PPAR-?
Original Article Prognostic role of PPAR-γ and PTEN in the renal cell carcinoma
... tive PPAR-γ expressions in normal kidney tissu- es ...that PPAR-γ is positively related to the tumor development ...higher PPAR-γ expressions in patients at stage III+IV and with lymph node ...
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PPAR[gamma]-independent mechanisms of Src kinase activation and EGFR transactivation in response to thiazolidinediones
... of PPAR -dependent target genes and allows association of the active PPAR/ RXR transcription complex (Tugwood et ...of PPAR/ RXR binding specificity (Figure ...
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PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population
... of PPAR γ include the fat-specific ap2 gene, LPL, fatty acid transport, fatty acid binding protein, ABC-A1 ...of PPAR γ polymorphisms is rs1805192 ...
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Peroxisome Proliferators Activated Receptor (PPAR) agonists activate hepatitis B virus replication in vivo
... used PPAR agonists including two fibrates and one thiazolidinedione targeting on three kinds of PPARs were selected in this ...these PPAR agonists to HBV replication, a baseline HBV replication level in HBV ...
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In silico Studies on Plant Derived Rutin as Potent Agonist of Peroxisome Proliferator-activated Receptor Gamma (PPAR
... Aims: Peroxisome proliferator-activated receptor gamma (PPARγ) agonists are beneficial in the management of diabetes by increasing insulin sensitivity and inhibiting hepatic gluconeogenesis. The aim of the present study ...
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Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease
... However, we have also observed that only high doses of neurotoxins can induce DA neuron death in neuron- enriched primary mesencephalic cultures [11,13,83-85]. This was confirmed in a recent study using a DA cell line ...
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24-Methylenecycloartanyl Ferulate Induces PPAR-γ2 Mediated Regulation of Angiogenesis-Related Genes and Inhibits Akt/mTOR Signaling
... LIF, PPAR-γ2 and EGR1 genes) and six pro-angiogenesis-related genes that were downregulated (HoxA7, L1Cam, MMP11, RHOT1, VEGF, and Pbx1 ...NPPB, PPAR-γ2, and EGR1) and oncogenic genes ...
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Anti-fibrogenic effect of PPAR-γ agonists in human intestinal myofibroblasts
... of PPAR-γ agonists can be mediated through both PPAR-γ-dependent [26, 32, 37, 52] and PPAR-γ- independent pathways [23, 28, 31, ...was PPAR-γ-dependent because the PPAR-γ antagon- ist ...
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Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma
... While PPAR-α expression was weak in the gray matter, a high expression was observed in some cells in the white matter, especially in ...of PPAR-α in astrocytes suggests that this isoform mod- ulates central ...
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Peroxisome proliferator activated receptor gene expression in human tissues Effects of obesity, weight loss, and regulation by insulin and glucocorticoids
... than PPAR g1 (Werman, ...in PPAR g2 mRNA is secondary to obesity or increased food in- take, or is due to an independent defect leading to its up-regu- ...on PPAR g2 mRNA expression, we observed a ...
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Renal tubular epithelium-targeted peroxisome proliferator- activated receptor-γ maintains the epithelial phenotype and antagonizes renal fibrogenesis
... of PPAR-γ on renal fibrosis, the mice were randomized into the following four groups (n = 6 in each group): (1) sham operated mice of WT mice, (2) UUO model of WT mice, (3) sham operated PT-PPAR-γ-CKO mice, ...
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The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers
... imens raised questions about the anti-neoplastic activity of the receptor in vivo. For example, PPARγ was found highly expressed in ovarian carcinoma [39] and its overex- pression in pancreatic carcinoma was associated ...
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Toll like receptor 4 (TLR4) down regulates microRNA 107 increasing macrophage adhesion via cyclin dependent kinase 6
... and PPAR-α expression in response to LPS over ...of PPAR-α was measured by RT-PCR in the same manner as ...for PPAR-α and β-actin, ...and PPAR-α were measured by ...and PPAR-α) and ...
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Peroxisome Proliferator-Activated Receptor γ 2 Modulates Late-Pregnancy Homeostatic Metabolic Adaptations
... Using a model of late pregnancy in PPAR γ 2 knockout (KO) mice, we found that deletion of PPAR γ 2 exacerbated IR in association with lower serum adiponectin levels, increased body wei[r] ...
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Assessment of Drugs Toxicity and Associated Biomarker Genes Using Hierarchical Clustering
... (Euclidean) and HC (ward) methods for PPAR signaling pathway dataset at 24 hour time point.. combination of distance (Euclidean) and HC (ward) methods for PPAR signaling pathway dataset [r] ...
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Targeting 3-phosphoinositide-dependent protein kinase 1 by N-acetyl-cysteine through activation of peroxisome proliferators activated receptor alpha in human lung cancer cells, the role of p53 and p65
... of PPAR α ; Blockade of PPAR α abrogates the inhibitory effect of NAC on PDK1 expression and cell ...against PPAR α . The bar graphs represent the mean ± SD of PPAR α /GAPDH of three ...
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Dohaekseunggi tang extract inhibits obesity, hyperlipidemia, and hypertension in high fat diet induced obese mice
... as PPAR-γ, aP2, and leptin [22]. PPAR-γ is a transcription factor promin- ently expressed in adipose tissue, and it activates adipocyte differentiation ...of PPAR-γ ...of PPAR-γ then the ...
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PPARδ regulates satellite cell proliferation and skeletal muscle regeneration
... ablate PPAR δ in myogenic progenitor cells. Although Ppar δ -cKO mice were born normally and initially displayed no difference in body weight, muscle size or muscle composition, they later developed ...
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<p>Effects Of PPARγ2 Pro12Ala Variant On Adipocyte Phenotype Dependent Of DHA</p>
... of PPAR γ 2 gene in preadipocytes resulted in increased lipid droplet accumulation and adipocyte differentiation, and exhibited anti-in fl ammatory effects by reducing proin fl am- matory cytokine (TNF- α and ...
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IDENTIFICATION OF NOVEL PPARγ MODULATORS / PARTIAL AGONISTS THROUGH VIRTUAL SCREENING WORKFLOW
... Pharmacophore generation (Discovery studio 4.0v., San Diego, CA, USA; http://www.accelrys.com) was used for the analysis of the PPAR-gamma structures are Rosiglitazone-2PRG, Pioglitazone-2XKW, Troglitazone-2VN0. ...
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