Primary effusion lymphoma
Primary effusion lymphoma in a human immunodeficiency virus negative patient with unexpected unusual complications: a case report
... Background: Primary effusion lymphoma is a rare, high-grade non-Hodgkin ’ s lymphoma that usually occurs in immunosuppressed or human immunodeficiency virus-positive individuals in advanced ...
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Repurposing Cytarabine for Treating Primary Effusion Lymphoma by Targeting Kaposi’s Sarcoma Associated Herpesvirus Latent and Lytic Replications
... ABSTRACT Oncogenic Kaposi’s sarcoma-associated herpesvirus (KSHV) is etiologi- cally linked to primary effusion lymphoma (PEL), an aggressive and nontreatable ma- lignancy commonly found in AIDS ...
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Human Herpesvirus 8 (HHV-8)-Encoded Cytokines Induce Expression of and Autocrine Signaling by Vascular Endothelial Growth Factor (VEGF) in HHV-8-Infected Primary-Effusion Lymphoma Cell Lines and Mediate VEGF-Independent Antiapoptotic Effects
... Human herpesvirus 8 (HHV-8) is associated with Kaposi’s sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman’s disease. The role of HHV-8 in these diseases is unclear, but candidate ...
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Oxidative Stress Induces Reactivation of Kaposi's Sarcoma-Associated Herpesvirus and Death of Primary Effusion Lymphoma Cells
... and primary effusion lymphoma (PEL) cells are predominantly infected with latent Kaposi’s sarcoma-associated herpesvirus (KSHV), presenting a barrier to the destruction of tumor ...
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Differential Expression of Viral Bcl-2 Encoded by Kaposi's Sarcoma-Associated Herpesvirus and Human Bcl-2 in Primary Effusion Lymphoma Cells and Kaposi's Sarcoma Lesions
... in primary effusion lymphoma cell ...stimulated primary effusion lymphoma cells, whereas in Kaposi’s sarcoma lesions preferential mononuclear cells, and to a lesser extent ...
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Role of Defective Oct-2 and OCA-B Expression in Immunoglobulin Production and Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation in Primary Effusion Lymphoma
... Primary effusion lymphoma (PEL) is a distinct type of B-cell non-Hodgkin lymphoma characterized by the presence of Kaposi’s sarcoma-associated herpesvirus (KSHV/human herpesvirus ...
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HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease.
... In 1994, a previously unrecognized g-herpesvirus was discov- ered by Chang and Moore [1] with use of representational difference analysis to identify DNA fragments of this virus from Kaposi sarcoma (KS) tissue samples. ...
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Distinct Subsets of Primary Effusion Lymphoma Can Be Identified Based on Their Cellular Gene Expression Profile and Viral Association
... Primary effusion lymphoma (PEL) is a rare and distinct subtype of non-Hodgkin’s lymphoma which is preferentially associated with infection by Kaposi’s sarcoma-associated her- pesvirus (KSHV) ...
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Primary effusion lymphoma: current perspectives
... Abstract: Primary effusion lymphoma (PEL) is a rare and aggressive disease, affecting a unique population of patients who are often elderly or ...
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Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma
... Primary effusion lymphoma (PEL) is a rare form of aggressive B cell lymphoma caused by Kaposi’s sarcoma- associated herpesvirus (KSHV). Current chemotherapy approaches result in dismal ...
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Transcription Pattern of Human Herpesvirus 8 Open Reading Frame K3 in Primary Effusion Lymphoma and Kaposi's Sarcoma
... Human herpesvirus 8 (HHV-8) is found in immunoblastic B cells of patients with multicentric Castleman’s disease (MCD) and, predominantly in a latent form, in primary effusion lymphoma (PEL) cells and ...
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A New Primary Effusion Lymphoma-Derived Cell Line Yields a Highly Infectious Kaposi's Sarcoma Herpesvirus-Containing Supernatant
... A primary effusion lymphoma (PEL) cell line, JSC-1, that yields highly infectious Kaposi’s sarcoma her- pesvirus (KSHV) supernatants was established from the ascitic fluid of a human immunodeficiency ...
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Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir
... as primary effusion lymphoma (PEL) (both classic and extracavi- tary form), multicentric Castleman disease and the germinotropic lymphoproliferative ...Hodgkin lymphoma that primarily affects ...
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The Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Has Broad Signaling Effects in Primary Effusion Lymphoma Cells
... Kaposi’s sarcoma-associated herpesvirus (KSHV/human herpesvirus 8 [HHV-8]) is a gamma-2-herpesvirus responsible for Kaposi’s sarcoma as well as primary effusion lymphoma (PEL). KSHV is a lymphotropic ...
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Kaposi’s sarcoma-associated herpesvirus-infected primary effusion lymphoma has a gene expression profile
... lymphomas, primary effusion lymphoma (PEL) (3), and plasmablastic lym- phoma associated with multicentric Castleman’s disease (MCD) (4, ...lymphomatous effusion in the pleural, peritoneal or ...
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Kaposi's Sarcoma-Associated Herpesvirus K-bZIP Protein Is Necessary for Lytic Viral Gene Expression, DNA Replication, and Virion Production in Primary Effusion Lymphoma Cell Lines
... Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is a gammaherpes- virus that closely resembles Epstein-Barr virus (EBV). KSHV infection is associated with the development of all ...
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Role of Human Herpesvirus 8 Interleukin-6-Activated gp130 Signal Transducer in Primary Effusion Lymphoma Cell Growth and Viability
... Human herpesvirus 8 (HHV-8) infection is associated with Kaposi’s sarcoma, primary effusion lymphoma (PEL), and multicen- tric Castleman’s disease. HHV-8-encoded viral interleukin-6 (vIL-6) is ...
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Human Herpesvirus 8 Viral Interleukin-6 Signaling through gp130 Promotes Virus Replication in Primary Effusion Lymphoma and Endothelial Cells
... H uman herpesvirus 8 (HHV-8) is associated with multicentric Castleman’s disease, primary effusion lymphoma (PEL), and Kaposi’s sarcoma (1–3). HHV-8-encoded viral interleukin-6 (vIL-6) promotes cell ...
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Establishing and characterizing a new primary effusion lymphoma cell line harboring Kaposi’s sarcoma–associated herpesvirus
... body-cavity-based lymphoma, is a rare distinct large B-cell neoplasm that accounts for about 4 % of all AIDS-related non-Hodgkin ’ s lymphomas [3, ...a lymphoma- tous effusion in the pleural, ...
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Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion Lymphoma
... the same condition, resistance to MLN0128 only changed 2-fold. The differential effect in PEL may be explained by the cytostatic activity of rapamycin, which gives PEL the chance to develop resistance. On the other hand, ...
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