camelpox Virus Give Different Drug-Susceptibility Profiles in Vaccinia Virus
... DNA polymerase (E9L) gene of vaccinia virus ...DNA polymerase inhibitors, including ...DNA polymerase antivirals that were not observed with their CMLV ...
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Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs
... RNA polymerase inhibitors as anti- SARS-CoV-2 drugs targeting its main RNA polymerase, suggesting that investigational and approved nucleoside RNA polymerase inhibitors have potential ...
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QUANTUM MODELLING ANALYSIS OF SOME POTENT INDOLE DERIVATIVES ON NS5B POLYMERASE INHIBITORS
... Hepatitis means inflammation of the liver. It is caused by several mechanisms, including certain infectious agents (Balavignesh et al., 2013). Viral hepatitis is caused by different type of viruses such as hepatitis A, ...
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A selective eradication of human nonhereditary breast cancer cells by phenanthridine derived polyADP ribose polymerase inhibitors
... We examined the effect of PARP inhibitors on MCF-7 and MDA231 human breast cancer cells. Cells were treated with the potent PARP inhibitors, PJ-34, Tiq-A, and Phen (Figure 1) applied only once, 24 hours ...
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Glutaminase and poly(ADP ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL deficient renal cancers
... a 3-day treatment with increasing doses of GLS1 inhibitor BPTES or CB-839. We detected no evidence of either increased apoptosis or senescence within this time frame, despite significant suppres- sion of cell growth ...
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Review Article Potential biomarkers of Poly (ADP-ribose) polymerase inhibitors for cancer therapy
... genes leads to cell death, and each mutation alone is not sufficient to cause cell death. Synthetic lethal is widely used in cancer thera- py to broaden the therapeutic effect for the drug. PARP detects SSB, binds to the ...
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Influence of poly(ADP-ribose)polymerase inhibitors on some parameters of oxidative stress in blood leukocytes of rats with experimental diabetes
... specific inhibitors of poly(ADP-ri- bose)polymerase-1 (PARP-1), in particular nico- tinamide and 1,5-isoqinolinediol on white blood cells of rats with ...PARP-1 inhibitors had no effect on the ...
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2-ARYL-3-(5-PHENYL[1,2,4]TRIAZOLO[4,3-C]QUINAZOLIN-3-YL)-1,3-THIAZOLIDIN-4-ONES AS HCV NS5B RNA POLYMERASE INHIBITORS
... good inhibitors of HCV and develop as potent antiviral agents; and hydrophobic interaction with residue Tyr477 and H-bonding with residues Ser476 and Arg501 may regulate ...
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Current status of poly(ADP-ribose) polymerase inhibitors and future directions
... Abstract: Inhibitors of poly(ADP-ribose) polymerases (PARPs), which play a key role in DNA damage/repair pathways, have been developed as antitumor agents based on the concept of synthetic ...PARP ...
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Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors
... NNI-3 residues that affect genotypic coverage of acyl pyrrol- idine 4 and benzothiadiazine 3. To elucidate the NNI-3 bind- ing site determinants (Fig. 5C and D) that cause the differences of inhibitory activity observed ...
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Naturally occurring resistance mutations to inhibitors of HCV NS5A region and NS5B polymerase in DAA treatment naïve patients
... HCV inhibitors were confirmed in DAA naïve patients with HCV genotypes 1a and 1b ...NS5A inhibitors [17,19,30,31], Q30E/H/K and Y93N/C were not observed, while L31M and Y93H were detected in 2 and 3 ...
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Inhibitors of Respiratory Syncytial Virus Replication Target Cotranscriptional mRNA Guanylylation by Viral RNA-Dependent RNA Polymerase
... RSV polymerase inhibitors increased the appearance of short RNAs ...the inhibitors might pre- vent cotranscriptional capping of viral mRNAs required for full elongation of transcripts (5, ...RSV ...
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Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach
... RNA polymerase domain. Polymerase activity is responsible for viral RNA synthesis by a de novo initiation mechanism and represents an attractive target for antiviral ...new inhibitors of the NS5 ...
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Naturally occurring mutations associated with resistance to HCV NS5B polymerase and NS3 protease inhibitors in treatment naïve patients with chronic hepatitis C
... liver fibrosis) and side effects often resulting in poor tol- erability and treatment contraindication [9]. Recently, new anti-HCV drugs, termed direct-acting antiviral agents (DAAs) have been developed. DAAs target ...
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Taq2000 DNA Polymerase, Part Number Taq2000 DNA Polymerase, Part Number X Taq Polymerase Buffer
... Taq2000 DNA Polymerase Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section ...
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Original Article 3-aminobenzamide, one of poly(ADP-ribose) polymerase-1 inhibitors, rescuesapoptosisin rat models of spinal cord injury
... Poly(ADP-ribose)polymerase-1 (PARP-1) is a key protein participating in DNA repair [1], which is also seen as anuclear enzyme contributing to the chromatin integrity and cell survival [2]. PARP-1 inhibitors ...
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Novel Small-Molecule Inhibitors of RNA Polymerase III
... UK-118005 and ML-60218 exhibit broad-spectrum activity, a subcellular extract was prepared from another yeast, C. albi- cans, by the same protocol as that used for S. cerevisiae. This extract was active in RNA Pol III ...
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