Programmed death receptor-1
<p>Use of Programmed Death Receptor-1 and/or Programmed Death Ligand 1 Inhibitors for the Treatment of Brain Metastasis of Lung Cancer</p>
... of programmed death receptor-1/programmed death ligand 1 (PD-1/PD-L1) can stimulate surrounding T cells and thus have antitumor effects in the ...PD- 1/PD-L1 ...
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A Novel Role for Programmed Cell Death Receptor Ligand-1 in Sepsis-Induced Intestinal Dysfunction
... and there are no T cells in these cultures providing PD-1. While the PD-1:PD-L1 pathway is well established in adaptive immunity during chronic infections and cancer, its role in acute infections is less ...
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Near complete response after single dose of nivolumab in patient with advanced heavily pre-treated KRAS mutant pulmonary adenocarcinoma
... Programmed death 1 (PD-1) receptor is expressed by activated T-cells and engaged by ligands PD-L1 and ...a 1-year survival rate of 42 % that declines to 18 % at 3 years [11]—much ...
5
Original Article PD-L1 blockade improves immune dysfunction of spleen dendritic cells and T-cells in zymosan-induced multiple organs dysfunction syndromes
... and programmed death ligand 1 (PD-L1) were expressed on T-cell, B-cell, DC and ...one receptor of co-inhibitor, programmed death 1 (PD-1) was mainly expressed on ...
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CXCR2–CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma
... CXC receptor 2; CXCL1: CXC ligand 1; RFS: Recurrence-free survival; OS: Overall survival; PD-L1: Programmed cell death 1 ligand 1; Treg: Regulatory T; MMP9: Matrix ...
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Upregulation of programmed death 1 on T cells and programmed death ligand 1 on monocytes in septic shock patients
... Sepsis produces marked alterations in the expression of membrane-associated co-stimulatory/inhibitory molecules. Expression of these accessory molecules appears to contri- bute to the morbidity/mortality seen not only in ...
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PD 1 tempers Tregs in chronic HCV infection
... inhibitory receptor programmed death–1 (PD-1) and inhibition of effector T cells (Teffs) by CD4 + Foxp3 + Tregs are among the many described mechanisms for achieving a balanced immune ...
5
Immunotherapy for Merkel cell carcinoma: a turning point in patient care
... get programmed cell death protein 1 (PD-1), another im- mune checkpoint receptor, or one of its associated ligands (PD-L1), and are now FDA-approved for a variety of can- cers ...
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The combination of anti-KIR monoclonal antibodies with anti-PD-1/PD-L1 monoclonal antibodies could be a critical breakthrough in overcoming tumor immune escape in NSCLC
... anti-programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) monoclonal antibody has a good effect in the treatment of non-small cell lung cancer (NSCLC), but not all ...
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Immunotherapies: The Blockade of Inhibitory Signals
... PD-1: programmed death-1; PD-L1: pro- grammed death-ligand1; BTLA: B and T cell attenua- tor; TCR: T cell receptor; CD: cluster of differentiation; APCs: antigen presenting ...
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Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor
... Activation of the immune system for cancer therapy has long been a goal in immunology and oncology [1, 2], and a recent breakthrough in cancer immunotherapy is the immunologic checkpoint blockade [3, 4]. One of ...
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Immunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1) receptor pathway
... Abstract: T-lymphocytes have the potential to recognize cancer antigens as foreign and therefore eliminate them. However, immune checkpoints such as cytotoxic T-lymphocyte- associated antigen (CTLA)-4 and ...
9
Impaired dendritic cell functions in lung cancer: a review of recent advances and future perspectives
... PD‑1: programmed cell death 1; PD‑L1: programmed cell death 1 ligand 1; CTLA4: cytotoxic T‑lymphocyte‑associated antigen‑4; DC: dendritic cell; TME: tumor ...
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CLEC3B as a potential diagnostic and prognostic biomarker in lung cancer and association with the immune microenvironment
... PD-1: Programmed cell death receptor-1; PD-L1: Programmed cell death ligand-1; NSCLC: Non- small-cell lung cancer; ADC: Adenocarcinoma; SCC: Squamous cell carci- ...
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The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs
... > 1 indicated that EGFR-TKI was more effective in PD- L1 positive ...< 1 implied a lower risk of progression or death for patients with positive expression of ...
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Wnt/beta-catenin pathway: modulating anticancer immune response
... WNT-triggered gene transcription [12, 13]. β-catenin translocates into the nucleus where it interacts with TCF/Lef1 and activates TCF/Lef1 transcription com- plex [14–16]. β-catenin also localizes to multiple sub- ...
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Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1
... T-cell receptor sequencing (TCRseq) ...file 1: Table S1Table ...file 1: Table S1Table S6); one of these clones was detected in the original primary tumor ...file 1: Table S1Table S6) per- ...
8
<p>Programmed cell death 1 expression and Epstein-Barr virus infection in chronic lymphocytic leukaemia: a prospective cohort study</p>
... The Shapiro-Wilk test was used to test for normality. Variables were compared using analysis of variance (ANOVA) or the Kruskal-Wallis test, as appropriate. Dunn ’ s test was used for post-hoc comparisons, with the ...
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Novel technologies and emerging biomarkers for personalized cancer immunotherapy
... cell receptor deep sequencing provides the full spectrum of the B and T cell receptor repertoire and can be used to potentially identify immunosequencing biomarkers in both peripheral blood and tumor ...
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Identification and validation of stromal-tumor microenvironment-based subtypes tightly associated with PD-1/PD-L1 immunotherapy and outcomes in patients with gastric cancer
... Gastric cancer (GC) is one of the most common malig- nancies, which has the second-highest tumor-related mortality rate around the world [1, 2]. The overall sur- vival (OS) of GC remains relatively poor because ...
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