Promoter Activity
Regulation of LRRK2 promoter activity and gene expression by Sp1
... MTM, an anti-tumor and antibiotic drug, was dis- covered to bind to GC-rich sequence with high affin- ity [83]. It competitively binds to Sp1 consensus binding site on the SV40 promoter, working as a site- ...
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Reconstructing promoter activity from Lux bioluminescent reporters
... inferred promoter activity suggests both earlier gene expression and more rapid switching off of expression than would be apparent from the light ...cell activity than would be apparent from the ...
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Proliferation associated POU4F2/Brn 3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway
... 3b promoter is increased by autoregulation, whereby Brn-3b can weakly stimulate its own expression by bind- ing to recognition sequences present in its ...the promoter or indirectly by interacting and ...
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Analysis of the transcriptional promoter which regulates the latency-related transcript of bovine herpesvirus 1.
... Our results indicate that the LR promoter has strict orientation preferences in all cell types tested and that in bovine cells, promoter activity is stimulated by infection with BHV-1.. [r] ...
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Liver X receptors alpha gene (NR1H3) promoter polymorphisms are associated with systemic lupus erythematosus in Koreans
... the promoter re- gion of NR1H3 because a shifted band was found in the presence of the −1830 T probe in the EMSA ...allele promoter with a higher affinity compared with that of the 1830 C allele ...higher ...
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The Epstein-Barr Virus Protein BMRF1 Activates Gastrin Transcription
... gastrin promoter without signif- icantly affecting the binding of SP1 or ...gastrin promoter yet activate gastrin promoter activity was initially ...
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Multiple regulatory events influence human cytomegalovirus DNA polymerase (UL54) expression during viral infection.
... UL54 promoter (22, ...UL54 promoter was associated with an 18-bp region of the promoter containing a single copy of a novel inverted repeat, IR1 ...UL54 promoter and significantly reduced the ...
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The histidine-rich calcium binding protein (HRC) promotes tumor metastasis in hepatocellular carcinoma and is upregulated by SATB1
... its promoter activity [25, ...HRC promoter activity, and the EMSA and ChIP assays further confirmed that AP-1 bound to the HRC promoter ...
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A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria
... hTERC promoter activity in the absence of downstream negative regulation using this minimal construct compris- ing ...core promoter activ- ity, confirming a repressive role for this site (figure ...
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Inhibition of MTA1 by ERα contributes to protection hepatocellular carcinoma from tumor proliferation and metastasis
... MTA1 promoter, we performed chromatin immunoprecipitation (ChIP) ...MTA1 promoter via the ERE half-sites, we generated a wildtype MTA1 promoter fragment and a mutant MTA1 promoter with a ...
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Tumour-specific arginine vasopressin promoter activation in small-cell lung cancer
... intrinsic promoter activity in the promoterless construct pVEN, where the ratio of CAT to β Gal expression (n = 3) was zero in both the Lu-165 and NCI-H460 cell ...transcriptional activity of the ...
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Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria
... NF-κB promoter activity and that the effect was evident only when the wild type promoter was used and less pronounced when the promoter was mutated for the NF-κB binding site, it has been ...
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Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1.
... By using various fragments and deletion constructs, this promoter activity 3269 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest To identify promoter regions which contr[r] ...
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EBNA-2 transactivates a lymphoid-specific enhancer in the BamHI C promoter of Epstein-Barr virus.
... Promoter usage for expression of these nuclear proteins may vary or shift in different cell lines and differentiation states 50, but it appears that BamHI-W promoter activity precedes Ba[r] ...
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Transcriptional Regulation of the Human Cytomegalovirus US11 Early Gene
... US11 promoter suggests that two sequence elements are important for activation by the viral immediate-early (IE) ...in promoter activity to 50% of the wild-type ...US11 promoter, mutagenesis ...
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Transcriptional regulation of human JC polyomavirus promoters by cellular proteins YB-1 and Pur alpha in glial cells.
... transcriptional activity of the viral late and early ...early promoter, however, was less than that of the late pro- moter in the transfected cells ...early promoter, but not the late ...
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Transcriptional Regulation of the K1 Gene Product of Kaposi's Sarcoma-Associated Herpesvirus
... K1 promoter activity in latently infected BCBL-1 ...the activity of the K1 promoter in the context of a latent (⫺TPA, ⫺Orf50) and lytic (⫹TPA, ⫹Orf50) KSHV ...K1 promoter region in ...
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cis-Acting Elements within the Candida albicans ERG11 Promoter Mediate the Azole Response through Transcription Factor Upc2p
... ERG11 promoter, the full-length C. albicans ERG11 promoter was fused to the luciferase reporter gene (RLUC) from Renilla reniformis ...for promoter analyses of such genes as CDR1, CDR2, MDR1, OP4, ...
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S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease
... Previous reports had demonstrated a novel role of parkin as a transcriptional repressor of the tumor suppressor gene p53 [20]. In agreement with this observation, in the present study we found that parkin represses p53 ...
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Replication study confirms the association between UBAC2 and Behçet's disease in two independent Chinese sets of patients and controls
... Results: The first-stage study results showed that UBAC2 (rs9513584, Pc = 0.018, OR = 1.4), but not LOC100129342, KIAA1529, CPVL, UBASH3B was associated with the susceptibility to BD in Chinese Han. The fine-mapping ...
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