PPAR alpha
![Role of PPAR[alpha] in coronary heart disease and cardiac hypertrophy](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
Role of PPAR[alpha] in coronary heart disease and cardiac hypertrophy
... The PPAR genotype association with the fall in fibrinogen levels in response to bezafibrate treatment was seen statistically through an interaction with baseline fibrinogen levels and therefore maybe working ...
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<em>PPARα</em> gene variants as predicted performance-enhancing polymorphisms in professional Italian soccer players
... that PPAR α intron 7 G/C polymorphism was associated with physical performance in Russian athletes, and this may be explained, in part, by the association between PPARα genotype and muscle-fiber-type ...the ...
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PROBABLE ROLE OF PPAR ALPHA IN ATTENUATED CARDIOPROTECTIVE EFFECT OF ISCHEMIC PRECONDITIONING IN HYPERLIPIDEMIC RAT HEARTS
... of PPAR-α has not affected the cardioprotective effect of IPC in normal rat hearts, but its treatment markedly restored the cardioprotective potential of IPC in hyperlipidemic rat ...
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The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats
... We show that pioglitazone causes negative skeletal effects similar to those seen for rosiglitazone. Plasma levels of osteocalcin were significantly reduced in the PIO OVX group compared to all the other groups, sug- ...
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shRNA-mediated PPAR alpha knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth
... recurrence. PPAR is a transcription factor involved in the control of lipid, carbohydrate and amino acid ...that PPAR gene and protein expression is increased in glioblastoma and has independent ...
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Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone
... into PPAR α (pdb 1I7G), PPAR γ (pdb 2PRG), and PPAR δ (pdb 2ZNP), respectively, screening out 23 compounds with higher docking scores and better binding poses than the original ...with PPAR α ...
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Evolution in pharmacologic thinking around the natural analgesic palmitoylethanolamide: from nonspecific resistance to PPAR-α agonist and effective nutraceutical
... Soon after the breakthrough paper of Levi-Montalcini, the mast cell indeed emerged as an important target for the anti- inflammatory activity of PEA. In the period 1993–2011, at least 25 papers were published on the ...
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<em>Cytochrome</em> <em>P450 3A4*22</em>, <em>PPAR-α</em>, and <em>ARNT</em> polymorphisms and clopidogrel response
... of PPAR-α and ARNT genes were associated with increased platelet reactivity, in patients treated with ...CYP4A4*22, PPAR-α, and ARNT variants which have been demonstrated to be associated with CYP3A4 ...
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Do PPARGC1A and PPAR alpha polymorphisms influence sprint or endurance phenotypes?
... Peroxisome proliferator-activated receptor gamma coactivator1α (PPARGC1A) is a transcription coactivator that probably plays a role in a wide variety of biological responses, including mitochondrial biogenesis (Liang ...
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In silico Studies on Plant Derived Rutin as Potent Agonist of Peroxisome Proliferator-activated Receptor Gamma (PPAR
... Several studies have identified peroxisome proliferator-activated receptor as key regulators of glucose and lipid metabolism [4,5], because they act as transcription factors activating protein synthesis in a wide variety ...
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Expression and relationship of PPARγ and COX-2 in Peripheral Blood Mononuclear Cells of Multiple Organ Dysfunction Syndrome Patients
... that PPAR has a wide range of functions, and plays an important role in lipid metabolism, glucose metabolism, cell proliferation, differentiation, apoptosis, wound healing and ...includes PPAR alpha, ...
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Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion
... of PPAR-alpha, lipoperoxides, type 1 (CB1) and type 2 (CB2) cannabinoid receptors, and COX-2, and decreased brain tissue concentrations of docosahexaenoic acid (DHA), one of the major targets of lipid ...
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The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes
... for PPAR γ , which causes the transcription of several genes involved in glucose and lipid metabolism as well as with the pro- duction of inflammatory mediators [17, ...that PPAR γ agonists might be useful ...
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Activation of peroxisome proliferator– activated receptor gamma induces anti-inflammatory properties in the chicken free avian respiratory macrophages
... Results: FARM had eccentric nucleus and plasma membrane ruffled with filopodial extensions. Ultrastructurally, numerous vesicular bodies presumed to be lysosomes were present. FARM treated with troglitazone, a selective ...
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Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease
... that PPAR-g and other PPARs may inhibit NADPH oxidase activity and other signaling pathways involved in AII-induced oxidative stress and inflammation ...the PPAR-g antagonist GW9662, observed in the present ...
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Omega-3 fatty acids regulate gene expression levels differently in subjects carrying the PPARα L162V polymorphism
... of PPAR-V162 isoform was lower than the wild-type isoform; however, at high synthetic ligand levels, the activity of the polymorphic receptor was higher than the wild-type ...
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Carnitine transporter OCTN2 and carnitine uptake in bovine kidney cells is regulated by peroxisome proliferator-activated receptor β/δ
... bovine PPAR β / δ target gene CPT1A in MDBK cells indicating activation of PPAR β / δ ...the PPAR β / δ antagonist completely abolished the stimulatory effect of GW0742 on carnitine ...
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PPAR[gamma]-independent mechanisms of Src kinase activation and EGFR transactivation in response to thiazolidinediones
... Recent work from our lab and others has shown that TZDs, ligands of the nuclear transcription factor PPAR (Lehmann et al., 1995) and used to reverse hyperglycemia in type II diabetes, mediate the activation of ...
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Original Article Prognostic role of PPAR-γ and PTEN in the renal cell carcinoma
... of PPAR-γ expression and PTEN expression to the clinical parameters and prognosis of RCC and explore the relation of PPAR-γ expression and PTEN expression in ...RCC. PPAR-γ exerts a great influence ...
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Peroxisome Proliferators Activated Receptor (PPAR) agonists activate hepatitis B virus replication in vivo
... used PPAR agonists including two fibrates and one thiazolidinedione targeting on three kinds of PPARs were selected in this ...these PPAR agonists to HBV replication, a baseline HBV replication level in HBV ...
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