Primary Glioblastoma
TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma
... including glioblastoma (GBM). In the present study, 128 primary glioblastoma patients were examined for single nucleotide polymorphisms of TERT in blood and in 92 cases for TERT promoter mutations in ...
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MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype
... Chinese primary glioblastoma (pGBM) samples, identifying two distinct subclasses of pGBMs: the temozolomide (TMZ) chemoresis tant subtype (TCR subtype) and the TMZ chemosensitive subtype (TCS ...
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Identification of intrinsic subtype-specific prognostic microRNAs in primary glioblastoma
... However, due to the complex mechanism of develop- ment and progression of GBM and the diversity of gene mutation, prognoses vary in samples of each subtype. The isocitrate dehydrogenase 1 (IDH1) mutation was re- ported ...
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Primary glioblastoma of the cerebellum in a 19 year old woman: a case report
... cerebellar glioblastoma is rarely made before surgery, even though CT scan and especially MRI have increased the accuracy of defining the nature of the lesion ...supratentorial glioblastoma are ...
5
Primary glioblastoma in the pineal region: a case report and review of the literature
... of the enhanced mass. Despite its rapid and infiltrative nature, glioblastomas generally do not invade the sub- arachnoid space, and rarely metastasize through the cere- brospinal fluid pathway [14]. However, a review of ...
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PROX1 is a novel pathway-specific prognostic biomarker for high-grade astrocytomas; results from independent glioblastoma cohorts stratified by age and IDH mutation status
... of primary glioblastoma, we selected 174 IDH1-R132H1 immunonegative tumors from patients aged ≥ 60 years enrolled in the Nordic phase III trial in elderly patients with newly diagnosed glioblastomas, ...
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TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells
... YKL-40 coded by CHI3L1 gene, a member of the mammalian chitinase-like glycoprotein family is a lectin lacking chitinase activity due to amino acid substitutions in the region corresponding to the chitinase active site. ...
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A differentially expressed set of microRNAs in cerebro-spinal fluid (CSF) can diagnose CNS malignancies
... In our study, RNA of 34 cases of CNS neoplasms (Tab.1) and of 14 cases with no known malignancy or degenerative disease (a total of 82 samples) were processed by NanoString. Samples were allocated to one of the following ...
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A mathematical framework to determine the temporal sequence of somatic genetic events in cancer
... human primary glioblastoma (GBM), we applied RESIC to a genomic dataset containing sequence and copy number in- formation regarding these two genes for 91 primary human GBM samples (3) (Table ...
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Controlled release microspheres loaded with BMP7 suppress primary tumors from human glioblastoma
... Glioblastoma tumor initiating cells are believed to be the main drivers behind tumor recurrence, and therefore therapies that specifically manage this population are of great medical interest. In a previous work, ...
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Genetic and clinical characteristics of primary and secondary glioblastoma is associated with differential molecular subtype distribution
... that IDH1 mutation might characterize the Proneural subtype, however this cannot be considered as a definitive marker for sGBM perfectively. From the perspective of molecular subtypes rather than the clinical evaluation, ...
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MGMT promoter methylation in gliomas assessment by pyrosequencing and quantitative methylation specific PCR
... for primary glioblastoma patients receiving standard radiotherapy and at least concomitant TMZ displayed a trend towards better survival in the patient group with methy- lated MGMT promoter than in the ...
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The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment
... human glioblastoma cell lines T98G, DBTRG, and A172 were purchased from the ATCC and LN405 was obtained from the ...DMSZ. Primary glioblastoma cells P0297 and P0306 were established as described ...
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Treatment of glioblastoma with herbal medicines
... in primary high-grade astrocytoma is adminis- tered; with the progression of primary glioblastoma (GBM), there is no clear strategy of treatment, so the de- cision on the choice of therapy has to be ...
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The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines
... on primary cancer cells, but rather on transformed cell ...treated primary glioblastoma, rhabdomyosarcoma, hepatocellular carcinoma and human embryonic carcinoma cells (NCCIT) with μ-molar ...
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Combination therapy to checkmate Glioblastoma: clinical challenges and advances
... About 90% of GBM are in this subtype, most cases are either primary or de novo glioblastoma [21]. Patients in this subtype are mostly 55 years or older [22]. The overall survival with surgery and ...
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Glioblastoma expression of vitronectin and the alpha v beta 3 integrin Adhesion mechanism for transformed glial cells
... cerebral glioblastoma biopsy material for the expression of adhesive proteins that might potentiate adhesion and invasion demonstrated tumor cell-associated vitronectin ...the glioblastoma tumor ...in ...
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Characterization of an Orthotopic Rat Model of Glioblastoma Using Multiparametric Magnetic Resonance Imaging and Bioluminescence Imaging
... The purpose of my thesis was to develop a multimodality imaging framework using both BLI and mpMRI to characterize the natural progression of orthotopic C6 glioblastoma multiforme expressing red-shifted Luciola ...
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Data integration to prioritize drugs using genomics and curated data
... Our primary results indicate that FGFR inhibitors in breast cancer and CDK inhibitors in ovarian cancer as well as pazopanib in both cancers are predicted to have the largest proportion of putatively sensitive ...
13
Comparative expression pattern of Matrix Metalloproteinases in human glioblastoma cell lines and primary cultures
... In vivo MMPs are regulated by the surrounding tissue and by growth-factors or cytokines [35,38,39]. Glioblasto- mas are highly hypoxic and hypoxia upregulates MMP-2 mRNA expression in U87, U251, U373 and LN18 glioblas- ...
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