Post-Translational
Proteomics of protein post translational modifications implicated in neurodegeneration
... Kinase dysregulation resulting in protein phosphoryl- ation is widely implicated in neurodegenerative mecha- nisms, where extensive Tau phosphorylation preceding polymerization downstream of a host of kinases is just one ...
13
Sub cellular localization and post translational modifications of the Plasmodium yoelii enolase suggest moonlighting functions
... P. yoelii has a single gene for enolase. Observation of five different isoforms (pI~5.9, 6.1, 6.3, 6.5 and 6.7) suggests that four of these variants arose due to post-translational modifications. Results ...
7
Overview of the Epigenetics and Post translational Modifications (EPI) task of BioNLP Shared Task 2011
... protein post-translational modifications event types with reference to annota- tions originally created for the Protein Information Resource 3 (PIR) (Wu et ...
10
Studies of protein post translational modifications using high resolution tandem mass spectrometry
... protein post-translational modifications (PTMs) due to its unique features of preserving labile modifications and providing more detailed sequence information, which has been used to study protein ...
306
Quantitative protein expression profiling reveals extensive post transcriptional regulation and post translational modifications in schizont stage malaria parasites
... genes post-transcriptional regulation also plays a significant role in the expression of their protein products ...in post- transcriptional regulation during the ...Relieving translational repression ...
18
Developmentally arrested Austrofundulus limnaeus embryos have changes in post translational modifications of histone H3
... H3 post-translational modifications are extensively studied because of their impact on chromatin structure and function and their central role in epigenetic ...
9
PubMed Scale Event Extraction for Post Translational Modifications, Epigenetics and Protein Structural Relations
... and Post-translational Modifications (EPI) and Protein Relations (REL) ...with post- translational modifications from UniProt, epi- genetics from PubMeth, functional domains from InterPro and ...
9
Computer Assisted analysis of subcellular localization signals and post translational modifications of human prion proteins
... Glycosylation is one of the most complex and ubiqui- tous post-translational modifications of proteins in eu- karyotic cells. It is a dynamic enzymatic process in which saccharides are attached to proteins ...
6
HIV latency reversing agents act through Tat post translational modifications
... be post-translationally modified by a variety of cellular factors at different stages of the viral life cycle ...of post-translational modifications on Tat are well characterised, it remains ...
17
Conjugative Post Translational Modifications for Pharmacological Improvement of Therapeutic Proteins [Article Retracted]
... conjugative post-translational modifications used by pharmaceutical industries to improve the pharmacological features of therapeutic proteins for ...
9
Aberrant post translational protein modifications in the pathogenesis of alcohol induced liver injury
... Here, we will discuss the role of this post-translational modification in the regulation of innate immunity in hepatitis C virus (HCV) infection combined with ethanol exposure. About 3% of world population ...
10
A comprehensive resource for integrating and displaying protein post translational modifications
... The proposed server enables both wet-lab biologists and bioinformatics researchers to easily explore the informa- tion about protein post-translational modifications. This study not only accumulates the ...
9
The post-translational modification of the Clostridium difficile flagellin affects motility, cell surface properties and virulence
... is post-translationally modified with an O-linked oligosaccharide at serine and/or threonine resi- dues on the highly variable, surface-exposed domains of the protein (Logan, ...these ...
18
Post-translational modification-regulated leukocyte adhesion and migration
... Leukocytes undergo frequent phenotypic changes and rapidly infiltrate peripheral and lymphoid tissues in order to carry out immune responses. The recruitment of circulating leukocytes into inflamed tissues depends on ...
14
Post translational modifications of HOX proteins, an underestimated issue
... Post-translational modifications (PTMs) of proteins are plethoric and modify the activity, localisation, stability, molecular interac- tions of virtually all proteins in eukaryotic systems. This includes ...
13
Post translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate
... As part of cartilage homeostasis, cartilage proteins are contin- ually degraded and replaced by the chondrocytes. This matrix turnover happens most rapidly in the vicinity of the cells [13] and is greatly reduced in the ...
9
Post-translational regulation of COX2 activity by FYN in prostate cancer cells
... Increased COX2 expression and function has been linked to the initiation and progression of many human cancers, including prostate cancer [3-9, 44-46]. However, described mechanisms involved in the regulation of COX2 ...
12
Post translational buffering leads to convergent protein expression levels between primates
... Adequate post-translational modifications are required for proper folding to take ...in post-translationally buffered genes ...buffered post-translationally ...in ...
15