PPARγ agonist
Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality
... brain. PPARγ agonists can potentially control neuroinflammation through their actions on the activated microglia which can produce, similar to periph- eral macrophages, pro-inflammatory and neurotoxic fac- tors, ...
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The PPARγ agonist pioglitazone prevents TGF-β induced renal fibrosis by repressing EGR-1 and STAT3
... on PPARγ ago- nists having antihypertensive effects, caused by increased endothelial NO levels and inhibition of ANG II ...with PPARγ agonist treatment (rosiglitazone) in wild type mice on regular ...
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Effects of the PPARγ agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus
... a PPARγ-responsive gene (56), and the PPARγ agonist troglitazone has been demonstrated to increase postheparin plasma LPL activity (57) and both preheparin (58) and postheparin (59) LPL mass in ...
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Original Article Effects of PPARγ agonist rosiglitazone on human retinoblastoma cell in vitro and in vivo
... Abstract: The aim of the study was to evaluate the antitumor effects of the PPARγ agonist rosiglitazone on the human retinoblastoma. The cell biological behavior was detected, specifically, the effects of ...
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PPARγ agonist through the terminal differentiation phase is essential for adipogenic differentiation of fetal ovine preadipocytes
... Before differentiation induction, fetal oPADs (passage 3), 3T3-L1 cells (American Type Culture Collection, ATCC, Manassas, VA, USA; within passage 6), and NIH-3T3 (ATCC, Manassas, VA, USA; within passage 6) were cultured ...
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Different skeletal effects of the peroxisome proliferator activated receptor (PPAR)α agonist fenofibrate and the PPARγ agonist pioglitazone
... are PPARγ agonists, currently used for the treatment of insulin resistance and type 2 diabetes melli- tus [8], while fibrates are mainly PPARα agonists that are efficient in lowering elevated triglyceride ...
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The effects of PPARγ agonist rosiglitazone on neointimal hyperplasia in rabbit carotid anastomosis model
... Our results suggest that rosiglitazone may play an atheroprotective role via its beneficial effects on gelati- nases (MMP-2 and −9) throughout inflammatory process particularly in the high cardiovascular risk popu- ...
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Immortalisation of Normal Human Urothelial Cells Compromises Differentiation Capacity
... Figure 7 Effects of long-term hTERT over-expression on molecular differentiation and barrier function of urothelial cell cultures (A) Control virus-transduced (HU-neo) and HU-hTERT cells at the indicated passage number ...
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Original Article Long noncoding RNA SRA1 attenuates hypoxia-induced injury in H9c2 cardiomyocytes through regulating PPARγ/NF-κB signaling pathway
... coactivate PPARγ in mice [13]. The PPARγ agonist pioglitazoneis found to have the ability to relieve severe pulmonary hyper- tension and vascular remodeling and prevent- ing right heart failure in ...
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Peroxisome Proliferator Activated Receptor-gamma P465L Point Mutation in Diabetes and Atherosclerosis
... (PPARγ) agonist Thiazolidinedione drugs which act as insulin ...of PPARγ agonists [2, 3, 4]. PPARγ is a nuclear receptor, and amongst its myriad functions, is necessary for adipocyte ...
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The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells
... (PPARγ) agonist pioglitazone in modulating EAAT2 expression in glioma ...The PPARγ antagonist GW9662 inhibited the effect of pioglitazone on extracellular glutamate levels, indicating PPARγ ...
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Journal of Applied Pharmaceutical Science
... PPARs are involved in the pathophysiology of the various types of diseases. Variety of PPAR-related medicines has been developed and employed clinically all over the world. It is used in multiple effects, including ...
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Original Article Activation of peroxisome proliferator-activated receptor γ improves endothelial dysfunction induced by Porphyromonas gingivalis through the PI3K/Akt, ERK and NFκB pathways
... with PPARγ agonist (15-deoxy- Δ12,14-prostaglandin J 2 , 10 µM) or antagonist (GW9662 10 µM) and assessed for the levels of nitric oxide (NO), endothelial NO synthase (eNOS), inducible NOS (iNOS), protein ...
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Peroxisome proliferator activated receptor γ agonism attenuates endotoxaemia induced muscle protein loss and lactate accumulation in rats
... of PPARγ agonism on muscle protein loss and lactate accumulation during in vivo LPS-induced ...the PPARγ agonist, Rosi, to rodents reduced skeletal muscle cytokine mRNA expression during in vivo ...
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CDX2 driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling
... Reversal of CDX2-induced transcriptional changes by PPARγ agonist treatment. Given that CDX2 is aberrantly expressed in most AML patients and promotes leukemogenesis, interfering with CDX2 or its downstream ...
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Delta 9 tetrahydrocannabinol protects against MPP+ toxicity in SH SY5Y cells by restoring proteins involved in mitochondrial biogenesis
... The PPARγ receptor is able to regulate the expression of a vast variety of target ...the agonist used as they may alter intracellular factors such as the availability of specific co-activators [42], ...
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A Machine Learning Approach for the Discovery of
... structure for most of the full agonist trajectory, whereas in the inverse agonist bound trajectories these 440. residues are in a more disordered conformation[r] ...
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PPARγ and human metabolic disease
... and PPARγ) suggest that these moieties are intimately involved in nutrient sensing and the regulation of carbohydrate and lipid ...while PPARγ is principally involved in the cellular assimilation of lipids ...
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Peroxisome proliferator activated receptor γ haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritis
... inflammatory effect in macrophages derived from mice homozygous for a null mutation in the PPARγ gene, indicating that they can work by a PPAR γ -inde- pendent mechanism (18). PPAR γ expression is dispen- sable ...
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S nitrosoglutathione reductase–dependent PPARγ denitrosylation participates in MSC derived adipogenesis and osteogenesis
... Bone marrow–derived mesenchymal stem cells (MSCs) are multi potent stem cells with the capacity to self renew and differentiate into mesodermal lineages that include adipocytes, osteoblasts, and chondrocytes (1, 2). ...
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