Programmed Cell Death 1 Receptor
CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment
... PD-1: Programmed cell death receptor-1; PD-L1: Programmed cell death ligand-1; NSCLC: Non- small-cell lung cancer; ADC: Adenocarcinoma; SCC: ...
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Immunotherapies: The Blockade of Inhibitory Signals
... PD-1: programmed death-1; PD-L1: pro- grammed death-ligand1; BTLA: B and T cell attenua- tor; TCR: T cell receptor; CD: cluster of differentiation; APCs: antigen ...
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Upregulation of programmed death 1 on T cells and programmed death ligand 1 on monocytes in septic shock patients
... Sepsis produces marked alterations in the expression of membrane-associated co-stimulatory/inhibitory molecules. Expression of these accessory molecules appears to contri- bute to the morbidity/mortality seen not only in ...
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Near complete response after single dose of nivolumab in patient with advanced heavily pre-treated KRAS mutant pulmonary adenocarcinoma
... Programmed death 1 (PD-1) receptor is expressed by activated T-cells and engaged by ligands PD-L1 and ...renal cell carcinoma and NSCLC with ongoing regulatory phase III trials ...
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A Novel Role for Programmed Cell Death Receptor Ligand-1 in Sepsis-Induced Intestinal Dysfunction
... protein programmed death-1 (PD-1 or CD279) and its ligand PD-L1 (B7-H1 or CD274) have been reported to be important in the regulation of immune function in animals and patients with ...
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Programmed cell death-1 blockade in recurrent disseminated Ewing sarcoma
... the programmed cell death-1 (PD-1) receptor interaction via its ligands PD-L1 or PD-L2 has shown efficacy in patients with advanced melanoma, non-small cell lung cancer, ...
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Immunotherapy for Merkel cell carcinoma: a turning point in patient care
... T cell activation and proliferation which may become dys- regulated or co-opted and allow the tumor to escape im- mune surveillance ...T cell responses ...get programmed cell death ...
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CXCR2–CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma
... CXC receptor 2; CXCL1: CXC ligand 1; RFS: Recurrence-free survival; OS: Overall survival; PD-L1: Programmed cell death 1 ligand 1; Treg: Regulatory T; MMP9: Matrix ...
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PD 1 tempers Tregs in chronic HCV infection
... T cell responses are critical for controlling infections with viruses such as HIV, HBV, and ...T cell activation can lead to excessive host tissue damage. T cell expression of the inhibitory ...
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Programmed cell death in the developing limb
... that programmed cell death in the limb bud shares many control mechanisms with those regulating proliferation and ...Ib receptor (Yi et al., 2000). However, the receptor implicated in ...
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The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC
... anti-programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) monoclonal antibody has a good effect in the treatment of non-small cell lung cancer (NSCLC), but ...
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The effect of chemotherapy on programmed cell death 1/ programmed cell death 1 ligand axis: some chemotherapeutical drugs may finally work through immune response
... T cell anti-tumor response (Figure ...(Table 1). PD-1 and PD-L1 antibodies have shown considerable clinical efficacy and durability across a range of malignancy subtypes, including melanoma and lung ...
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Immunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1) receptor pathway
... processed antigen bound to major histocompatibility com- plex (MHC) molecules to the T-lymphocytes. To activate and prime the T-cell for its effector phase (ie, to respond against the cancer-related antigens), two ...
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Potential immune escape mechanisms underlying the distinct clinical outcome of immune checkpoint blockades in small cell lung cancer
... and programmed cell death protein-1 (PD-1), are the best ...co-inhibitory receptor CTLA-4, which is expressed on T cells, can outcompete CD28 to bind to CD80 and CD86 on APCs ...
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Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor
... T cell activation, tolerance and immunopathology ...T cell activity and evade antitumor immune responses [10, ...T cell functions and thus eliminate cancers ...
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<p>Use of Programmed Death Receptor-1 and/or Programmed Death Ligand 1 Inhibitors for the Treatment of Brain Metastasis of Lung Cancer</p>
... Several studies have shown that PD-1 inhibitor coupled with CTLA-4 inhibitor has a more effective treatment outcome on brain metastasis of NSCLC. Since the dual immune blocking mode was approved by the FDA for ...
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Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1
... The second patient, CRC-010, is a 69 year old woman initially diagnosed with a stage III mucinous right-sided colon adenocarcinoma. PD-L1 expression in her original primary tumor was observed at the interface of tumor ...
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Identification and validation of stromal-tumor microenvironment-based subtypes tightly associated with PD-1/PD-L1 immunotherapy and outcomes in patients with gastric cancer
... Immune-checkpoint inhibitors targeting PD-1 and PD-L1 have shown promising clinical results for GC [36–38]. The recent advances in the relationship between gene expression and TME in gastric cancer patients [39– ...
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Programmed Cell Death in Neurospora crassa Is Controlled by the Allorecognition Determinant rcd-1
... distant taxa (Figure 6) https://figshare.com/articles/ Programmed_Cell_Death_in_Neurospora_crassa_Is_Controlled_ by_the_Allorecognition_Determinant_rcd-1/10298045. For example, rcd-1 homologs from ...
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The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs
... A study by Azuma K et al. [2] found that inhibition of EGFR signaling with erlotinib led to down-regulation of the expression of PD-L1 in EGFR mutant NSCLC cells but not in those with wild-type EGFR, indicating that the ...
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