Proneural genes
Evolution of cis regulation of the proneural genes
... precursors Proneural genes are expressed in broad territories in the neuro- epithelium, from which neural precursors are selected in a spaced ...these genes is the ability to restrict their own ...
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Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes
... of proneural genes that encode basic helix-loop- helix (bHLH) transcription factors are expressed in the developing retina, and they control the differentiation of particular cell types in combination with ...
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The homeobox gene Xbh1 cooperates with proneural genes to specify ganglion cell fate within the Xenopus neural retina
... Although Xbh1 has a definite RGC-promoting activity and is regulated by Xath5, it may not mediate all of the abilities of Xath5. For example, Xath5 has a bipolar and photoreceptor- promoting activity in later RPCs ...
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Drosophila Tufted Is a Gain-of-Function Allele of the Proneural Gene amos
... by Amos (Figure 5J, arrow) served as an additional mea- sure of the identity of many ectopic SOPs as precursors for external sensory organs (compare with wild type, inset to J) and contrasted with the activity of the ...
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Lunatic fringe promotes the lateral inhibition of neurogenesis
... of proneural knockdown or misexpression on lfng expression is that they are secondary to the regulation of Delta/Serrate genes that activate ...If proneural genes (or downstream transcription ...
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Polycomb repressive complex PRC2 regulates Xenopus retina development downstream of Wnt/β catenin signaling
... the proneural bHLH factor Ngn1 (Hirabayashi et ...on proneural gene expression in the developing retina, we injected Ezh2 ATG MO, along with β-gal or GFP mRNA as a tracer in one dorsal blastomere of ...
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Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch
... atoh1 genes. First, proneural genes are expressed before sensory fate ...Second, proneural genes are subject to lateral inhibition (and the related process of domain restriction) via ...
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R8 development in the Drosophila eye: a paradigm for neural selection and differentiation
... express proneural genes (light-blue ...expresses proneural genes at a high level and, by lateral inhibition, prevents this enhanced expression in the surrounding cells (dark-blue ...recruit ...
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Establishment of a proneural field in the inner ear
... many genes implicated in the process of neurosensory develop- ment have been identified both in invertebrates and vertebrates (Ghysen and Richelle, 1979, Torres and Giraldez, 1998, Baker and Bronner-Fraser, ...by ...
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Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT
... other proneural genes, we used deficiency chromosomes that delete various regions of the achaete-scute complex (AS-C; ...bHLH proneural genes: ac, sc, l(1)sc and asense ...the proneural ...
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Tufted Is a Gain-of-Function Allele That Promotes Ectopic Expression of the Proneural Gene amos in Drosophila
... of proneural Jan and Jan 1993; Jarman et al. 1993; Goulding et al. genes in groups of cells of the embryonic ectoderm 2000; Huang et ...external Proneural genes confer to cells the capacity to ...
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Charlatan, a Zn finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila
... the proneural gene atonal, which is not a member of the ASC (Jarman et ...the proneural clusters of the macrochaetae and other landmark sensilla, such as the twin sensilla of the anterior wing margin (TSM) ...
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SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation
... A cardinal feature of Notch signaling during CNS development is the capacity to counteract neurogenesis and maintain neural cells in an undifferentiated state. At later stages, Notch signaling may also act instructively, ...
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Neurogenesis in the sea urchin embryo is initiated uniquely in three domains
... a proneural gene, occurs in three domains: anterior neuroectoderm (ANE), ciliary band (CB) and endomesoderm ...(B) Proneural genes are expressed in the same cells and with cells expressing delta ...
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Senseless physically interacts with proneural proteins and functions as a transcriptional co activator
... The Drosophila zinc-finger (Zn-finger) transcription factor Senseless (Sens) and its homologues have been shown to be involved in a variety of cell biological and developmental processes, including cell fate ...
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Proper connectivity of Drosophila motion detector neurons requires Atonal function in progenitor cells
... as proneural genes in many cel- lular contexts ...the proneural gene for photoreceptor cells ...Ato-like proneural gene may have instructed the formation of all neural components in the visual ...
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The Notch targets Esr1 and Esr10 are differentially regulated in Xenopus neural precursors
... and proneural genes (Ma et ...in proneural domains mirroring endogenous ...a proneural context, Notch input to each occurs through architecturally distinct ...
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The Hes gene family: repressors and oscillators that orchestrate embryogenesis
... Notch family members are type I transmembrane receptors for the DSL (Delta, Serrate, Lag-2) family of type I transmembrane ligands (Artavanis-Tsakonas et al., 1999; Selkoe and Kopan, 2003). In mammals, there are four ...
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Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain
... In embryos electroporated with the pCIG control plas- mid (n ≥ 3), no ectopic expression of Nhlh1, Tagln3, Chga and Stmn2 was observed in cells expressing the control plasmid and each gene was normally expressed within ...
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Characterization of the proneural gene regulatory network during mouse telencephalon development
... eight genes putatively regulated by Ngn2 and eight genes regulated by Mash1 were selected based on their levels of downregulation and upregulation in the microarray data, as well as their potential ...
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