Postsynaptic density
Postsynaptic density protein 95-regulated NR2B tyrosine phosphorylation and interactions of Fyn with NR2B in levodopa-induced dyskinesia rat models
... function. Postsynaptic density protein 95 (PSD-95), one of the synapse- associated proteins, regulates interactions between receptor and downstream-signaling ...
8
Supramolecular organization of NMDA receptors and the postsynaptic density
... The postsynaptic density (PSD) of all vertebrate species share a highly complex proteome with 1000 conserved proteins that function as sophisticated molecular computational ...
9
Stimulation induces gradual increases in the thickness and curvature of postsynaptic density of hippocampal CA1 neurons in slice cultures
... The postsynaptic density (PSD) appears as dark ma- terial ~ 30 nm thick under the postsynaptic membrane in glutamatergic excitatory synapses of mammalian central nervous system by electron microscopy ...
10
Zinc transporter-1 concentrates at the postsynaptic density of hippocampal synapses
... subnanomolar range, but Zn 2+ transients in neurons have been reported following strong depolarization or oxidation [4]. Accumulation of cytosolic Zn 2+ is common in degen- erating neurons in models of epilepsy, ischemia ...
7
The distinct binding properties between avian/human influenza A virus NS1 and Postsynaptic density protein 95 (PSD 95), and inhibition of nitric oxide production
... Postsynaptic density protein 95 (PSD-95) is a major scaffolding molecule localised at the postsynaptic density (PSD) of excitatory glutamatergic synapses and is mainly expressed in neurons of ...
7
Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder
... The postsynaptic density (PSD) contains a complex set of proteins of known relevance to neuropsychiatric disorders such as schizophrenia and bipolar ...
9
Postsynaptic density protein 95 (PSD-95) is transported by KIF5 to dendritic regions
... In excitatory neurons, neuronal excitability changes syn- aptic function [1–5] by regulating expression level of syn- aptic scaffold proteins such as postsynaptic density protein 95 (PSD-95)—a member of the ...
12
Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice
... The targeting vector for the generation of 1d2d-PSD-95 KI mice was constructed by amplifying a 5’ homology arm (~4.0 kb, the region from exon 2 to exon 5) and a 3’ homology arm (~5.1 kb, region from intron 8 to exon 12) ...
19
Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer’s disease: a preclinical study in rTg4510 mice
... blot analysis of gliosomes prepared from the forebrain of treated mice showed a dose-dependent increase of EAAT2 with maximal induction observed at doses of 10, 20, and 40 mg/kg (Fig. 2a). We then tested the dose of 10 ...
19
Postsynaptic densities fragment into subcomplexes upon sonication
... Postsynaptic density (PSD) fractions were isolated from rat forebrain and ...electron density similar to PSDs that appeared to be fragments of ...
7
BDNF increases synapse density in dendrites of developing tectal neurons in vivo
... the postsynaptic density protein PSD95 tagged with GFP (PSD95-GFP) was used to visualize dendritic arbor morphology and postsynaptic specializations simultaneously in vivo ...with postsynaptic ...
11
Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice
... BDNF signaling through postsynaptic TrkB re- ceptors is essential for the insertion of AMPARs (AMPA-type receptors) for postsynaptic density and the development of mature synapses [ 61 ][r] ...
19
Imaging synaptic plasticity
... the postsynaptic density [46,51], even the small proportion of fusion events that occur within the spine are likely to be excluded from the synapse ...
10
Pre- and postsynaptic effects of brimonidine on isolated rabbit iris dilator muscles
... These results taken together suggest that brimonidine in physiological concentrations mainly activates presynaptic α 2 -adrenoceptors and causes a small amount of pupil miosis without affecting postsynaptic α 1 ...
5
The vertebrate neuronal gamma aminobutyric acid (GABAa) receptor and its modulation: a patch clamp study
... the postsynaptic membrane of neurones in the rat medial amygdala has been shown (Nabekura, Oomura, Minami, Mizuno and Fukado, 1986), Using intracellular recording, these workers described a brief hyperpolarization ...
348
Role of nucleus accumbens glutamatergic plasticity in drug addiction
... decreases postsynaptic depolarization during ...blocks postsynaptic glutamatergic receptors NMDA and GRM5, reducing depolarization in the course of ...
14
Postsynaptic actions of excitatory amino acids investigated with flash photolysis
... In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted.. Copyright of the Dissertation is held by the Au[r] ...
181
Target recognition at the tips of postsynaptic filopodia: accumulation and function of Capricious
... and postsynaptic muscles might occur at the tips of myopodia rather than at the muscle fiber ...and postsynaptic cells occurs and how these initial contacts are stabilized to form the synaptic sites have ...
9
Combined pre- and postsynaptic action of IgG antibodies in Miller Fisher syndrome
... Effect of convalescent serum on quantal content and qEPSC. To further examine the pathogenic relevance of the observed blocking effects, sera from the acute phase of disease and sera obtained after full recovery were ...
9
Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes
... The genetic requirements for supercomplex subtypes could specify assembly anatomically within particular brain regions. To explore whether supercomplexes reside in particular synapses, we used an immunohistochemical ...
8