Primary CNS
Imaging Changes and Cognitive Outcome in Primary CNS Lymphoma after Enhanced Chemotherapy Delivery
... METHODS: Sixteen primary CNS lymphoma patients were followed after CR (no enhancing tumor) by using a methotrexate-based regimen. Neuropsychological (NP) cognitive testing and MR imaging or CT (when MR ...
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An unusual and challenging case of HIV-associated primary CNS Lymphoma with Hodgkin-like morphology and HIV encephalitis
... Primary CNS lymphoma (PCNSL) is fairly common in HIV-infected patients, affecting as many as 10 % of Acquired Immunodeficiency Syndrome (AIDS) patients in some autopsy studies ...
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MR of primary CNS lymphoma in immunologically normal patients
... The computed tomography CT findings of primary · CNS lymphoma have been described previously as an isodense to hyperdense lesion before iodinated contrast administration and shows postco[r] ...
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Primary CNS lymphoproliferative disease, mycophenolate and calcineurin inhibitor usage
... Immunosuppression for solid organ transplantation increases lymphoproliferative disease risk. While central nervous system (CNS) involvement is more rare, we noticed an increase in primary CNS (PCNS) ...
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MR imaging features of intracranial primary CNS lymphoma in immune competent patients
... Early diagnosis of PCNSL is especially important given that the treatment of PCNSL differs substantially from other CNS tumors. A visible tumor on imaging is essen- tial to raise the suspicion of CNS ...
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Radiographic Findings in 32 Cases of Primary CNS Lymphoma
... Computed tomographic CT or angiographic or both findings were analyzed in 32 cases of pathologically proved primary non-Hodgkin lymphoma of the central nervous system.. CT scans were ava[r] ...
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MR Imaging and Angiography of Primary CNS Vasculitis of Childhood
... The finding that unilateral abnormalities were more common than bilateral involvement is in contrast to studies of adult PACNS where most patients had bilateral involvement.5,21,26-28 On[r] ...
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Pierson Syndrome: A Novel Cause of Congenital Nephrotic Syndrome
... processes. Primary CNS is caused by genetic alterations of the glomerular microstructure that cause massive proteinuria unresponsive to immu- nosuppressive therapies, whereas secondary CNS often is ...
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Vol 31, No 12 (2018)
... of primary CNS lymphoma should always be considered when a patient presents with a brain lesion that shows imaging and clinical spontaneous remission and ...
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Clinical Reasoning: A 71-year-old man with rapidly progressive dementia
... PCR for T whipplei was negative. Continued review of the biopsy showed occasional scattered larger cells and additional lymphoid markers performed to evaluate them raised the possibility of lymphoma (figure e-3, A–D). ...
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Primary central nervous system angiosarcoma: two case reports
... Chemotherapy for primary CNS angiosarcoma, as for virtually all soft tissue sarcomas, is problematic. Combination chemotherapy has not been shown to be any more effective than single agent therapy in most ...
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Diabetes insipidus and hypopituitarism in HIV: an unexpected cause
... Central diabetes insipidus (DI) is a rare clinical entity characterized by low circulating levels of antidiuretic hormone (ADH) presenting with polyuria and volume depletion. Pituitary surgery is the most common cause of ...
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Clinical Reasoning: A 48-year-old woman with confusion, personality change, and multiple enhancing brain lesions
... and CNS tuberculosis (TB) can occur at any CD4 count, but the risk increases with greater ...cells/μL, CNS toxoplasmosis, primary CNS lymphoma (PCNSL), and fungal infections such as ...
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Safety, efficacy and survival of patients with primary malignant brain tumours (PMBT) in phase I (Ph1) trials: the 12-year Royal Marsden experience.
... In the United States, the annual incidence rate of primary CNS tumours in adults is 27.86 per 100,000, with gliomas accounting for 65% of malignant tumors[2]. With the advent of targeted therapies in this ...
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Case Report Primary anaplastic large cell lymphoma in the dura of the brain: case report and prediction of a favorable prognosis
... but primary dural lymphomas are usually low-grade mucosa-associated lymphoid tissue (MALT) type B-cell lymphomas ...mented primary CNS ALCLs reveals only one piece of evidence of dural origin out of ...
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Primary angiitis of the CNS (PACNS) and Behçet disease
... All patients with a well-founded suspicion of PACNS should undergo leptomeningeal and cerebral biopsy after thorough differential diagnostic examinations; stereotac- tic biopsies are recommended only for mass lesions. ...
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Caspase 3-Dependent Cell Death of Neurons Contributes to the Pathogenesis of West Nile Virus Encephalitis
... infection. Primary cortical neurons were generated from wild-type mice and treated with vehicle control (black bars) or 50 M (gray bars) and 20 M (white bars) of a pancaspase inhibitor (A) or a caspase ...
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CNS inflammation and neurodegeneration
... its primary endpoint, a change in the ALS function rating scale revised score, and its secondary endpoint, which included respi- ratory function and combined assessment of function and surviv- al ...
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Interleukin 18 in the CNS
... In the CNS, Northern blot analysis failed to detect the presence of IL-Ra [64] and IL-Rb [65] soon after their cloning. The first evidence that IL-18R compo- nents are expressed in brain tissue was obtained by ...
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Drug design for CNS diseases: polypharmacological profiling of compounds using cheminformatic, 3D QSAR and virtual screening methodologies
... These enzymes are all potential drug targets for neurological conditions, including depression, Alzheimer’s disease, obsessive disorders, and Parkinson’s disease. Three groups of dual or multi-target compounds ...
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