Premature Senescence
Oxidative stress and premature senescence in corneal endothelium following penetrating keratoplasty in an animal model
... We assessed premature senescence of endothelia using a normal-risk orthotopic mice corneal transplantation model for three times (totally 60 mice). We collected 8, 11, and 10 corneal grafts for these three ...
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Cell Cycle Arrest by Human Cytomegalovirus 86-kDa IE2 Protein Resembles Premature Senescence
... lular senescence is accompanied by a series of changes that, together, distinguish senescence from quiescence or differen- tiation (8, ...for premature senescence induced by HCMV ...
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Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells
... of premature senescence, we used low doses of H 2 O 2 as a stressor to induce premature senescence in HEI-OC1 auditory ...induce premature senescence in other cell types as well, ...
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Altered myogenesis and premature senescence underlie human TRIM32-related myopathy
... cellular senescence [4] and TRIM32-deficient primary myoblasts from T32KO mice have been demon- strated to undergo premature senescence and impaired myogenesis due to accumulation of PIAS4 ...that ...
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Caveolin 1 expression and stress induced premature senescence in human intervertebral disc degeneration
... cellular senescence within the human IVD and suggested a role for senescence in IVD ...degeneration. Senescence occurs with ageing but can also occur prematurely in response to ...stress-induced ...
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The antioxidative defense system is involved in the premature senescence in transgenic tobacco (Nicotiana tabacum NC89)
... leaf senescence, starting from the basal leaves and advancing toward the apical ...of senescence in tobacco ...Tobacco senescence is largely independent of floral development making it a model plant ...
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MiR-23a-depressed autophagy is a participant in PUVA- and UVB-induced premature senescence
... Autophagy is a cellular catabolic mechanism that is activated in response to stress conditions, including ultraviolet (UV) irradiation, starvation, and misfolded protein accumulation. Abnormalities in autophagy are ...
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Aging with ING: a comparative study of different forms of stress induced premature senescence
... cellular senescence. Cells also show many senescence- associated phenotypes as a consequence of physiological ...of senescence is called stress-induced premature senescence or SIPS, and ...
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Gadd45b deficiency promotes premature senescence and skin aging
... culture-induced senescence similar to Gadd45b, where their loss resulted in premature ...induced senescence and molecular pathways regulated by these other ...in premature senescence is ...
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SIRT1 protects against emphysema via FOXO3 mediated reduction of premature senescence in mice
... replicative senescence) ...replicative senescence is unclear, although telomere length is a determinant of emphysema susceptibility ...and senescence-related genes, such as Wnt/β-catenin, Notch, ...
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High magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK ROS pathway
... cell senescence in the porcine disc organ culture ...cell senescence and ageing-related disc degeneration in vitro and in vivo [22, 56, ...cell senescence in the rat disc organ ...
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Diagnosis of Premature Senescence of Cotton Using SPAD Value
... There have been many studies on the chlorophyll content of cotton leaves assessed with chlorophyll meters [14] [15]. Chlorophyll content increased in cotton leaves when plants were subjected to drip irrigation below the ...
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The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts
... Cellular senescence is believed to function as a tumor suppression mechanism, yet the senescence- associated secretory phenotype can promote cancer development and progression by stimulating the ...
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Original Article Initiation of premature senescence by Bcl-2 in hypoxic condition
... results showed that expression of both p53 and p16 did not changed at each time points observed (Figure 2A). CoCl 2 -induced senes- cence appears to be independent of these pathways and engage others. Bcl-2 was report- ...
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Is senescence-associated β-galactosidase a marker of neuronal senescence?
... to senescence because silencing of the Glb1 gene, which encodes lysosomal β-galactosidase, does not alleviate the symptoms of senescence ...than senescence we witnessed a continued growth of neurons, ...
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Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts
... cellular senescence characteristic of G6PD-deficient fibroblasts would seem to represent a clear case of a senescence mechanism based on accumu- lated oxidative DNA damage rather than one involving ...
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Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... Cellular senescence is a programmed response triggered in normal cells experiencing various types of stimuli, including telomere erosion [1-3], DNA damage [4], induction of oncogenes [5] and oxidative stress ...
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NOX4 downregulation leads to senescence of human vascular smooth muscle cells
... stress-induced premature senescence (SIPS) of vascular smooth muscle cells (VSMCs) induced by doxorubicin or H 2 O 2 , correlates with increased level of DSB and ...replicative senescence were ...
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Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature
... cellular senescence and we propose that it could be due to the activation of ...cellular senescence in vitro, it cannot be excluded that it may act differently in ...cellular senescence and aging ...
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Original Article Guiqi polysaccharide protects the normal human fetal lung fibroblast WI-38 cells from H
... of GQP. In the present study, we investigated the anti-aging activities of GQP in WI-38 cells treated by H 2 O 2 and the related mechanisms. We found the optimal concentration of H 2 O 2 treatment in inducing ...
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