Posttranslational modification (PTM)
Impact of the Adenoviral E4 Orf3 Protein on the Activity and Posttranslational Modification of p53
... of PTM on the properties and activi- ties of p53, a crucial regulator of cell survival, proliferation, and ...the modification states of particular resi- dues, that is, the absence or presence of particular ...
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Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity
... HNE modification target ...via posttranslational modification (PTM) and mutation trigger the formation of aggregated, toxic aSyn species, which interfere with cellular ...
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Posttranslational Modification and Cell Type-Specific Degradation of Varicella-Zoster Virus ORF29p
... the posttranslational modification of ORF29p to attempt to unravel the basis for the subcellular targeting of this ...ORF29p modification and degrada- tion occur in 293T, U373MG, and MeWo cells; ...
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Posttranslational Modification of Vesicular Stomatitis Virus Glycoprotein, but Not JNK Inhibition, Is the Antiviral Mechanism of SP600125
... tive regulation of the IFN-␣ response (43). In many HCC cell lines, the innate immunity response to pathogens is compro- mised, especially due to multiple defects in the type I IFN system (38). The reestablishment of a ...
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Posttranslational Modification of α-Dystroglycan, the Cellular Receptor for Arenaviruses, by the Glycosyltransferase LARGE Is Critical for Virus Binding
... of posttranslational modification adds another level of com- plexity to the virus-receptor interaction and the virus-host in- ...of modification that is crucial for the biological function of the ...
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EF P Posttranslational Modification Has Variable Impact on Polyproline Translation in Bacillus subtilis
... EF-P is modified through multistep assembly that is reminiscent of FAB. In order to efficiently stimulate translation of polyproline motifs, EF-P requires PTM of a con- served residue. In Gram-negative bacteria and ...
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Dynamic Characterization of Protein and Posttranslational Modification Levels in Mycobacterial Cholesterol Catabolism
... ABSTRACT Cholesterol of the host macrophage membrane is vital for mycobacte- rial infection, replication, and persistence. During chronic infection within host lung tissues, cholesterol facilitates the phagocytosis of ...
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Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
... N-acetylglucosamine modification and decreases O-linked phosphorylation of the transcription factor Sp1, the effect of hyperglycemia and the hexosamine pathway on eNOS was ...N-acetylglucosamine ...
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Posttranslational modification and subcellular localization of the p12 capsid protein of herpes simplex virus type 1.
... In contrast, the TrpE-UL35 antiserum reacted with two proteins, designated pl2a and pl2b, which were present in lysates of HSV-infected cells radiolabeled with either [35S]methionine or [r] ...
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Posttranslational Modification of HOIP Blocks Toll Like Receptor 4 Mediated Linear Ubiquitin Chain Formation
... alter the intrinsic enzymatic activity of HOIP (see Fig. S1F in the supplemental material). These experiments collectively demon- strate that HOIP is ubiquitinated at the K1056 by multiple types of ubiquitin chains and ...
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HIV infection induced posttranslational modification of T cell signaling molecules associated with disease progression
... lymphocytes of HIV-infected individuals. Total amounts of protein tyrosine kinases (PTKs) Lck, Fyn, and ZAP-70 and the zeta chain of the TCR were found significantly decreased in T cells of symptomatic/AIDS patients as ...
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The Complexity of the IGF1 Gene Splicing, Posttranslational Modification and Bioactivity
... The insulinlike growth factor-I (IGF-I) is an important factor which regulates a variety of cellular responses in multiple biological systems. The IGF1 gene comprises a highly conserved sequence and contains six exons, ...
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Posttranslational modification and intracellular transport of mumps virus glycoproteins.
... Mumps virus apparently differs from Newcastle disease virus in that cleavage of F and formation of HN oligomers are posttranslational modifications which occur after the appearance of th[r] ...
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A Dynein Light Chain 1 Binding Motif in Rabies Virus Polymerase L Protein Plays a Role in Microtubule Reorganization and Viral Primary Transcription
... and posttranslational modification, suggesting a model in which MT manipulation by L contributes to efficient intracellular transport of virus components and thus may serve as an important step in virus ...
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A novel human immunodeficiency virus type 1 protein, tev, shares sequences with tat, env, and rev proteins.
... To determine whether either p28tev or p22 bears this posttranslational modification, HeLa cells transfected with fB, mutant 107, or a mixture of pL3tat and pL3crev were labeled with 32Pi[r] ...
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ORC, MCM, and Histone Hyperacetylation at the Kaposi's Sarcoma-Associated Herpesvirus Latent Replication Origin
... Posttranslational modification of histone tails may distinguish chromosomal boundaries and establish higher-order 12566 Downloaded from http://jvi.asm.org/ on November 8, 2019 by guest T[r] ...
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Experimental detection of short regulatory motifs in eukaryotic proteins: tips for good practice as well as for bad
... ELM: Eukaryotic linear motif resource; IDP: Intrinsically disordered polypeptide; PTM: Post-translational modification; SLiM: Short linear motif; NES: Nuclear export signal; SH2: Src Hom[r] ...
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Conjugative Post Translational Modifications for Pharmacological Improvement of Therapeutic Proteins [Article Retracted]
... PEGylation is a PTM strategy that has been developed to overcome pharmacokinetic (PK) and pharmacodynamic (PD) limitations of therapeutic proteins. It consists of the attachment of polyethylene glycol (PEG) chains ...
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PTM-ssMP: A Web Server for Predicting Different Types of Post-translational Modification Sites Using Novel Site-specific Modification Profile
... each PTM type [49, ...nine PTM types investigated in this study, and experimentally determined PTM sites with proximal PTM information are extracted as positive samples for each PTM ...
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A leucine triplet repeat sequence (LXX)4 in p6gag is important for Vpr incorporation into human immunodeficiency virus type 1 particles.
... of pTM-RSV-GAG and RSV-HIV chimeras (pTM-RHE and pTM-RHP6) are illustrated at the bottom and are aligned to the relative positions in RSV and HIV-1 Gag ...sequences. pTM-RSV-GAG includes RSV ...
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