Promoter methylation
MicroRNA-mediated regulation of target genes in several brain regions is correlated to both microRNA-targeting-specific promoter methylation and differential microRNA expression
... Thus, in order to resolve this apparent discrepancy, I employed multivariate regression models between miRNA-mediated gene regulation, miRNA-targeting-specific promoter methylation, and differential miRNA ...
11
MGMT promoter methylation and 1p/19q co deletion of surgically resected pulmonary carcinoid and large cell neuroendocrine carcinoma
... and methylation-specific polymerase chain reaction (MSP); MGMT promoter methylation was detected in 17 pa- tients ...MGMT methylation than SCLC; however, the difference is not significant ...
6
Promoter methylation regulates cyclooxygenase expression in breast cancer
... of methylation patterns in cell lines 410 and ...COX-2 promoter methylation patterns are also ...COX promoter methylation in line ...reduced methylation of the COX-2 pro- ...
6
Two Steps Methylation Specific PCR for Assessment of APC Promoter Methylation in Gastric Adenocarcinoma
... Promoter methylation could be observed in many types of cancers leading to aberrant transcriptional silencing of tumor suppressor genes ...the promoter, progressively increases with histopathologic ...
8
Methylation profiling of normal individuals reveals mosaic promoter methylation of cancer-associated genes.
... by promoter methylation of genes associated with cancer initiation and progression is a hallmark of tumour ...DNA methylation biomarkers in plasma or other body fluids shows great promise for ...
12
MGMT promoter methylation in gliomas assessment by pyrosequencing and quantitative methylation specific PCR
... conflicting methylation status from the qMSP ...qMSP methylation frequencies are in the lower range of pre- viously reported MSP results ...MGMT promoter methylation in 24% of GBM patients, ...
13
Promoter Methylation in the Genesis of Gastrointestinal Cancer
... the promoter (typically caused by chromosomal ...or promoter methylation, which silences gene ...in promoter methylation and the CpG island methylator phenotype ...
13
Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma
... between promoter methylation and gene silencing has already been extensively demon- strated [31, ...this methylation-induced gene inactivation involve histone modification by histone deacetylases and ...
10
Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception
... Mapping loss-aDMPs to their nearest gene showed that the majority of genes uniquely occurred in a single tissue (2035 genes, 83.6%, Fig. 4d). The relatively few genes found in multiple tissues included CD46 observed in 6 ...
11
Promoter methylation and expression of TIMP3 gene in gastric cancer
... deletions, methylation, chromosomal translocation, and so on ...DNA methylation and gene expression, as well as its corresponding mechanism, is recommended because the results can guide the clinical ...
6
Determination of quantitative and site specific DNA methylation of perforinby pyrosequencing
... of methylation mark- ers, and for investigating the pathophysiology of a number of chronic diseases with suspected immune dys- function ...PRF1 promoter methylation used bisulfite sequencing of ...
9
TFF1 hypermethylation and decreased expression in esophageal squamous cell carcinoma and histologically normal tumor surrounding esophageal cells
... TFF1 promoter methylation, and gene and protein expression in 65 ESCC patients and 88 controls revealed that TFF1 methylation levels were already increased in histologically normal tumor surrounding ...
10
Probabilistic Radiographic Atlas of Glioblastoma Phenotypes
... MGMT promoter methylation and time to progression, ADIFFI statistical analysis identified 2 distinct clusters (a and b in Fig 8D) in a similar location in all glio- blastomas; however, the lateral portion ...
8
PubMedCentral-PMC4890602.pdf
... collected. Promoter methylation of 13 breast cancer-related genes was assessed in archived tumor by methylation-specific PCR and Methyl ...Global methylation in white blood cell DNA was ...
20
Inactivation by sequence-specific methylations of adenovirus promoters in a cell-free transcription system.
... laevis In vitro methylation of promoter region or of main gene of E2A and Si analyses of RNA; only promoter methylation leads to inactivation 11 Transfection of mammalian cells In vitro [r] ...
6
Epigenetic regulation of ID4 in breast cancer: tumor suppressor or oncogene?
... through promoter methylation and that ID4 is methylated as tumors become ...through methylation. Comparing ER+ with ER − tumors, the methylation levels are not the ...
14
Targeted p16Ink4a epimutation causes tumorigenesis and reduces survival in mice
... percentage methylation (blue boxes) was measured based on the signal intensities of C and T (representing meth- ylated and unmethylated cytosines, respectively) in each C of a CpG ...no promoter ...
6
Two independent epigenetic biomarkers predict survival in neuroblastoma
... gene promoter methylation is relevant to NB, we analyzed differences in the methylation levels among different patient ...gene promoter hypermethylation (P = ...overall promoter ...
14
Loss of Glucocorticoid Receptor Expression by DNA Methylation Prevents Glucocorticoid Induced Apoptosis in Human Small Cell Lung Cancer Cells
... DNA methylation could regulate GR expression in hSCLC cells, in a similar manner to that defined in the rat ...by promoter methylation may be specific to ...
11
Altered methylation of glucosylceramide synthase promoter regulates its expression and associates with acquired multidrug resistance in invasive ductal breast cancer
... of methylation at the GCS gene promoter with its expression and MDR in invasive ductal breast ...Immunohistochemistry, methylation-specific PCR (MSP), quantitative real-time (qPCR), westernblot and ...
12