Posttranscriptional regulation through transcript stability and
Tribbles 1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα
... Variants near the gene TRIB1 are significantly associated with several plasma lipid traits, circulating liver enzymes, and the development of coronary artery disease in humans; however, it is not clear how its protein ...
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Regulation of Caenorhabditis elegans vitellogenesis by DAF-2/IIS through separable transcriptional and posttranscriptional mechanisms
... Figure 1 Regulation of vit-2 mRNA and yolk protein levels in young adult wildtype C. elegans hermaphrodites. A) Quantitation of vit-2 mRNA in wildtype adult hermaphrodites, relative to act-1, normalized to day 1 ...
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MicroRNA-328 enhances cellular motility through posttranscriptional regulation of PTPRJ in human hepatocellular carcinoma
... on cell migration and invasion of both SMMC-7721 and BEL-7402 cells (Figure 4B). Discussion In recent years, the deregulated expression of several miRNAs has been observed in HCC tissues. However, the molecular ...
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Cross-Regulation between Bacteria and Phages at a Posttranscriptional Level.
... “sponge RNAs” that base pair with and block the activities of the target sRNA. Prophage examples of this type of sponge RNAs have now also been found through studies of Hfq- binding sRNAs in EHEC (67). In this ...
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Posttranscriptional regulation of hepatitis B virus replication by the precore protein.
... precore transcript (HBeAg is absent in supernatant derived from trans- fected cells) due to the positioning of the transcription initia- tion site downstream from the CMV IE ...
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Posttranscriptional Gene Regulation: From Global Models to Functional Mechanisms
... in regulation of aging and cell senescence, and the hypothesized ancestral role for Pum proteins in stem cell self-renewal, exploration of the regulatory dynamics of SIRT1, as mediated by Pum1 protein, in an aging ...
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Colorectal cancer: from the genetic model to posttranscriptional regulation by noncoding RNAs
... inactive-specific transcript, related to X-chromosome silenc- ing) and HOTAIR (HOX Transcript Antisense Intergenic RNA) interact with chromatin remodeling complexes to induce changes in chromatin packaging, ...
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Overexpression of miR-1 in the heart attenuates hippocampal synaptic vesicle exocytosis by the posttranscriptional regulation of SNAP-25 through the transportation of exosomes
... travel through blood exosomes, then this molecule may reach other brain areas, such as the frontal cortex and even the whole brain, most likely downregulating ...
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RNA binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism
... ZFP36L1 can bind RNA directly but does not have the capabil- ity of degrading mRNAs by itself. Rather, ZFP36L1 binds mRNA targets in a sequence-specific fashion and then recruits additional proteins, including ...
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MicroRNA regulation in the Immune Response: Intercellular transfer at the Immune Synapse and posttranscriptional modifications
... recirculate through the lymphoid organs, tissue and skin and in case of reappearance of their specific antigen will respond rapidly and generate new effector ...
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Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology
... A specific decrease in SRSF1 protein levels was observed in SRPK1-depleted or SRPIN340-treated colorectal cells, without changes in the corresponding SRSF1 mRNA. This suggests that cytoplasmic SRSF1 localization leads to ...
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The role of protein degradation in maintaining genome stability through regulation of origin licensing
... Cdc6. Through collaboration with Bob Duronio and his graduate student Hyun Lee we show that this phenomenon is conserved in both human and Drosophila cells with respect to Cdt1 regulation, and perturbations ...
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Posttranscriptional and transcriptional regulation of endothelial nitric-oxide synthase during hypoxia: the role of microRNAs
... and posttranscriptional molecular mechanisms that belong to both proapoptotic and survival ...of posttranscriptional modulation by microRNAs (miRNAs), this class of short noncoding RNAs contribute another ...
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Posttranscriptional Gene Regulation of T Follicular Helper Cells by RNA-Binding Proteins and microRNAs
... the regulation of T cell fate decisions ( 14 , 18 – 22 ...targets through similar stem- loop structures ( 16 , 21 , 33 , 34 ) that are present in an overlapping set of target mRNAs with pro-inflammatory ...
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Posttranscriptional Regulation of the Yersinia pestis Cyclic AMP Receptor Protein Crp and Impact on Virulence
... the posttranscriptional regulation of Crp in ...regulated through Hfq that are needed during plague ...the posttranscriptional regulation of Crp, and the host signals that ...and ...
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Posttranscriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors
... HuR has been independently identified by multiple studies as a PAR-binding protein in response to DNA damage (under H 2 O 2 or methyl methane sulfonate stimulation), indicating PARylation as a means of coordinating ...
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The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels
... the regulation of V max ...hierarchical regulation can be dissected in terms of the relative contributions of these different regulatory ...advanced regulation analysis is applied to glyco- lysis in ...
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Regulation of the state debt stability
... Thus, considering each rule separately, the most effective from the point of view of implementing countercyclical fiscal policy is the application of a modified rule of balanced budget on the basis of structural ...
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Different regulation of limb development by p63 transcript variants
... * [email protected] Abstract The apical ectodermal ridge (AER), located at the distal end of each limb bud, is a key sig- naling center which controls outgrowth and patterning of the proximal-distal axis of the ...
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Expression of ras oncogenes in cultured human cells alters the transcriptional and posttranscriptional regulation of cytokine genes
... transcription only for the IL-1 gene. Analysis of mRNA half-life demonstrated a marked increase in the stability of numerous cytokine transcripts, including G-CSF, GM-CSF, IL-1, and IL-6. The addition of anti-IL-1 ...
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