Post Translational Regulation
Genomic Methods for Studying the Post-Translational Regulation of Transcription Factors
... the Post-Translational Regulation of Transcription Factors Abstract The spatiotemporal coordination of gene expression is a fundamental process in cellular ...regulated post- translationally ...
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Post-translational regulation of COX2 activity by FYN in prostate cancer cells
... ABSTRACT While increased COX2 expression and prostaglandin levels are elevated in human cancers, the mechanisms of COX2 regulation at the post-translational level are unknown. Initial observation ...
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Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells.
... Fig. 2. Genome-scale metabolic modelling of UOK262 cell lines. A) Diagram depicting the different constraints used in Recon 2.2 to obtain the condition-specific, UOK262 and UOK262pFH, metabolic models. B) Biomass yield per ...
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Post-translational Regulation of Plant Fatty Acid Desaturases as Expressed in Saccharomyces cerevisiae
... Bryan (2004) observed differences in BF3 and TF3 steady-state accumulation and half- life when expressed in yeast grown at 30°C, and attributed this effect to post-translational regulation. Likewise, ...
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Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation
... gradual post-translational regulation of the BiP chaperone cycle and its chaperone activity by subtle local perturbations at SBD allosteric ...
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Post-Translational Regulation of FAS-Mediated PPARα Activation
... (PPAR) ␣ is a nuclear receptor that coordinates liver metab- olism during fasting. Fatty acid synthase (FAS) is an enzyme that stores excess calories as fat during feeding, but it also activates hepatic PPAR ␣ by ...
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Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulation
... basal regulation at the transcriptional, post-transcriptional and post-translational ...conditional regulation that underlies decision-making in higher eukaryotic biological ...
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Post-translational regulation of redox-sensitive glutamylcysteine ligase (GCL) - revisited
... Understanding cellular regulatory mechanisms, especially regarding the stress responses needs close attention. Recent studies have focused on glutathione modulation because of its multiple functions, not only related to ...
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Course objective. Protein expression Protein-protein interactions Protein post-translational regulation
... - quantitatively compare samples (sometime it is not possible to obtain equal loading of a gel) Proteins expressed at the same level in many cell lines and tissues, such as β-actin and G[r] ...
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Investigation of the Stability of Yeast rad52 Mutant Proteins Uncovers Post-translational and Transcriptional Regulation of Rad52p
... We investigated the stability of the Saccharomyces cerevisiae Rad52 protein to learn how a cell controls its quantity and longevity. We measured the cellular levels of wild-type and mutant forms of Rad52p when expressed ...
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Regulation of pannexin channels by post-translational modifications
... tight regulation of channel opening is necessary to modulate their function in ...vivo. Post- translational modifications have been postulated as some of the regulating mechanisms for Panx1, while ...
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Surf the Post-translational Modification Network of p53 Regulation
... p53 regulation have been proposed for decades, none of them is ...individual post-translational modifications, further explorations indicate a new layer of p53 coordination through the interplay of ...
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Post-translational Modifications are Required for Circadian Clock Regulation in Vertebrates
... as post-translational modification, regulates several aspects of these cellular clock components, including their stability, subcellular localization, transcriptional activity, and interaction with other ...
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A post-translational mechanism of PD-L1 regulation in glioblastoma multiforme
... 36 4. RESULTS Expression of FKBP51s and PD-L1 in glioma cell lines and tumor sections I semiquantitatively measured the basal expression of FKBP51 isoforms in glioma cell lines (D54 and U251) and primary glioma cell ...
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Mechanistic studies on the regulation of Ran-function by post-translational lysine-acetylation
... 4.3 General implications for the investigation of protein acetylation Besides the Ran-related gain of knowledge/information described and discussed above, several general conclusions can be drawn from this study. First ...
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Post-translational lysine-acetylation of Ran and its regulation by Sirtuin deacetylases
... versa, translational pausing due to the incorporation of AcK may be particularly detrimental to the folding of certain structural elements in a recombinantly produced ...
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Functions and regulation of Hdmx and post-translational modifications in drug sensitivity and cancer.
... Upon DNA damage, p53 is activated, resulting in either cell cycle arrest, to enable the repair of damaged DNA, or apoptosis, when the damage is not repairable. RNF4 can be associated in several ways with the DNA damage ...
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Deciphering the Gene Expression Control in Epigenetic, Post-transcriptional and Translational Regulation
... As aforementioned, this thesis includes three major projects that are related to epigenetic, post- transcriptional, and translational regulation of gene expression. The first project is “DNA ...
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Regulation of liver mitochondrial metabolism during hibernation by post-translational modification
... the regulation of mitochondrial phosphatases is not well understood, it is difficult to speculate how mitochondrial proteins may have been dephosphorylated in the permeabilized tissue from torpid ...
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Camkii Post Translational Modification
... camkii post translational modification may be acutely regulates presynaptic neurotransmitter is measured ...camkii post translational modification may show normal learning trait is that a good ...
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