Processing the amyloid precursor protein (APP)
Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein
... the processing of amyloid precursor protein ...Oxysterol-binding protein 1 (OSBP1) is a member of a family of sterol-binding proteins with roles in lipid metabolism, regulation of ...
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Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein
... of amyloid-beta (Ab) peptide, a metabolite of sequential cleavage of amyloid precursor protein (APP), is a critical step in the pathogenesis of Alzheimer’s disease ...death-associated ...
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Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes
... of amyloid precursor protein (APP) processing, modulates in vivo glucose disposal and insulin sensitivity in ...APP processing, in skeletal muscle modifies glucose uptake and oxidation ...
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Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... Abstract Amyloid- β peptide (A β ) accumulation in the brain is an early, toxic event in the pathogenesis of Alzheimer's disease ...proteolytic processing of a transmembrane protein, β ...
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Studies of amyloid precursor protein trafficking and processing
... understanding of mechanisms that regulate processing and trafficking of APP. We found that: 1) APP mainly distributes as cleaved fragments at synapses under normal conditions. However, a pathway for the transport ...
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Processing of Alzheimer's amyloid precursor protein in cultured cells
... Optimem treatment does not have a significant effect on HSP70 mRNA levels in NT2N cells. This is surprising, considering the marked increase in HSP72 protein levels in these cells after the same treatment. There ...
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Regulation of amyloid precursor protein processing by serotonin signaling
... In conclusion, our studies show the complexity of a-secretase regulation upon 5-HT 4d receptor stimulation. Taking into consideration that receptor modulation of signaling pathways depends on the cellular context and ...
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Intracellular Trafficking Governs the Processing of the Amyloid Precursor Protein and the Secretion of Beta-Amyloid
... APP processing by altering its trafficking including GGA1 [102,103], X11a, Fe65 [104,105], AP-4 [106], VPS35 [25] and SorLa ...APP processing by intracellular trafficking may be crucial for regulating Aβ ...
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Herpes simplex virus interferes with amyloid precursor protein processing
... viral protein which cross-reacts non-specifically with the antibody, we immunostained blots produced from gels of viral proteins from our HSV1 ...kDa protein in uninfected cells, and also, at a higher ...
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The role of phospholipase D1 in trafficking and processing of amyloid precursor protein
... this protein reduced Aβ generation, likely via redirecting the traffic of APP (Lane et ...APP processing which is tightly linked to its intracellular traffic in ...the processing of APP with notable ...
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Herpes simplex virus interferes with amyloid precursor protein processing
... that processing of APP as well as its synthesis is affected by HSV1, that this occurs within 6 h of infection, and that the level increases with time after infection up to at least 9 ...viral protein or ICP ...
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SNX27 and SORLA interact to reduce amyloidogenic subcellular distribution and processing of amyloid precursor protein
... associated processing compo- nents in favor of ...amyloidogenic processing components such as ␥-secretase have failed to be clinically effective in treating AD, targeting AD- associated trafficking ...
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Determining the mechanism of dichloroacetate regulated processing of the Alzheimer’s disease related amyloid precursor protein
... - 131 - Perhaps the most interesting results in the current chapter came from the lactic acid supplementation experiments. Here, following 24 h incubations, the metabolite effected a very small but significant decrease ...
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The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: I Molecular Biology and Metabolic Processing
... The amyloid precursor protein gene (APP) and its derivative peptides have important functions in the central nervous system. APP and A fulfil criteria as neuractive peptides: presence, release and ...
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LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease
... APP in the TGN is prolonged by either the retention of APP molecules en route through the TGN to the cell sur- face or by the retrograde transport of internalized APP from the endosomes to the TGN. The second possibility ...
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Mitosis-specific phosphorylation of amyloid precursor protein at Threonine 668 leads to its altered processing and association with centrosomes
... and processing occurs in a mitosis-specific manner and rein- forces the idea that inhibition of cell cycle activation at an early stage may prevent the APP modifications asso- ciated with the development of AD ...
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Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing
... endosomal protein sorting and prominent role in regulating APP trafficking, there has been considerable interest in retromer as a potential engine of pathogenesis for AD [19, 20], but retromer does not operate in ...
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Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing
... endosomal protein sorting and prominent role in regulating APP trafficking, there has been considerable interest in retromer as a potential engine of pathogenesis for AD [19, 20], but retromer does not operate in ...
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Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
... APP sPLIcING As is the case with APLP2, splicing also leads to generation of APP variants that differ in molecular mass. Alternative splicing of APP RNA gives rise to at least 9 translated isoforms, with variable ...
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The amyloid precursor protein: beyond amyloid
... The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the ...
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