proline rich region
A Proline-Rich Region in the Coxsackievirus 3A Protein Is Required for the Protein To Inhibit Endoplasmic Reticulum-to-Golgi Transport
... In contrast to the wild-type phenotype of viruses carrying the single Pro-to-Ala mutations, the P17A/P18A/P19A mutant yielded a quasi-infectious phenotype. Upon multiple RNA transfections, only on one occasion was virus ...
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Characterization of the Proline-Rich Region of Murine Leukemia Virus Envelope Protein
... variable proline-rich region (PRR), located between the N-terminal receptor-binding domain and the more highly conserved C-terminal portion of the surface (SU) ...hypervariable region of the ...
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Characterization of RNA Determinants Recognized by the Arginine- and Proline-Rich Region of Us11, a Herpes Simplex Virus Type 1-Encoded Double-Stranded RNA Binding Protein That Prevents PKR Activation
... segment rich in arginine and ...and proline-rich Us11 RNA binding domain is unrelated to known dsRNA binding elements and thus constitutes a unique recognition motif that interacts with ...
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A Proline-Rich Region in the Zeste Protein Essential for Transvection and white Repression by Zeste1
... proteins have not lost the ability to aggregate through The aggregation properties of the z 1-35 and z 1-42 mutants are similar to wild-type Zeste protein if the sedimenta- the hydrophob[r] ...
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Receptor choice determinants in the envelope glycoproteins of amphotropic, xenotropic, and polytropic murine leukemia viruses.
... Amino acids upstream of the proline-rich region in the SU proteins from the following viruses are shown: amphotropic MLV 4070A 26, polytropic MLV MCF 247 17, xenotropic MLV NZB.IU.6 25, [r] ...
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Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene
... a proline-rich region and a tyrosine that are highly con- served among the b and g subunit ...The proline-rich domains present in the carboxyl ter- mini of ENaC subunits share a SH3 ...
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Alternatively spliced proline rich cassettes link WNK1 to aldosterone action
... a proline-rich region of WNK1 that contain PY motifs, which bind the E3 ubiquitin ligase ...increased proline-rich WNK1 isoform abundance in WT mice but did not alter WNK1 abundance in ...
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Effect of Epitope Position on Neutralization by Anti-Human Immunodeficiency Virus Monoclonal Antibody 2F5
... membrane-proximal region of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein (TM) is critical for envelope (Env)-mediated membrane fusion and contains the target for broadly reactive ...
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Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation
... the proline-rich region of gilZ; lPs, lipopolysaccharide; gilZ-P c , noncovalent complex of Pep-1 with gilZ-P; MTT, 3-(4,5-dimethyl-thiazol-2-yl)-2,5 diphenyl tetrazolium bromide; TnF-a, tumor ...
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Latent TGF β–binding protein 4 modifies muscular dystrophy in mice
... An insertion/deletion polymorphism in Ltbp4 predicts the phenotype in muscular dystrophy. Ltbp4 encodes a TGF- β –binding protein expressed in skeletal and cardiac muscle. (A) The gene structure is shown for Ltbp4. Exons ...
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Cloning and Characterization of Cbl-associated Protein Splicing Isoforms
... Cbl-associated protein (CAP) is an adaptor protein that plays important roles in both signal transduction and cytoskeleton rearrangement. Alternative splicing of the gene SORBS1 results in multiple isoforms of CAP ...
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The Novel Adaptor Protein, Mti1p, and Vrp1p, a Homolog of Wiskott-Aldrich Syndrome Protein-Interacting Protein (WIP), May Antagonistically Regulate Type I Myosins in Saccharomyces cerevisiae
... acidic region of Myo5p (Figure ...the region encompassing the YJL020C Myo3/5p-SH3-AD to a similar extent as Mti1p (665– and YJL021C sequences encodes a single protein, 1157) and Mti1p (799–1157); Mti1p ...
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Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage
... PspC region that binds ...the proline-rich region of PspC, although this was one of the most recognized regions by human antibodies and (ii) human antibodies did not recognize the binding site ...
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C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6
... c-Cbl comprises a conserved phosphotyrosine-binding domain (PTB), a small zinc-binding domain known as the RING finger domain, a proline-rich region, and multiple tyrosine phosphorylation sites. In ...
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Homonuclear 1H NMR and circular dichroism study of the HIV 1 Tat Eli variant
... [13]: region I (residues 1–21) is a proline-rich region and has a conserved Trp 11, region II (residues 22–37) has seven conserved cysteines at positions 22, 25, 27, 30, 31, 34 and 37 ...
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Free Energies, Transition Mechanisms, and Structural Characteristics of Proline-Rich Peptides.
... for proline, with equilibrium structures that are consistent with experimental ...on proline simula- tions, studies 115,120 suggest that changing these is unlikely to strongly impact the free energies and ...
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Conformational Changes in Simian Virus 40 Rearranged Regulatory Regions: Effects of the 21-Base-Pair Promoters and Their Location
... Our laboratory (41, 42) and others (2, 26, 35) have demon- strated that the organization of the SV40 regulatory region influences DNA replication efficiency. To determine relative DNA replication efficiencies, we ...
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Optimizing the Amino Acid Sequences of Peptides and Improving Their Specificity of Binding to SH3 Domains of Target Proteins
... residues in or flanking the proline-rich motif should also be investigated using our method. Third, the current results of peptide-target binding were mainly based on in silico prediction, which often led ...
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Dose Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs
... high proline content and small size ...salivary proline rich proteins (PRPs) ancestral function in the maintenance of oral health at a basal level of mucoproteins secretion, increased by high tannins ...
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The Role of Cathelicidins in the Innate Host Defenses of Mammals
... The cathelicidin storage organelles in neutrophils are secretory granule subsets (Zanetti et al., 1991; Nagaoka et al., 1997; Sorensen et al., 1997b) that can be readily mobilized upon inflammatory or infectious stimuli ...
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