primary sensory DRG neurons
Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons
... cord, primary sensory neurons, and preganglionic sympathetic nerves in a consecutive series of elderly autopsy ...the DRG through the dorsal root; 3) LBAS propagates retro- gradely from the ...
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CC chemokine ligand 2 upregulates the current density and expression of TRPV1 channels and Nav1.8 sodium channels in dorsal root ganglion neurons
... of DRG nociceptive neurons and hyperalgesia by directly enhancing the function of ...the DRG was prepared by pretreating primary culture of rat DRG neurons with different ...
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Identifying local and descending inputs for primary sensory neurons
... of primary sensory neurons reside in the dorsal root gan- glia ...thoracic DRG (C5 to T2 segment) and the corresponding spinal cords from viral-injected ...in DRG. Unexpectedly, the ...
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Pain control through selective chemo axotomy of centrally projecting TRPV1+ sensory neurons
... the primary afferent axon is a potent mechanism for analgesia following intrathecal RTX administration, and that this central axotomy occurs with preservation of the neuronal per- ikarya and their peripheral ...
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Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons
... from DRG neurons. In organ culture of adult DRG IL-1β en- hanced axon regeneration ...rat sensory neurons from postnatal day 9–10 treatment with IL-1β increased neurite outgrowth via ...
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Plasticity of primary sensory neurons and their central connections: Normal development and the effects of neonatal axotomy
... (Fitzgerald et al 1990). A key factor in considering the underlying mechanisms is that, unlike the adult, the intact, adjacent saphenous afferents are still in an active growing state. GAP-43, a marker for growing axons, ...
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Neuronal FcγRI mediates acute and chronic joint pain
... within DRG on day 2 (data not shown) or 4 fol- lowing AIA in either genotype (Supplemental Figure ...in primary sensory neurons mediates ...
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A simple, step by step dissection protocol for the rapid isolation of mouse dorsal root ganglia
... Rodent DRG neurons have been used to study sensory nerve development, function, and regeneration [9–11], to aid in drug discovery [12], and to elucidate the mecha- nisms underlying peripheral nerve ...
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The role of NGF in the control of chemical phenotype and growth of adult primary sensory neurons
... lumbar DRG neurons of small and medium diameter (Hokfelt et ...nociceptive sensory neurons were activated (Jessell, 1982) and antidromic stimulation of these nociceptive fibers resulted in the ...
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Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons
... (DRG) neurons 12,13 ...all sensory neurons 14 , and compared phenotypes with mice in which ...of sensory neurons ...of sensory and autonomic neurons 15 ...the ...
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Pain related sensory innervation in monoiodoacetate induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain
... cord neurons results in increased sensitiv- ity of the spinal cord neurons to input from the joint, rendering the spinal cord neurons hyperexcitable ...
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A simple decision to move in response to touch reveals basic sensory memory and mechanisms for variable response times
... to sensory stimulation, most animals, from crayfish to man, take 50–200 ms to make a coordinated motor response like swimming or moving their eyes (Yerkes, 1904; Mcgill & Gibbon, 1965; Fuchs, 1967; Reichert ...
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The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from dorsal root ganglia
... mediators. DRG tissue slices were subjected to im- munofluorescence staining as previously described ...The primary antibodies against various phenotypic mar- kers of cells used were anti-human neurotrophin ...
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The decision to move : response times, neuronal circuits and sensory memory in a simple vertebrate
... by sensory pathway dlc ...unidentified neurons firing irregularly for some time after skin ...unidentified neurons by measuring the timing of the EPSPs they evoked in hdINs following skin stimulation ...
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Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission
... the DRG cannula nor drugs that were injected in the same way (GABA, bicuculline, NO711) were detected in the spinal ...any DRG-injected drugs or optogenetic stimulation, suggesting that the application of ...
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In vivo birthdating by BAPTISM reveals that trigeminal sensory neuron diversity depends on early neurogenesis
... differentiating neurons of vertebrates shortly after their birth (Marusich et ...trigeminal sensory ganglion in zebrafish, we first analyzed the expression of the zebrafish homologue of HuC (Kim et ...
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Long-term neurologic and cardiac correction by intrathecal gene therapy in Pompe disease
... motor neurons of the brainstem and spinal cord, sensory neurons of the brainstem and dorsal root ganglia, and also glial cells, are the most severely affected [39, ...and sensory neuron ...
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Herpes Simplex Virus type 1 lytic viral gene expression during the establishment and maintenance of latency
... to neurons, and influences the size of the latent HSV-1 reservoir (Ellison et ...infected neurons is likely due to replication during the acute infection (Slobedman et ...all, neurons (Simmons et ...
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Neurotrophin switching in developing sensory neurons
... jugulai* neurons are responsive to BDNF, NT3 and NGF in early stages of ...these neurons lose their responsiveness to BDNF and NT3, becoming responsive only to ...derived neurons to BDNF and NT3 play ...
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Cell Surface Expression of H2 Antigens on Primary Sensory Neurons in Response to Acute but Not Latent Herpes Simplex Virus Infection In Vivo
... Paradoxically, neurons are classically regarded as MHC-I ...of primary sensory neurons recovered from sensory ganglia within 1 to 2 weeks of HSV ...some neurons are found to be ...
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