Potential Implications for Cancer
Potential implications of GRP58 expression and susceptibility of cervical cancer to cisplatin and thymoquinone-based therapy
... Conclusion In summary, the GRP58 expression level depending on the type of cell and type of drug. In this study, there was a correla- tion between expression of GRP58 protein and the cytotoxicity of cisplatin in HeLa and ...
13
Effect of phytoestrogens on breast and prostate cancer cell lines – potential implications for bone metastasis
... endometrial cancer in women and exacerbate autoimmune diseases, whereas the loss of oestrogens during menopause has been correlated with osteoporosis, coronary heart disease, depression and ...
191
Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy
... demonstrating a higher V max , (ii) CYP1A1 was essentially inactive in the formation of DM-2 with CYP3A4 exhibiting significant activity (iii) both enzymes generated OH-1, but CYP1A1 had both a lower K M and higher V max ...
34
Mutant NRAS Q61 shares signaling similarities across various cancer types – potential implications for future therapies
... We were able to demonstrate that the combination of a MEKi and a PI3K/mTORi can reduce cell viability in NRAS mutant cancer cell lines other than melanoma. The calculated combination index showed a clear ...
9
Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy
... definitive proof of MUC4 overexpression as an early event in PC. In the present study, we observed that Muc4 mRNA and protein levels increased progressively from 10 weeks of age, which is when we observed the appearance ...
12
Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices.
... breast cancer cell lines demonstrated that the cell line which was most sensitive to cisplatin expressed low levels of cyclin D1, and that cell lines transfected with cyclin D1 siRNAs exhibited enhanced ...
20
Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices.
... Supplement 3. 201 probe sets differentially expressed between HPV – oropharyngeal cancer and HPV – oropharyngeal control. Probe Set ID Gene Symbol t-stat p-value 211070_x_at DBI -13.333 < 0.001 209389_x_at DBI ...
18
Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications
... Acetate, together with other short chain fatty acids has been implicated in colorectal cancer (CRC) prevention/therapy. Acetate was shown to induce apoptosis in CRC cells. The precise mechanism underlying acetate ...
15
The MHC Class-I Transactivator NLRC5: Implications to Cancer Immunology and Potential Applications to Cancer Immunotherapy
... future. Cancer neoantigens discovered through these approaches can be used to induce a TSA-specific immune response, expand TSA- specific CTLs for ACT or generate TSA-specific CAR-T ...expression. Cancer ...
36
Role of Cholinergic Receptors in Colorectal Cancer: Potential Therapeutic Implications of Vagus Nerve Stimulation?
... 4.5. Potential Therapeutic Use of VNS To date different approaches have been done targeting nAChR in cancer therapy in particular tobacco-related ...colon cancer cell ...
16
The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications
... of cancer-relevant CRL4 ligases, there are still many controversies to be ...to cancer need to be proved whether they are the substrates of ...clinical implications in ...
13
Identification of a novel prostate cancer biomarker, caveolin-1: Implications and potential clinical benefit
... prostate cancer progression reflects the success of this ...prostate cancer, with higher levels evident in metastatic versus primary ...prostate cancer from normal controls, and preoperative Cav-1 ...
12
Potential therapeutic implications of IL-6/IL-6R/gp130- targeting agents in breast cancer
... BREAST CANCER Numerous IL-6/IL-6R/gp130 blockers have been described and developed as anti-inflammatory drugs, and some of them have also been studied as anticancer ...breast cancer are limited despite the ...
14
Membrane potential and cancer progression
... CLINICAL IMPLICATIONS Given that the fluctuation of V m can functionally regulate tumori- genesis, differentiation, and promote cancer progression, it may serve as a potential marker for tumor ...
11
Prostate cancer. Clinical implications of obesity
... prostate cancer development, its clinical implications and effect on treatment ...with potential biochemical mechanisms related to obesity, which may act on prostate cancer development or ...
171
Breast cancer stem cells: implications for therapy of breast cancer
... proliferative potential of cancer stem cells has been examined in vitro, in particular for stem cell-like neural precursors of human glioblastoma, and has been charac- terised as capable of exponential ...
14
The Identifications and Clinical Implications of Cancer Stem Cells in Colorectal Cancer
... colorectal cancer expressing high Lgr-5 had 10-fold higher risk for cancer relapse than patients with low expression of Lgr-5 ...the potential of CSC as they showed high number of spheroid formation ...
42
Cancer stem cells: therapeutic implications and perspectives in cancer therapy
... expressing cancer types including metastatic ...gastric cancer cells in vitro. It suggests that CD133 is a potential therapeutic target for antibody-drug conjugates, and anti-CD133 antibody-drug ...
11
Identification of three subtypes of triple negative breast cancer with potential therapeutic implications
... and C3 compared to C1. Genes highly expressed in C2 vs C3 were notably linked to central nervous system develop- ment process, here considered as neurogenesis, extracellu- lar matrix disassembly, and collagen metabolic ...
14
Biosimilars: potential implications for clinicians
... is potential for reduction in health care costs of associated bio- pharmaceuticals and the creation of a more affordable biologic ...immunogenicity potential, a required reported component for US FDA ...
8