primary effusion lymphoma (PEL)
Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma
... Primary effusion lymphoma (PEL) is a rare form of aggressive B cell lymphoma caused by Kaposi’s sarcoma- associated herpesvirus ...of PEL- bearing immune-compromised mice, that ...
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Role of Defective Oct-2 and OCA-B Expression in Immunoglobulin Production and Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation in Primary Effusion Lymphoma
... Primary effusion lymphoma (PEL) is a distinct type of B-cell non-Hodgkin lymphoma that presents most frequently in body cavities as lymphomatous ...for PEL as well as for ...
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Primary effusion lymphoma: current perspectives
... Abstract: Primary effusion lymphoma (PEL) is a rare and aggressive disease, affecting a unique population of patients who are often elderly or ...immunocompromised. PEL is associated ...
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Human Herpesvirus 8 (HHV-8)-Encoded Cytokines Induce Expression of and Autocrine Signaling by Vascular Endothelial Growth Factor (VEGF) in HHV-8-Infected Primary-Effusion Lymphoma Cell Lines and Mediate VEGF-Independent Antiapoptotic Effects
... sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman’s ...In PEL, expres- sion of several HHV-8 genes has been ...in PEL cell lines or effusions that have been ...
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Differential Expression of Viral Bcl-2 Encoded by Kaposi's Sarcoma-Associated Herpesvirus and Human Bcl-2 in Primary Effusion Lymphoma Cells and Kaposi's Sarcoma Lesions
... KS, primary effusion lymphoma (PEL), and multicentric Castleman’s dis- ease (4–6, ...stimulated PEL cells and in KS lesions ...in PEL cell lines and KS and compared this pattern ...
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Kaposi’s sarcoma-associated herpesvirus-infected primary effusion lymphoma has a gene expression profile
... lymphomas, primary effusion lymphoma (PEL) (3), and plasmablastic lym- phoma associated with multicentric Castleman’s disease (MCD) (4, ...5). PEL usually presents as a lymphomatous ...
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Repurposing Cytarabine for Treating Primary Effusion Lymphoma by Targeting Kaposi’s Sarcoma Associated Herpesvirus Latent and Lytic Replications
... IMPORTANCE Primary effusion lymphoma is an aggressive malignancy caused by Kaposi’s sarcoma-associated ...of primary effusion lym- phoma is dismal without specific ...of primary ...
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Primary effusion lymphoma in a human immunodeficiency virus negative patient with unexpected unusual complications: a case report
... Conclusions: Primary effusion lymphoma is a very rare entity that represents 4% of non-Hodgkin ’ s lymphoma cases associated with human immunodeficiency virus and ...of primary ...
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HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease.
... Kaposi sarcoma–associated herpesvirus infection is associated with the development of 3 proliferative diseases: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease. These ...
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Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion Lymphoma
... weight. Effusion volumes were collected from the peritoneal cavity and ...any effusion to be collected, the cavity was washed with PBS to obtained PEL cells still present on the ...
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The Kaposi's Sarcoma-Associated Herpesvirus K12 Transcript from a Primary Effusion Lymphoma Contains Complex Repeat Elements, Is Spliced, and Initiates from a Novel Promoter
... the PEL tumor and ...the PEL tumor, suggest that expression of the DR2 and DR1 repeat elements is of primary importance regardless of which initiation codons are used to express ...the PEL ...
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Kaposi's Sarcoma-Associated Herpesvirus K-bZIP Protein Is Necessary for Lytic Viral Gene Expression, DNA Replication, and Virion Production in Primary Effusion Lymphoma Cell Lines
... that K-bZIP is important for virus replication, as this mutant failed to reactivate and produce infectious viruses (13). On the other hand, Izumiya et al. suggested that overexpression of K-bZIP in B cells results in ...
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Human Herpesvirus 8 Viral Interleukin-6 Signaling through gp130 Promotes Virus Replication in Primary Effusion Lymphoma and Endothelial Cells
... different PEL cell-specific thresholds of STAT3 functionality or different dependencies on STAT3 for support of HHV-8 replica- ...infected PEL cells (7, 24) do not account directly for diminished ...
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De Novo Protein Synthesis Is Required for Lytic Cycle Reactivation of Epstein-Barr Virus, but Not Kaposi's Sarcoma-Associated Herpesvirus, in Response to Histone Deacetylase Inhibitors and Protein Kinase C Agonists
... from primary effusion lymphoma (PEL) (10, 43, 48, ...all PEL cell lines contain KSHV; some are dually infected with KSHV and ...three PEL cell ...
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Kaposi's Sarcoma-Associated Herpesvirus Protein LANA2 Disrupts PML Oncogenic Domains and Inhibits PML-Mediated Transcriptional Repression of the Survivin Gene
... KSHV-infected primary effusion lymphoma (PEL) cells, increases the levels of SUMO2-ubiquitin-modified PML and induces the disruption of PODs by a proteasome-mediated ...in PEL cells by ...
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New approaches to the treatment of human herpesvirus 8-associated disease.
... Human herpesvirus 8 (HHV-8, also known as Kaposi sarcoma-associated herpesvirus or KSHV) is the etiologic agent of Kaposi sarcoma (KS) and primary effusion lymphoma (PEL), as well as many ...
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Comparison of Serologic Assays for Detection of Antibodies against Human Herpesvirus 8
... on primary effusion lymphoma (PEL) cells and an ELISA based on bacterially expressed ORF73 antigen, as well as with other lytic antigen-based as- says, including an IFA based on induced ...
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A population-based study of Kaposi Sarcomaassociated herpesvirus seropositivity in Uganda using principal components analysis
... KSHV: Kaposi sarcoma-associated herpesvirus; HHV8: Human herpesvirus 8; PCA: Principal components analysis; PC: Principal component; KS: Kaposi sarcoma; PEL: Primary effusion lymphoma; H[r] ...
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Role of ORF74-Encoded Viral G Protein-Coupled Receptor in Human Herpesvirus 8 Lytic Replication
... infected primary effusion lymphoma (PEL) cells conditionally expressing the chemokine receptor found that induced vGPCR expression led to cell cycle arrest and to reduced viral lytic gene ...
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Characterization of Monoclonal Antibodies Raised against the Latent Nuclear Antigen of Human Herpesvirus 8
... in primary effusion lymphoma (PEL) cells, and precipitated a 220- to 230-kDa protein doublet corresponding to LNA from HHV-8-infected PEL cell ...
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