Predictive biomarkers
Predictive biomarkers in precision medicine and drug development against lung cancer
... using predictive biomarkers and patient stratifications in clinical trials to increase the chance of success or to reduce the attrition rate in anticancer drug ...tive biomarkers for patient ...
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Predictive biomarkers for tumor immune checkpoint blockade
... a predictive efficacy biomarker of immunotherapy, and also investigated the possibility of TMB, TILs, GEP, and peripheral blood markers as novel ...of predictive biomarkers of efficacy may only ...
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Predictive biomarkers for dasatinib treatment in melanoma
... of predictive biomarkers for dasatinib may facilitate selection of melanoma patients who are more likely to respond to ...6 biomarkers did not correlate with response, whilst elevated protein ...
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Drug targets and predictive biomarkers in the management of metastatic melanoma
... by the Federal Drug Administration has led to a new era in melanoma treatment, and additional promising drugs and drug combinations are currently being investigated. As the choices of treatment for melanoma have ...
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Extracellular nucleic acids and their potential as diagnostic, prognostic and predictive biomarkers
... or predictive biomarkers for cancer has indicated that, while these NAs are detected in both plasma and serum from both healthy individuals as well as those suffering from a broad range of cancer types, ...
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The need for a network to establish and validate predictive biomarkers in cancer immunotherapy
... reproducible, predictive biomarkers and developing robust companion diagnostics substan- tially benefit from the correlation to genomics and complex tissue analysis ...
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Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma
... Many novel approaches to improve GB therapy rely on targeting specifically altered signal transduction cascades. However, these so called targeted therapies, in- cluding those targeting EGFR, thus far, have failed to ...
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An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer
... Colorectal cancer (CRC) is the third most common cancer in the world. According to recent epidemiological data, in 2014 nearly 50,310 patients died from CRC with a substantial equality distributed in both sex [1]. ...
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The evolving landscape of predictive biomarkers of response to PARP inhibitors
... While lack of PARP-1 confers high resistance to PARPis, it has not been established whether or not the levels of PARP-1 directly correlate with tumor response.. In this issue of the JCI,[r] ...
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Causal Measures for Prognostic and Predictive Biomarkers
... In this article, we defined causal measures that indicate whether a biomarker is prognostic and/or predictive. Our measure for prediction is the causal measure version of the interaction term used in ordinal ...
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Addressing heterogeneity (and homogeneity) in treatment mechanisms in depression and the potential to develop diagnostic and predictive biomarkers
... It has been 10 years since machine learning was fi rst applied to neuroimaging data in psychiatric disorders to identify diagnostic and prognostic markers at the level of the individual. Proof of concept fi ndings in major ...
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Baseline CXCL10 and CXCL13 levels are predictive biomarkers for tumor necrosis factor inhibitor therapy in patients with moderate to severe rheumatoid arthritis: a pilot, prospective study
... In conclusion, our results show that serum levels of CXCL10 and CXCL13 may be valuable predictive bio- markers of response to TNF inhibitor therapy. The decrease of CXCL10 and CXCL13 after treatment in responders ...
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TNFAIP8 variants as potential epidemiological and predictive biomarkers in ovarian cancer
... Wentzensen N, Lissowska J, Garcia-Closas M, Massuger LF, Kiemeney LA, Van Altena AM, Aben KK, Berchuck A, Doherty JA, Iversen E, McGuire V, Moorman PG, Pharoah P, Pike MC, Risch H, Sieh W, Stram DO, Terry KL, Whittemore ...
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Characteristics and predictive biomarkers of drug resistant epilepsy -- study in Georgia
... estimate predictive factors for timely identification of patients at higher risk for developing drug resistant ...independent predictive value for development of intractable epilepsy: frequency of seizure, ...
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On the assessment of the added value of new predictive biomarkers
... new biomarkers are useless), the LR test and the Wald test both yield the nominal type I error rate whereas the DeLong test of AUC yields type I error that is far below the nominal level ...new biomarkers ...
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Plasma specific miRNAs as predictive biomarkers for diagnosis and prognosis of glioma
... We obtained 10 blood samples from patients with a histo- pathologically confirmed diagnosis of GBM and 10 healthy volunteers with a matched distribution of age and sex served as controls. In our studies, nine miRNAs ...
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Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets
... established predictive biomarkers of response to these agents in RCC or other solid tumor types, and in excess of 30% of patients will not derive benefit from ...of predictive and surrogate ...
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CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia
... Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia. Lee DW, Kochenderfer JN, Stetler-[r] ...
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Review Article Immunohistochemistry in diagnostic surgical pathology: contributions of protein life-cycle, use of evidence-based methods and data normalization on interpretation of immunohistochemical stains
... al, image quality, and their effects on the re- sults should be noted [57, 58]. The DAB- stained slides can be analyzed by spectral im- aging [59], color deconvolution [54, 55, 60, 61], Hue-Saturation-Intensity [61], ...
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Ecologically informed microbial biomarkers and accurate classification of mixed and unmixed samples in an extensive cross-study of human body sites
... genus level, we find frequent cases of genera that include biomarker OTUs of the same association type for differ- ent body sites. For example, while most Prevotella markers were positively associated with saliva, one ...
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