Pre-mRNA alternative splicing
FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing
... the alternative splicing mediated by hnRNPF whereas increased expression of hnRNPF over- comes the repression of alternative splicing by ...modulate pre-mRNA alternative ...
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Palmitate- and C6 ceramide-induced Tnnt3 pre-mRNA alternative splicing occurs in a PP2A dependent manner
... Tnnt3 pre-mRNA alternative ...Tnnt3 alternative splicing was different in myotubes treated with the unsaturated fatty acids oleate and linoleate, compared to those treated with ...in ...
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T cell deficiencies resulting from aberrant pre mRNA alternative splicing caused by a novel splicing silencer hnRNP LL in an ENU mutant mouse strain thunder
... termed pre-mRNA alternative splicing, how does alternative splicing control immune functions? To answer these questions, ENU mutagenesis is a powerful approach to provide ideal ...
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The Function of Pre-mRNA Alternative Splicing in Mammal Spermatogenesis
... Abstract Alternative pre-mRNA splicing plays important roles in co-transcriptional and post-transcriptional regulation of gene expression functioned during many developmental processes, such ...
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Model Systems to Explore CPB2 Pre-mRNA Splicing
... CPB2 pre-mRNA alternative splicing events occurring in various vascular and immune cells via real time RT-PCR ...the alternative splicing pattern of CPB2 by the cell specific ...
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Alternative Splicing of the Drosophila Dscam Pre-mRNA Is Both Temporally and Spatially Regulated
... of alternative splicing. The Dscam gene contains 95 alternative exons that are organized into four clusters of 12, 48, 33, and 2 exons ...Dscam mRNA isoforms can be synthesized, it remains to ...
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m6A potentiates Sxl alternative pre mRNA splicing for robust Drosophila sex determination
... and exon junction reads from control and dIME4 null females below the annotated gene model. 289[r] ...
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Regulation of early and late HIV-1 gene expression by alternative pre-mrna splicing
... a splicing regulatory factor of the SR protein family, U2AF 65 was found to be dispensable for splicing of the chimeric PIPEG pre-mRNA substrate in vitro ...for splicing in almost all ...
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SKIP controls flowering time via the alternative splicing of SEF pre-mRNA in Arabidopsis
... and splicing factor [48, 49]. SKIP specifically regulates the alternative splicing and expression of p21 by interacting with the 3'ss recognition factor U2AF65 and recruiting it to p21 mRNA in ...
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Targeting a pre-mrna structure with bipartite antisense molecules modulates tau alternative splicing
... of alternative pre-mRNA ...other splicing events typically target continuous linear sequences of the ...a pre-mRNA can be targeted by bipartite anti- sense molecules designed to ...
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C6 Pyridinium Ceramide Influences Alternative Pre-mRNA Splicing by Inhibiting Protein Phosphatase-1
... changes alternative splicing of endogenous genes Ceramides have previously been implicated in regulation of splice site selection ...on pre-mRNA processing is not clear, partly because ...
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SmN: Expression and potential role in alternative mRNA splicing
... of alternative splicing pathways result from differential promoter usage or differential ...on pre-mRNA transcripts during their association with the splicing machinery or other Sm ...
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Transcriptome-wide Regulation of Pre-mRNA Splicing and mRNA Localization by Muscleblind Proteins
... RESULTS Identification of Hundreds of Mbnl-Responsive Exons We performed single-end RNA sequencing (RNA-seq) of poly(A) + RNA from brain, heart, and muscle from five 4-month-old Mbnl1 DE3/DE3 mice and age-matched ...
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Studies on mammalian pre-mRNA splicing : connections to transcription and cancer
... 13 the average length of RNA fragments to ~50 nt, the protein of interest is immunoprecipitated under stringent conditions and then digested with proteinase K, leaving RNA that can be amplified and cloned (Ule et al. ...
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Intronic motif pairs cooperate across exons to promote pre mRNA splicing
... The co-occurring pair hypothesis predicts that muta- tions that occur in these motifs should have a higher likelihood of disrupting exon splicing than those that occur in the same motifs when they are alone. ...
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The ASRG database: identification and survey of Arabidopsis thalianagenes involved in pre mRNA splicing
... some splicing-related genes may be ...Several splicing-related genes have been reported to be regulated in this ...of alternative transcripts which use a cryptic 5' splice ...the alternative ...
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Local assembly and pre-mRNA splicing analyses by high-throughput sequencing data
... 117. Hatton AR, Subramaniam V, Lopez AJ: Generation of Alternative< i> Ultrabithorax</i> Isoforms and Stepwise Removal of a Large Intron by Resplicing at Exon–Exon Junctions. Molecular cell 1998, ...
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Development of an in vitro pre-mRNA splicing assay using plant nuclear extract
... on splicing of plant introns in mammalian splicing extracts [45, 46] suggest similar basic mechanisms of intron pro- cessing across eukaryotic systems, but there are also numerous indications of ...
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Signal-dependent splicing of tissue factor pre-mrna modulates the thrombogenecity of human platelets
... TF pre-mRNA splicing involves Cdc2-like kinase (Clk)1, an enzyme not previously known to be pres- ent or operate in ...(SF2)/alternative splicing factor (ASF) phosphorylation, TF ...
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RNA binding protein RBM20 represses splicing to orchestrate cardiac pre mRNA processing
... is pre- dicted to be mediated by the SR-rich re- gion of RBM20 ...with alternative splicing factors, but did not interfere with core splic- ing factor ...additional alternative splicing ...
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