Preparation of brain sections from a subacute sclerosing
Cloning the Antibody Response in Humans with Chronic Inflammatory Disease: Immunopanning of Subacute Sclerosing Panencephalitis (SSPE) Brain Sections with Antibody Phage Libraries Prepared from SSPE Brain Enriches for Antibody Recognizing Measles Virus Antigens In Situ
... cloned from diseased brain, we prepared an antibody phage display library from the brain of a human with subacute sclerosing panencephalitis (SSPE), a chronic encephalitis caused ...
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Iran with Subacute Sclerosing Panencephalitis
... Three cytopathic strains of subacute sclerosing panencephalitis (SSPE) virus were isolated from brain biopsies of three patients.. These strains were isolated and mainta[r] ...
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Subacute sclerosing panencephalitis: the continuing threat
... the brain tissue although both these patients were immunized af- ter a natural measles ...those from 39 patients with other non-infectious neurological ...
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Subacute sclerosing panencephalitis – Current perspectives
... the brain may show decreased gray matter volume, especially within the frontotemporal cortex, amygdala, and cingulate ...range from increased choline-to-creatinine ratio and inositol-to-creatinine ratios ...
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Subacute Sclerosing Panencephalitis of the Brainstem as a Clinical Entity.
... 5. Conclusions SSPE is a rare but serious complication of measles infection. Overall, measles vaccination is effective as first-line prevention against SSPE. Classically, SSPE affects cortical telencephalic structures ...
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Isolation and Characterization of Subacute Sclerosing Panencephalitis Virus Nucleocapsids
... Subacute sclerosing panencephalitis: propagation of measles virus from brain biopsy in tissue culture. Isolation and properties of the helical nucleocapsid of parainfluenza virus SV-5[r] ...
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Electron Microscopic Observations in Subacute Sclerosing Panencephalitis Brain Cell Cultures: Their Correlation with Cytochemical and Immunocytological Findings
... Subacute sclerosing panencephalitis: propagation of measles virus from brain biopsy in tissue culture. Measles-virus antibody and antigen in subacute sclerosing panencephalitis[r] ...
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Subacute sclerosing panencephalitis in an infant: diagnostic role of viral genome analysis.
... Autopsied brain verified the presence of SSPE and of viral inclusions compatible with both MV and PIV ...mutations from “wild-type” MV, of which five were T(U)-C transitions, typical for SSPE ...derived ...
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Correlation of Quantitative Diffusion Tensor Tractography with Clinical Grades of Subacute Sclerosing Panencephalitis
... the brain parenchyma of patients with ...moving from controls to grade ...in brain abscess have shown large variation in FA val- ues, with no significant changes in MD ...vations from previous ...
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Reduced Gray Matter Volume in the Frontotemporal Cortex of Patients with Early Subacute Sclerosing Panencephalitis
... derived from the spa- tial normalization. An automated brain-extraction procedure that in- corporated a segmentation step was used to remove nonbrain ...contribution from nonbrain voxels and to ...
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Analysis of a Subacute Sclerosing Panencephalitis Genotype B3 Virus from the 2009-2010 South African Measles Epidemic Shows That Hyperfusogenic F Proteins Contribute to Measles Virus Infection in the Brain
... A notable clinical difference between MIBE and SSPE is that the former generally affects patients with defective cellular immunity. In MIBE there is little evidence of an antiviral immune response either peripherally or ...
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The F Gene of the Osaka-2 Strain of Measles Virus Derived from a Case of Subacute Sclerosing Panencephalitis Is a Major Determinant of Neurovirulence
... Further investigation is required to address the question of which amino acid substitution(s) is responsible for neuroviru- lence. The mechanism of the restricted production of infectious cell-free virus by the SSPE F- ...
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A Novel Peptide Derived from the Fusion Protein Heptad Repeat Inhibits Replication of Subacute Sclerosing Panencephalitis Virus In Vitro and In Vivo
... M1 and M2EK had almost the same antiviral activity levels against the SSPE Yamagata-1 strain at nanomolar concentrations in vitro, but only M2EK administration increased the Fig 5. Effects of synthesized peptides on the ...
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Assessment of White Matter Damage in Subacute Sclerosing Panencephalitis Using Quantitative Diffusion Tensor MR Imaging
... values from the temporal lobe white ...in brain parenchyma were considered as patients with abnormal findings on ...varied from 2 ⫻ 2 to 6 ⫻ 6 ...
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Early and Late State Subacute Sclerosing Panencephalitis: Chemical Shift Imaging and Single Voxel MR Spectroscopy
... Although SSPE is an invariably fatal disease, stud- ies about the treatment of SSPE demonstrate that the early initiation of the treatment slows the progression and improves the patient’s quality of life (18, 19). For ...
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Screening Random Peptide Libraries with Subacute Sclerosing Panencephalitis Brain-Derived Recombinant Antibodies Identifies Multiple Epitopes in the C-Terminal Region of the Measles Virus Nucleocapsid Protein
... SSPE brain-derived rAbs. Four brain-derived SSPE rAbs directed against the MV N protein were used to pan a phage- displayed random peptide X 12 ...generated from laser capture microdissection ...
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Subacute sclerosing panencephalitis A case report
... The patient was not cooperative with the physical examination. He remained quiet most of the time when asked questions. When tested on calculations he was unable to perform more than sim[r] ...
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Subacute Sclerosing Panencephalitis in an Identical Twin
... A 5 1 ⁄ 2 -year-old African-American girl presented with a 2-week history of cough, chest pain, vomiting, loose stools, abdominal distention, anorexia, and fever. In ad- dition, she had recurrent oral thrush. Her weight ...
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Expression of defective measles virus genes in brain tissues of patients with subacute sclerosing panencephalitis.
... Measles virus matrix protein detected by immune fluorescence with monoclonal antibodies in the brain of patients with subacute sclerosing panencephalitis. An efficient mRNA- dependent tr[r] ...
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Subacute sclerosing panencephalitis: case based review
... CASE FINDINGS A 5-year old male with a past medical history of Measles infection came to the hospital due to episodes of jerky movements of the lower limbs and trunk associated with repetitive falls for the past 4 weeks, ...
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