proline-rich region 1
Homonuclear 1H NMR and circular dichroism study of the HIV 1 Tat Eli variant
... [13]: region I (residues 1–21) is a proline-rich region and has a conserved Trp 11, region II (residues 22–37) has seven conserved cysteines at positions 22, 25, 27, 30, 31, 34 ...
11
Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation
... the proline-rich region at the carboxy terminus of GILZ binds the p65 subunit of NFκB and suppresses the immunoinflammatory ...the proline-rich region of GILZ bound activated p65 ...
13
Immunization of Mice with Single PspA Fragments Induces Antibodies Capable of Mediating Complement Deposition on Different Pneumococcal Strains and Cross-Protection
... and proline-rich regions of PspA from clades 1 to 5 (PspA1, PspA2, PspA3, PspA4, and PspA5) by Western blot analysis and reported that anti-PspA4 and anti-PspA5 were able to recognize pneumococci ...
8
The Metastatic Suppressor Nm23-H1 Interacts with EBNA3C at Sequences Located between the Glutamine- and Proline-Rich Domains and Can Cooperate in Activation of Transcription
... binding region. The results of these assays indicate that the region of EBNA3C that inter- acts with Nm23-H1 lies between aa 629 and 792, which encom- passes the proline- and glutamine-rich ...
8
A Proline-Rich N-Terminal Region of the Dengue Virus NS3 Is Crucial for Infectious Particle Production
... WB. For Western blotting (WB) assays, the following antibodies and antisera were used. The immunodetection of E was performed using the specific monoclonal antibody E18 (47). Rabbit polyclonal anti-capsid se- rum was ...
11
Inhibition of PKR Activation by the Proline-Rich RNA Binding Domain of the Herpes Simplex Virus Type 1 Us11 Protein
... Us11 is a basic, 21-kDa RNA binding protein that localizes to the nucleolus, associates with polysomes in infected cells, binds to and regulates the accumulation of at least one viral nonpolyadenylated RNA of unknown ...
7
Effect of Epitope Position on Neutralization by Anti-Human Immunodeficiency Virus Monoclonal Antibody 2F5
... membrane-proximal region of the human immunodeficiency virus type 1 (HIV-1) transmembrane protein (TM) is critical for envelope (Env)-mediated membrane fusion and contains the target for broadly ...
9
A Proline-Rich Region in the Coxsackievirus 3A Protein Is Required for the Protein To Inhibit Endoplasmic Reticulum-to-Golgi Transport
... to 1 ⫻ lysis buffer by the addition of 200 l of 5 ⫻ lysis buffer (250 mM Tris [pH ...in 1 ml of lysis buffer (50 mM Tris [pH 7.4], 150 mM NaCl, 1 mM EDTA, 1% Nonidet P-40, ...
11
Intrabodies as therapeutics for Huntington's disease
... two proline (polyP) repeat domains, modulate the toxicity of mutant Htt ...P-rich region (PRR) of HDx1 are defined by iAbs: MW7 binds the two polyP domains, and Happs 1 and 3, two new iAbs, ...
219
Free Energy and Structural Characteristics of Proline-rich Peptides with Distributed Multiple Guests.
... the proline-rich peptides, these display similar characteristics as the comparable structures with isolated single- and multiple ...A proline which is followed by another proline has almost ...
55
The Novel Adaptor Protein, Mti1p, and Vrp1p, a Homolog of Wiskott-Aldrich Syndrome Protein-Interacting Protein (WIP), May Antagonistically Regulate Type I Myosins in Saccharomyces cerevisiae
... central proline-rich ...and proline-rich region, sug- large cells in both the vrp1 null and end5-1 mutant cell gesting a conserved role for ...
12
Characterization of RNA Determinants Recognized by the Arginine- and Proline-Rich Region of Us11, a Herpes Simplex Virus Type 1-Encoded Double-Stranded RNA Binding Protein That Prevents PKR Activation
... internal region was first incubated with purified GST bound to glutathione-agarose beads to remove molecules that nonspe- cifically interact with this polypeptide and the supporting solid ...a proline- and ...
11
Characterization of the Proline-Rich Region of Murine Leukemia Virus Envelope Protein
... Effects of deletions of the PRR on envelope protein incor- poration into viral particles. Western blot analysis was carried out to examine the levels of the C-terminally truncated enve- lope proteins within viral ...
9
A Proline-Rich Region in the Zeste Protein Essential for Transvection and white Repression by Zeste1
... proteins have not lost the ability to aggregate through The aggregation properties of the z 1-35 and z 1-42 mutants are similar to wild-type Zeste protein if the sedimenta- the hydrophob[r] ...
10
Isolation and characterization of Bradykinin potentiating peptides from Agkistrodon bilineatus venom
... peptides the charged amino acid residues are flanked by either proline, glycine, or tryptophan. The low pI value and the presence of the two charged residues together, might be responsible for the high IC 50 value ...
9
The effect of proline on the network structure of major ampullate silks as inferred from their mechanical and optical properties
... a proline-deficient network versus a proline-rich network on the properties of MA ...either proline-rich (+Pro) or proline-deficient (–Pro) ...the proline-rich ...
11
Heterologous expression of abaecin peptide from Apis mellifera in Pichia pastoris
... Antimicrobial peptides with more than 20 aas proline rich, like abaecin, showed effectiveness against gram- positive bacteria and fungi [38–40]. In another study, the chemically synthetized abaecin peptide, ...
7
PIKE GTPase Signaling and Function
... type 1 (an excitatory postsynaptic marker) ...proximal region of GluR1 in vivo and colocalize with AMPA receptors at excitatory synapses, where it might implicate in AMPA receptors clustering and connecting ...
7
Alternatively spliced proline rich cassettes link WNK1 to aldosterone action
... the proline-rich cassettes were incorporated into L-WNK1, the kinase became a robust NEDD4-2 substrate whose abundance could be upregulated by SGK1, thus placing WNK1 downstream of SGK1 ...containing ...
17
Free Energies, Transition Mechanisms, and Structural Characteristics of Proline-Rich Peptides.
... solvated proline-rich peptide take on its optimal trans conformation only, was deemed an ...the proline residues (16) need to be accounted for, and the notion of an intrinsic PPII propensity would ...
118