presomitic mesoderm
Bowline, a novel protein localized to the presomitic mesoderm, interacts with Groucho/TLE in Xenopus
... ABSTRACT Cells in the prospective somite of Xenopus laevis embryos rotate in an orchestrated manner to form a segregated somite. The prospective somite boundaries are prepatterned by gene expressions in the unsegmented ...
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The differentiation and movement of presomitic mesoderm progenitor cells are controlled by Mesogenin 1
... maintained by a positive-feedback loop between Wnt, ntl and Fgf genes. Wnt, Ntl and Fgf (or some combination of these factors) also activate the expression of msgn1, with a particular probability per progenitor cell per ...
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Redefining the role of ectoderm in somitogenesis: a player in the formation of the fibronectin matrix of presomitic mesoderm
... The absence of ectoderm impairs somite formation in cultured presomitic mesoderm (PSM) explants, suggesting that an ectoderm- derived signal is essential for somitogenesis. Here we show in chick that the ...
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Synchronised cycling gene oscillations in presomitic mesoderm cells require cell cell contact
... paraxial mesoderm from the mesenchymal presomitic mesoderm (PSM), which lies either side and juxtaposed to the caudal neural tube, into bilaterally symmetrical epithelial somites, is the earliest ...
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Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm
... In presomitic mesoderm, Notch signalling activity is not restricted to boundary formation, but also appears to be required at earlier (albeit interrelated) stages during the development of presomitic ...
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Mesogenin 1 is a master regulator of paraxial presomitic mesoderm differentiation
... the presomitic mesoderm (PSM) cell fate requires that epithelial NM stem cells undergo ingression in the PS, undertake epithelial-mesenchymal transition (EMT) to become mesoderm, adopt PSM cell ...
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Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm specific enhancer of Mesp2
... The T-box transcription factor Tbx6 controls the expression of Mesp2 , which encodes a basic helix-loop-helix transcription factor that has crucial roles in somitogenesis. In cultured cells, Tbx6 binding to the Mesp2 ...
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receptor tyrosine phosphatase ψ is required for Delta/Notch signalling and cyclic gene expression in the presomitic mesoderm
... the presomitic mesoderm (PSM) in a posterior-to-anterior direction, narrowing as they approach its anterior ...the presomitic to the somitic region of the ...
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Two zebrafish Notch dependent hairy/Enhancer of split related genes, her6 and her4, are required to maintain the coordination of cyclic gene expression in the presomitic mesoderm
... Somitogenesis is coordinated by a ‘clock’ mechanism that ensures the correct spatiotemporal periodicity of somite generation (Maroto and Pourquié, 2001). Although the nature of the clock is still unknown, its existence ...
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Wnt/β catenin regulation of the Sp1 related transcription factor sp5l promotes tail development in zebrafish
... In contrast, markers of presomitic mesoderm such as tbx6, spadetail (spt) (Griffin et al., 1998) and pipetail/wnt5 (ppt) (Krauss et al., 1992; Rauch et al., 1997) fade during early somitogenesis and are ...
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Dynamic expression pattern of distinct genes in the presomitic and somitic mesoderm during Xenopus development
... The cDNA clone 27F11 encodes a protein corresponding to Xenopus aspartate aminotransferase. This protein is highly con- served among vertebrates and the Xenopus protein shows 81% and 80% overall identity to its mouse ...
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Comparative analysis of regulatory elements of the Myf-5 gene
... the presomitic mesoderm have been suggested to inhibit ...the presomitic mesoderm is consistent with its suggested function as a repressor of the myogenic factors (Conlon et al, ...
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RARγ is required for mesodermal gene expression prior to gastrulation in Xenopus
... in mesoderm formation during ...early mesoderm markers and is, therefore, an obligatory factor in mesodermal competence and/ or ...early mesoderm development, suggesting that RA ligand is available ...
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The TAF10 containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo
... during mesoderm development and show that Taf10 loss in the presomitic mesoderm (PSM) does not prevent cyclic gene transcription or PSM segmental patterning, whereas lateral plate differentiation is ...
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Specification of vertebral identity is coupled to Notch signalling and the segmentation clock
... paraxial mesoderm, Hox genes are generally activated in the posterior presomitic mesoderm and remain expressed in somites and their derivatives with distinct To further analyse requirements for Notch ...
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BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites
... plate mesoderm To further explore how mutant somites were patterned, the expression for several markers for PXM development was ...and presomitic mesoderm) was expressed as a column on each side of ...
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Embryonic temperature and the relative timing of muscle specific genes during development in herring (Clupea harengus L )
... comparing herring and the few fish species studied to date, the bHLH regions of MyoD and myogenin were highly conserved, with percentage identities comparable to those reported between carp and other vertebrates ...
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Origin and evolution of endoderm and mesoderm
... and mesoderm formation, its evolutionary origin remains an open ...of mesoderm formation is ...of mesoderm formation ...the mesoderm, differentiate on one side of the mesenteries, which ...
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A Failure of Induction in Normal Development
... We are left with the alternatives that the side-plate mesoderm is able to suppress the competence of the lateral ectoderm only while it is still in its place in the whole mesoderm field,[r] ...
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FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development
... The mesoderm-inducing activity of FoxD3 is identical to Smad2- activating members of the TGF family, including the Nodal- related genes required for mesoderm formation (Heasman, 2006; Schier and Shen, ...
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